Protein Alignment MYO1D and Myo95E

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1246
• Identity: 299/1246 - (23%)
• Similarity: 510/1246 - (40%)
• Gaps: 376/1246 - (30%)

Human     8 EFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELY 72
            |.|..|.||::.:|...|:.|:..|:::..|||:||..||::|||..::.:..|.:..|..:.::
  Fly     4 EIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68

Human    73 ERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITN------------- 124
            :.|||::.:.:.||:::|.:|:|.|::::|||||||||..|.|:.::..|.:
  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133

Human   125 ---------------------------------------------------PSQRA--------- 129
                                                               ||||:
  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198

Human   130 ----------------------------------------------------------------- 129
                                                                             
  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263

Human   130 ----------------------------------------------------------------- 129
                                                                             
  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328

Human   130 ----EVERVKNMLLKS------------------------------------------------- 141
                |.||.::.|:.|
  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393

Human   142 NCV------LEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERS 200
            .||      |||.|||.|.:|:||||:||..||..||||||:|.||.:|:|||:|:.....|||:
  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERN 458

Human   201 FHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQ 265
            ||.|||||.|...|:|:||.|.:::..|..:.....::   .|...|.....::.|:|...||..
  Fly   459 FHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAME---EDRMNFHYTKRSLDVLGLSCEESN 520

Human   266 TVYKILAAILHLGNLKFV----VDG-DTPLIENGKVVSIIAELLSTKTDMVEKALL-YRTVATGR 324
            ::::::|.:|.|||..||    :|| :...:.|...|...|:||:.:..::...|. ..:..:.:
  Fly   521 SIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQ 585

Human   325 DIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEI 389
            :.:..:...::|:..|:...:.:|.|||.|:|.:||:.::     :|...||  :.:||.||||.
  Fly   586 EDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLK-----STQREKN--LALLDFYGFEA 643

Human   390 FDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIA 454
            .|:||||||.|||..||:.|.|:..||:.|||.|.|||:.|..||||:|:.|.:|:::...||::
  Fly   644 LDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILS 708

Human   455 ILDDACMNVGKVTDEMFLEALNSKLGKHAHF---SSRKLCASDKILEFDRDFRIRHYAGDVVYSV 516
            ::::..:|   ..|.:.|.......| |.:|   .|..:|           |:|||||..|.||:
  Fly   709 LINEPHLN---SNDALLLRVQQCCAG-HPNFMTTGSNSMC-----------FQIRHYASVVNYSI 758

Human   517 IGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLAS 581
            ..|::||.|.|.:......|.|...::::::|||. ...:|||:|.|.::..:..:..|:..:..
  Fly   759 HRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGN-PRRQVTKKPSTLSSNIRTQLQTLLAIVKH 822

Human   582 KEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFT 646
            :..:||.|||||:.|.|..||....:|||.|:.|:..|.:.|.|..:...:.||.||||:::..|
  Fly   823 RRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLT 887

Human   647 WPNHDLPSDKEAVKKLIERCGFQD-DVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWR 710
            ||:....|..|.:..:|....... :...|...:|:|:|||::.||:.|...:..:.:.:|.::|
  Fly   888 WPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFR 952

Human   711 GTLARMRYKRTKAALTII----------------------------------------------- 728
            ...||.|::|.:.:..||
  Fly   953 MYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAID 1017

Human   729 ---RYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIK 790
               ||||::|::.::..:..|. ...|:....  .:||..|..|......|::|::||:......
  Fly  1018 IIGRYYRQWKIRQFLLTIPLRL-PPNTLSPLS--TEWPVAPAFLADASRHLRSIYHRWKCYIYRN 1079

Human   791 SIPASDLPQVRAKVAAVEMLKGQRADLG--LQRAWEGNYLASKPDTPQTSGTFVPVANELKRK-- 851
            |...:...::|.||.|..:.|.::|..|  :...:.|:|:..:             .|:..:|
  Fly  1080 SFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLR-------------HNQQWKKIC 1131

Human   852 ----DKYMNVLFSCHVRKVNRFS-KVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSN 911
                |:|  |:|:..:.|:.|.| |.....:.::...|..:| .:..::...:|...:..:|:|.
  Fly  1132 AETNDQY--VVFADIINKIARSSGKFVPILLVLSTSSLLLLD-QRTLQIKYRVPASEIYRMSLSP 1193

Human   912 GKDQLVVFHTK 922
            ..|.:.|||.|
  Fly  1194 YLDDIAVFHVK 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	233/929 (25%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		7/21 (33%)
		Myosin_TH1	803..996	CDD:461801	28/129 (22%)
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	42/118 (36%)
		Motor_domain	<403..937	CDD:473979	192/559 (34%)
		Myosin_TH1	1092..1288	CDD:461801	28/129 (22%)