Protein Alignment MYO1D and ninaC

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Alignment Length: 843
• Identity: 215/843 - (25%)
• Similarity: 389/843 - (46%)
• Gaps: 118/843 - (13%)

Human    13 DFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPH 77
            |...::.......:.:||.|...|..|:|||::::|:|..::...:.::...:|:.:...|..||
  Fly   336 DLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPH 400

Human    78 LFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSN 142
            :|::||.||:.|....:...||:||||.:||:..::.:::::..: ....|....||::. :|:.
  Fly   401 IFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYL-GDGNRGATGRVESS-IKAI 463

Human   143 CVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQL 207
            .:|.   ||.|..|::|:|......:.|...|...|...|.|:|||.||......:.:||.||..
  Fly   464 LMLV---NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYF 525

Human   208 LQGGSEQ-MLRSLHLQKSLSSYNYIHV-----GAQLKSSIND----AAEFRVVADAMKVIGFKPE 262
            ....::| .|:..:| |:..:|.|:.|     .::||...:|    ...:|...:.::.|.|..:
  Fly   526 YDFINQQNQLKEYNL-KADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHK 589

Human   263 EIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDII 327
            :::||.|:|||||::||::|..:|....:||..:||.|||||.........:|....:..|....
  Fly   590 QLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAE 654

Human   328 DKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDN 392
            .:|:|.:||...|||.|..:|.||..:|:.|||..:   ::...:.|....|.:.|::|||.|:.
  Fly   655 RRQYTTEEARDARDAVASTLYSRLVDFIINRINMNM---SFPRAVFGDTNAIIIHDMFGFECFNR 716

Human   393 NSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILD 457
            |..||..||..||::|..:.|.:...|..|.:.|.|...::::::|:..:|.:..:..|:..|:|
  Fly   717 NGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIID 781

Human   458 DA---CMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGF 519
            ||   |.:...:.|.:        ..||:.|..:....         :..:.||.|.::|....|
  Fly   782 DASRSCQDQDLIMDRV--------SEKHSQFVKKHTAT---------EISVAHYTGRIIYDTRAF 829

Human   520 IDKNKD----TLFQDFK-----RLMYNSSNPVLKNMWPEGKLSI-------TEVTKRPLTAATLF 568
            .|.|:|    .:.:.|:     .:|...:|.:.|    .|.|::       .:.::|...|....
  Fly   830 TDINRDFVPPEMIETFRSSLDESIMLMFTNQLTK----AGNLTMPFEAVQHKDESERKSYALNTL 890

Human   569 KNSMIALVDNL---------------------ASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEY 612
            ....|:.|:||                     |:...::||||:.:.:..|:.|..:..:.|::.
  Fly   891 SAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKA 955

Human   613 LGLLENVRVRRAGFAFRQTYEKFLHRYKMIS-EFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGK 676
            ||:|:.|..|:.||:.|..:::||.||:.:: :|..|   :...|:..:.|..|.. .:..|.||
  Fly   956 LGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEP---VEMTKDNCRLLFLRLK-MEGWALGK 1016

Human   677 TKIFIR--TPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMRYKRTKAALTIIRYYRRYKVKSY 739
            ||:|:|  ....|..|.||:.:.:|::    |.:.|..|||.|.|..|.       ::..|....
  Fly  1017 TKVFLRYYNDEFLARLYELQVKKVIKV----QSMMRALLARKRVKGGKV-------FKLGKKGPE 1070

Human   740 IHEVA-----RRFHGVKTMRDYGKHVKWPSPPKVLRR-------FEEALQTIFNRWRASQLIK 790
            .|:||     :.|.|   .||     :...||.|..:       ..:.::....:||...:.:
  Fly  1071 HHDVAASKIQKAFRG---FRD-----RVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQ 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	187/708 (26%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		9/42 (21%)
		Myosin_TH1	803..996	CDD:461801
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	187/709 (26%)