Protein Alignment MYO1D and ck

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 1095
• Identity: 361/1095 - (32%)
• Similarity: 539/1095 - (49%)
• Gaps: 191/1095 - (17%)

Human    10 GKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYER 74
            |..|.:.:..:.....:.||.:|:::..|||:.|.::|:||||::|.||..|.|:.||.|::.|.
  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128

Human    75 PPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLL 139
            |||:|||.|.||..|||..:|.||||||||||||||::|.|:||:|||:     .:...::..:|
  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS-----GKHSWIEQQIL 188

Human   140 KSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSF 204
            ::|.:|||||||||.|||||||||||:||:|...|...|..|..|||||||::.|...||::|.|
  Fly   189 EANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVF 253

Human   205 YQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLK-SSINDAAEFRVVADAMKVIGFKPEEIQTVY 268
            |.:|.|.|......|.|..: :.|.|:..|..:. ...:|||||..:..||||:.|..:||..:.
  Fly   254 YCILAGLSADEKSRLDLGMA-ADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEII 317

Human   269 KILAAILHLGNLKF---VVDG-DTPLIENGKVVSIIAELLSTKTDMVEKALLYRTV-ATGRDIID 328
            |:|||:||.||:|:   |||. |...|.....|..:|.||......:..||..||: |.|..::.
  Fly   318 KLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVS 382

Human   329 KQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNN 393
            ....:|.... ||||.|.||.|:|..||.:||..| .|...|:    ...||||||:|||.||.|
  Fly   383 TLSRDQSVDV-RDAFVKGIYGRMFVHIVRKINTAI-FKPRGTS----RNAIGVLDIFGFENFDQN 441

Human   394 SFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDD 458
            |||||||||.||.|||.|:|.:.|.|||||..|.|.|:||::.:||..:||:..:...|:|::|:
  Fly   442 SFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDE 506

Human   459 ACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKN 523
            .. ...|.||:..|..|:...|.|.::...|   ||    .:..|.:.|:||.|.|...||:|||
  Fly   507 EA-RFPKGTDQTMLAKLHKTHGSHKNYLKPK---SD----INTSFGLNHFAGVVFYDTRGFLDKN 563

Human   524 KDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVR 588
            :||...|...|:..|:|..|:.::.:......|..||..|.:|.|:.|:.||:..|:|.:|:::|
  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIR 628

Human   589 CIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLP 653
            |||||:.|.|.:||...|..|:.|.|::|.:|:||||:..|..:.:|:.||:.:.....|.|  .
  Fly   629 CIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAH--R 691

Human   654 SDKEAVKKLIERCGF---QDDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTLAR 715
            :|.:|....|  |..   :.|...|.||:|::....|| ||:.|.::|.|.:|.||:..||.:.|
  Fly   692 TDCQAATSRI--CAVVLGKSDYQLGHTKVFLKDAHDLF-LEQERDRVLTRKILILQRSIRGWVYR 753

Human   716 MRYKRTK-AALTIIRYY------RRYK------------VKSYI----------HEVARRFH--G 749
            .|:.|.: ||:|:.|::      :||:            ::|.:          |.|..:.|  |
  Fly   754 RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARG 818

Human   750 VKTMRDYGKHVKWPSPPKV----------------------------LRRFEEALQTIFNRW--R 784
            ....|:|| |..| :..|:                            ||:.||  |.:.:|.  .
  Fly   819 YLVRREYG-HKMW-AVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEE--QELLHRGNKH 879

Human   785 ASQLIKSIPASDLPQVRAKVAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSG-------TFV 842
            |.::.:......|.::..:....::...:|.::.:...   |..|.|.:.|...|       .|:
  Fly   880 AREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNII---NDAARKQEEPVDDGKLVEAMFDFL 941

Human   843 P----------------VANELKRKDKYMNVLFSCHVRKVNRFSKV---------EDRAIFVTDR 882
            |                |.|:|.            |.:.||:...:         ||.:.|...:
  Fly   942 PDSSSDAPTPHGGRETSVFNDLP------------HAQNVNQDDIIAPIHISEDEEDLSEFKFQK 994

Human   883 H---LYKMDPTKQY--KVMK--TIPLYNLTGLSVSNGKDQLVV------------------FHTK 922
            .   .::.:...||  |.:|  .:||:       :.| |||..                  :||.
  Fly   995 FAATYFQGNVNHQYAKKALKHPLLPLH-------TQG-DQLAAQALWITILRFTGDMPEPKYHTM 1051

Human   923 DNKDLIVCLFSKQPT--------HESRIGELVGVLVNHFKSEK----RHLQVNVT 965
            |..|....:.....|        .|.:..:|:|:..:.|..:|    ||..|::|
  Fly  1052 DRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLT 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	278/666 (42%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		10/21 (48%)
		Myosin_TH1	803..996	CDD:461801	41/232 (18%)
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	278/667 (42%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020