DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO1C and ck

DIOPT Version :9

Sequence 1:	NP_001074248.1	Gene:	MYO1C / 4641	HGNCID:	7597	Length:	1063	Species:	Homo sapiens
Sequence 2:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	333/969 - (34%)
Similarity:	516/969 - (53%)	Gaps:	112/969 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    39 ALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMER 103
            |:.|....||:|.:.|.:. .||..:.||..|::|||||||.|.:||:||||:.|.||:...::.
  Fly    56 AMHASSVQGVEDMISLGDL-HEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKL 119

Human   104 YRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGG 168
            |:.....|:|||:||:.|..|..::..|:||.::|||||||||||:||.:||:.|   ....:..
  Fly   120 YKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLA---AISGKHS 181

Human   169 AVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHG 233
            .:..::|::||:|||||||||:|||||||||||:|:.|...|...|..|..|||||||:|.|||.
  Fly   182 WIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHS 246

Human   234 ERNFHIFYQLLEG--GEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF 296
            |||:|:||.:|.|  .:|::...||:..:   |.||..|........:|.:::..:|.|:.|:.|
  Fly   247 ERNYHVFYCILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308

Human   297 TEDEVEDLLSIVASVLHLGNIHFAANEESN---AQVTTENQLKYLTRLLSVEGSTLREALTHRKI 358
            ::.|:.:::.::|::||.|||.:.|....|   .::.....::.:..||.:....|.:|||.|.:
  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373

Human   359 IAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIY 423
            .|.||.::|.|:.:|:...|||..|.:|.|.|..:|.|||.:     :..|...|...:|:|||:
  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTA-----IFKPRGTSRNAIGVLDIF 433

Human   424 GFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFK 488
            |||.|..||||||||||.||.|||.|::...|.|||||..|.|.|:.:::.:|:...||:..|..
  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQL 498

Human   489 GIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTY 553
            .|::::|||...| :.||.|.|.||..|...|.::|..| :|..|       .|.|.|:||.|.|
  Fly   499 NIMALIDEEARFP-KGTDQTMLAKLHKTHGSHKNYLKPK-SDINT-------SFGLNHFAGVVFY 554

Human   554 SVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRS-EL--SDKKRPETVATQFKMSLLQLVEIL 615
            ...||||||.|....:|...:..|.|..:.|.|.:. |:  ..:||..|::|||:.||..|::.|
  Fly   555 DTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTL 619

Human   616 QSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCP 680
            .|.:|.::||||||:.|:|..||..|...|::|.|::|.:|:||||:..|..:..|::||:.|.|
  Fly   620 SSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP 684

Human   681 ETWP---TWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATK-- 740
            ...|   |........:..:|  ||  ..:|::|.||:|::....||     ||..|..:.|:
  Fly   685 GVPPAHRTDCQAATSRICAVV--LG--KSDYQLGHTKVFLKDAHDLF-----LEQERDRVLTRKI 740

Human   741 --IQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCP 803
              :|.:.||:.:|::|||::.:||.:|.:|:|...|::....:.....::.|||..||.|..|
  Fly   741 LILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFR-- 803

Human   804 ENAFFLDHVR----------TSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWK 858
                   |:|          ..:|  :||:....:    |    ..::..|.:.|.:.::    :
  Fly   804 -------HLRGHIVGLQAHARGYL--VRREYGHKM----W----AVIKIQSHVRRMIAMR----R 847

Human   859 YCRSISPEWKQ-----QLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEP 918
            | |.:..|.||     ||::......:.:|.|  :.:.:.......||  .|:..|.:|    |.
  Fly   848 Y-RKLRLEHKQFAEVLQLRKLEEQELLHRGNK--HAREIAEQHYRDRL--HELERREIQ----EQ 903

Human   919 IQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQR--IDYANLTGISVSSLSDS 975
            ::               ..|::.:..|   |:.||..||.  :|...|.......|.||
  Fly   904 LE---------------NRRRVEVNMN---IINDAARKQEEPVDDGKLVEAMFDFLPDS 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO1C	NP_001074248.1	MYSc	43..731	CDD:214580	272/698 (39%)
		MYSc_Myo1	62..718	CDD:276829	264/666 (40%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	608..630		10/21 (48%)
		IQ	756..776	CDD:197470	7/19 (37%)
		Myosin_TH1	874..1041	CDD:283635	20/104 (19%)
ck	NP_001285949.1	MYSc	64..733	CDD:214580	274/698 (39%)
		MYSc_Myo7	77..721	CDD:276832	265/667 (40%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910