DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO1C and myo1c

DIOPT Version :9

Sequence 1:	NP_001074248.1	Gene:	MYO1C / 4641	HGNCID:	7597	Length:	1063	Species:	Homo sapiens
Sequence 2:	XP_002942189.2	Gene:	myo1c / 100380193	XenbaseID:	XB-GENE-1009886	Length:	1044	Species:	Xenopus tropicalis

Alignment Length:	1034	Identity:	820/1034 - (79%)
Similarity:	935/1034 - (90%)	Gaps:	0/1034 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    30 DGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQ 94
            ||:||||||||||||||||||||||||:|||||||||||:||:|||||||||.||||||||::|:
Frog    11 DGIRVTMESALTARDRVGVQDFVLLENYTSEAAFIENLRKRFKENLIYTYIGSVLVSVNPYKELE 75

Human    95 IYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAE 159
            |||:||||||||||||||.||::|:||..||:|||||:||.::||||||:|||||:|::||:||.
Frog    76 IYSKQHMERYRGVSFYEVSPHIYAIADNSYRSLRTERKDQCILISGESGSGKTEASKKILQYYAV 140

Human   160 TCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEK 224
            ||||.::...|:||||||||||||||||||||||||||||||||||||:||||||||||:|||||
Frog   141 TCPASDQVETVKDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDYKGAPVGGHILNYLLEK 205

Human   225 SRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRK 289
            |||||||||||||||||||||||||:.||||||::|.|:|.||||||||:|||||||:|||:||:
Frog   206 SRVVHQNHGERNFHIFYQLLEGGEEDLLRRLGLDKNAQNYQYLVKGQCARVSSINDKNDWKIVRR 270

Human   290 ALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALT 354
            ||::|:|.||:||:|||:|||||||||:.||:::..:||||||||:|||.|||:|:.:.|||:|.
Frog   271 ALSIINFNEDDVEELLSVVASVLHLGNVQFASDDHGHAQVTTENQIKYLARLLAVDAAALRESLI 335

Human   355 HRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGL 419
            |:|||||||||.||||||||||||||||||:|.|||:|||.|||:|||.|..:..|..:.:|:||
Frog   336 HKKIIAKGEELNSPLNLEQAAYARDALAKAIYGRTFSWLVSKINKSLAYKGSDVLSIGNASVIGL 400

Human   420 LDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVE 484
            |||||||||||||||||||||||||||||||||||||||||||:||||||.||||||||||||||
Frog   401 LDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYESEGIAWESVQYFNNKIICDLVE 465

Human   485 EKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAG 549
            ||||||||||||||||||||||:|||||||||||:||||:||||.||:.||||||.|||||||||
Frog   466 EKFKGIISILDEECLRPGEATDMTFLEKLEDTVKNHPHFVTHKLGDQKLRKSLGRDEFRLLHYAG 530

Human   550 EVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVATQFKMSLLQLVEI 614
            ||.|||.||||||||||||||||.||.|.|||..|||||:||:|||||||||||||.||.:|:||
Frog   531 EVNYSVVGFLDKNNDLLFRNLKEVMCDSGNPIAHQCFDRAELTDKKRPETVATQFKNSLSKLMEI 595

Human   615 LQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLC 679
            |.||||:||||||||||||..||||||||||||||||:||:||||||||||||||.|||||||||
Frog   596 LMSKEPSYVRCIKPNDAKQAARFDEVLIRHQVKYLGLIENVRVRRAGFAYRRKYEIFLQRYKSLC 660

Human   680 PETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAA 744
            |||||.|.||.||||||||:.|||||||||||||||||||||||||||||||.|:||:||.:||.
Frog   661 PETWPNWDGRAQDGVAVLVKSLGYKPEEYKMGRTKIFIRFPKTLFATEDALEERKQSIATFLQAR 725

Human   745 WRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFL 809
            |:||..|:|||.:|.|||.|||||||.:||:||||||||.:.:||.|:|||.|:.||||||.:||
Frog   726 WKGFVQRKKFLHMKHSAIHIQSWWRGNVGRKKAAKRKWAVEVVRRFIKGFVYRNYPRCPENEYFL 790

Human   810 DHVRTSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQK 874
            |::|.|||:||||.:|::|||.|||.|||:|:||||||||:|:.||||.|||.||||.||||:||
Frog   791 DYIRYSFLMNLRRNMPKSVLDKSWPVPPPSLQEASELLREMCMDNMVWMYCRRISPEMKQQLEQK 855

Human   875 AVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQ 939
            .|||||||.|||||||||||||||||||.:||:.::||.:.::.:.||||||||||||||||.||
Frog   856 VVASEIFKDKKDNYPQSVPRLFISTRLGNEEINTKILQNMENQTLTYAVPVVKYDRKGYKPRRRQ 920

Human   940 LLLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLT 1004
            ||||.||..|||:||:|||||||||||||||||||:||||||:..||||||||||||||||||||
Frog   921 LLLTQNAAYIVEEAKLKQRIDYANLTGISVSSLSDNLFVLHVKCEDNKQKGDVVLQSDHVIETLT 985

Human  1005 KTALSANRVNSININQGSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAVVAPRLNSR 1063
            |.|::|.::::|||.||||.|..|.|::|.|||||||||||.|||||||:|||||||||
Frog   986 KIAITAEKIHNINIIQGSIKFTVGHGKEGIIDFTPGSELLIAKAKNGHLSVVAPRLNSR 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO1C	NP_001074248.1	MYSc	43..731	CDD:214580	565/687 (82%)
		MYSc_Myo1	62..718	CDD:276829	534/655 (82%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	608..630		16/21 (76%)
		IQ	756..776	CDD:197470	13/19 (68%)
		Myosin_TH1	874..1041	CDD:283635	124/166 (75%)
myo1c	XP_002942189.2	MYSc_Myo1	43..699	CDD:276829	534/655 (82%)
myo1c	XP_002942189.2	Myosin_TH1	855..1036	CDD:368706	137/180 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1134	1.000	Domainoid score	I467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32046
Inparanoid	1	1.050	1691	1.000	Inparanoid score	I1047
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		oto150256
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2957
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160