Protein Alignment MYO1D and Myo31DF

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Alignment Length: 1016
• Identity: 547/1016 - (53%)
• Similarity: 711/1016 - (69%)
• Gaps: 22/1016 - (2%)

Human     1 MAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQ 65
            ||.|.  |.|..||||:|.|||.:||.|||.||:.|.|||:||||.||:|||:.:||||.:||.:
  Fly     1 MAMQR--EAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRK 63

Human    66 YKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAE 130
            ||||||:|..||||||||:||:.:|:|.:||||:||||||||||||||.||:||||:||...:.|
  Fly    64 YKGRELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNE 128

Human   131 VERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQ 195
            :|||||:|::||.:||.|||||||||||||||||||||.||:|.||:||.|.|||||||||:.||
  Fly   129 IERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQ 193

Human   196 PGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFK 260
            ||||:||||||||:|.::..||...|||....|:|::.|:.  ..:.:.::::...:|.|.:||.
  Fly   194 PGERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSM--DILTEKSDYKGTCNAFKTLGFS 256

Human   261 PEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRD 325
            .:|:||:::.:||:|||||::|....|..:|.|.:.:...|:||......:..||..|.:|.|.:
  Fly   257 TDEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGN 321

Human   326 IIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIF 390
            ::.|.|...:|.||:||.|||||:|||.||::|||..|..:...|... .|:|||||||||||||
  Fly   322 VMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQAR-FNSVIGVLDIYGFEIF 385

Human   391 DNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAI 455
            |:||||||||||||||||||||:|||||||||||||||.|.:|:||||:||.|||||.|||||||
  Fly   386 DSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAI 450

Human   456 LDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFI 520
            :|:||::||||||:..|.|::..|.||.|::||:|..:||.|:...||||.||||||:|::.|||
  Fly   451 MDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFI 515

Human   521 DKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPY 585
            :||||||:||||||::||.:..|..|||||...|.:.|||||||.|||:.||..||..|..|||:
  Fly   516 EKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPF 580

Human   586 YVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNH 650
            |||||||||.||..:||:||..|||.|||||||:|||||||..||.|:|||.||||||::||||.
  Fly   581 YVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNF 645

Human   651 DLPSDKEAVKKLIERCGFQDDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTLAR 715
            ...||::.|:.|||...|..||.||.||||||:|||||.||..|.:|:..||..|||..||.:.|
  Fly   646 RAGSDRDGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVR 710

Human   716 MRYKRTKAALTIIRYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIF 780
            ..:|:.|||:||:|.|:.||::||:.|:|.|....|.||||||.::||.||...|:.|..|..:|
  Fly   711 RNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMF 775

Human   781 NRWRASQLIKSIPASDLPQVRAKVAAVEMLKGQRADLGLQRAWEGNYLASKPDT---PQTSGTFV 842
            :.|||:.::...|.|:.||:|.::.|...|.|:|...|..|.|.|:|||:..:.   ...:|:..
  Fly   776 DFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIK 840

Human   843 PVANELKRKDKYMNVLFSCHVRKVNRFSKVEDRAIFVTDRHLYKMDPTK-QYKVMK-TIPLYNLT 905
            .:.|.....:.:..||||..|:|.|.|:|..:||..|:|..::|:|..| ::|.|| ||.:..||
  Fly   841 NIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELT 905

Human   906 GLSVSNGKDQLVVFHTKDNKDLIVCLFSK-QPTHESRIGELVGVLVNHFKSEKRH------LQVN 963
            .:|||.|:|||:|||:..||||:..|.|: .|..|.||||:||::     .:|.|      |:||
  Fly   906 SISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIV-----CKKYHDLTGTELRVN 965

Human   964 VTNPVQCSLHGKKCTVSVETRLNQPQPDFTKNRSGFILSVP 1004
            ||..:.|.|.||...::||...|...|:|.......|..||
  Fly   966 VTTNISCRLDGKARIITVEAASNVEVPNFRPKEGNIIFEVP 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	398/657 (61%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		14/21 (67%)
		Myosin_TH1	803..996	CDD:461801	76/204 (37%)
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	398/658 (60%)
		Myosin_TH1	801..977	CDD:461801	69/180 (38%)