Protein Alignment MYO1D and Myo10A

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Alignment Length: 1076
• Identity: 344/1076 - (31%)
• Similarity: 512/1076 - (47%)
• Gaps: 175/1076 - (16%)

Human     2 AEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLL-NIYGRDTIEQ 65
            |.|:....|..|..|:|.:.....:.|||||::||.||||.|.::::|||||:. :.||.:..:|
  Fly   148 ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQ 212

Human    66 YKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAE 130
            |.||.|...|||||||..||:.|:   .....:|||||||:||||::|.:|||:||:. |...:.
  Fly   213 YAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-PGGGSA 273

Human   131 VERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQ 195
            ...:...:|::..:|||||||:|.|||||||||||:::.|. .|..:|..|..|||||||::.|.
  Fly   274 SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQA 337

Human   196 PGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRV----VADAMKV 256
            ||||::|.||:|| ||..:..||.:.......|.|::.||      .|.|..||    :..||:|
  Fly   338 PGERNYHVFYELL-GGLSETERSKYGLLEADKYFYLNQGA------TDCASGRVDWESLQGAMQV 395

Human   257 IGFKPEEIQTVYKILAAILHLGNLKF----VVDGDTPLIENGKVVSI--IAELLSTKTDMVEKAL 315
            :|....|.:.:.::|||:|||||:.|    :..|... :|.|....|  .|.||....|.:.:||
  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEG-VEVGSDAEIKWAAHLLHISADGLHRAL 459

Human   316 LYRTVATGRDIIDKQHTE---QEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNT 377
            ..||....   .::.||.   .:|...|||||||:|..||.|:|:|||.|:: |......|.
  Fly   460 TSRTTEAR---AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ-KGGTHDAHR--- 517

Human   378 VIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIV 442
             |.:|||:|||....|||||.||||.||.||..|.:.|.|.||.||.||.:.|..:.:.:|..::
  Fly   518 -ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVI 581

Human   443 DLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRH 507
            .|:.::..||..:|||. .|..:.||..|||..      |.:.:..:|.|..:|  ..::|.:.|
  Fly   582 HLLAKKPVGICHLLDDE-SNFPRATDLSFLEKC------HYNHALSELYARPRI--GAQEFGVTH 637

Human   508 YAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNM-------------WPEGKLSITEVTK 559
            |||.|.|.|.||:|||:|.|..|...|:.:|..|::..:             .|:|. :...||.
  Fly   638 YAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGS-NGRFVTM 701

Human   560 RPL--TAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVR 622
            :|.  |.|..|.:|:..|:.::....|::|||||||.:|.....|......|:.|||:|:.:::|
  Fly   702 KPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIR 766

Human   623 RAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSD-------KEAVKKLIE---RCGFQ-DDVAYGK 676
            :.|:..|..::.|:.||:         |.|||.       :|..:.|:|   |.|.: .|...|.
  Fly   767 QRGYPVRLRFQHFVERYR---------HLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGA 822

Human   677 TKIFIR--------TPRTLFTLEELRAQ----------MLIRIVLF--------LQKVWRGTLAR 715
            |::|:|        :.||    |.||..          ||:|..|.        ||..|||..|:
  Fly   823 TRVFLREALHRALESGRT----ERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQ 883

Human   716 MRYKR-TKAALTIIRYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTI 779
            .||:| .|.|||..|.:|.       .:..||...:::  |:.:..:.....:..|...||.|.:
  Fly   884 QRYERLRKGALTAQRLWRG-------RQARRRVQQLRS--DHRRRQEAREAAQRAREAREAKQAV 939

Human   780 FNRWRASQLIKSIPASDLPQVRAKVAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPV 844
            ..|.:.|.|  .||| :|..:.:|:.......|.|..:        ..|.:.|..|.::   |.:
  Fly   940 LERSQLSYL--DIPA-ELAFIYSKLQGWSPPHGDRHLV--------KVLGTVPGPPSSA---VQL 990

Human   845 ANELKRKDKYMNVLFSCHVRKVNRFSKVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSV 909
            ..:|.:        ||     ..:||.|....:        ::.|.::   ..|.||........
  Fly   991 PEDLGQ--------FS-----FGKFSSVYCNGL--------RLQPRRE---PITAPLLTRAASRD 1031

Human   910 SNGKDQLVVFHTKDNKDLIVCLFSKQPTHESRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHG 974
            .:.:|.|.||.       ::..:|.....|....:|:...:.|.....|.|:..:...:...:||
  Fly  1032 QDFQDALAVFK-------LILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHG 1089

Human   975 KKCTVSVETRL----------NQPQPDFTKNRSGFI 1000
            ........|||          .||...|:|....|:
  Fly  1090 LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFV 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	262/697 (38%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		8/21 (38%)
		Myosin_TH1	803..996	CDD:461801	36/202 (18%)
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	262/698 (38%)
		PTZ00121	<828..>943	CDD:173412	32/127 (25%)
		MyTH4	1014..1171	CDD:470587	24/122 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022