Protein Alignment MYO1A and MYO5

DIOPT Version :9

• Sequence 1: NP_001242970.1
• Gene: MYO1A / 4640
• HGNCID: 7595
• Length: 1043
• Species: Homo sapiens
• Sequence 2: NP_013827.1
• Gene: MYO5 / 855136
• SGDID: S000004715
• Length: 1219
• Species: Saccharomyces cerevisiae
• Alignment Length: 1083
• Identity: 348/1083 - (32%)
• Similarity: 538/1083 - (49%)
• Gaps: 199/1083 - (18%)

Human     8 VGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFYE 72
            |||.||.||..:.:|::.:||:.|:.|..||||||:|:|||||::.|.||....:.:|:.....|
Yeast    36 VGVSDLTLLSKISDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLGIYTDAVMNEYKGKNRLE 100

Human    73 LKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCG-KGEQVNSVKEQLL 136
            :.||::|:|...|.:::..:.:||::|:||||:|||||:|.:|.|:||... ..|.:..:|:.:|
Yeast   101 VPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASSTHTESIGKIKDMVL 165

Human   137 QSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHIF 201
            .:||:||:||.|||:|||||||.|||::|:|:.:..|..|.||||||||.|:|.|:|.|||||||
Yeast   166 ATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLEKQRVVSQIKNERNFHIF 230

Human   202 YQLLAGADEQLLKALKLERDTTGYAY------LNHEVSRVDGMDDASSFRAVQSAMAVIGFSEEE 260
            ||...||.:...:...:::... |.|      ::.|.     :||...::....||.|||..:||
Yeast   231 YQFTKGASDAYRQTFGVQKPEQ-YVYTAAAGCISAET-----IDDLQDYQETLKAMRVIGLGQEE 289

Human   261 IRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALCSRTMET- 324
            ..|:..:.:.:|.:|||...:..:.:    :.:||......:..::.::|:.:.::|..|.|||
Yeast   290 QDQIFRMLAAILWIGNVSFIENEEGN----AQVRDTSVTDFVAYLLQIDSQLLIKSLVERIMETN 350

Human   325 --AKEKVV--TALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYGFE 385
              .|...|  ..||::||...||||||.||:.||||||:|:|:|::...|.:|.: |:|||||||
Yeast   351 HGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQAFPGAEKSI-GILDIYGFE 414

Human   386 ILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIE-HNQRGI 449
            |.|.|||||..|||.||||||:||::|||.|||.|:||.|.||.:.||||.::|.||| ....||
Yeast   415 IFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKYFDNKVVCDLIEARRPPGI 479

Human   450 LAMLDEECLRPGV---VSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGK 511
            .|.:::.......   .:|..|..:|| ||:.:.|::.:..:              |.|.||||.
Yeast   480 FAAMNDSVATAHADSNAADQAFAQRLN-LFTTNPHFDLRSNK--------------FVIKHYAGD 529

Human   512 VTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNPKQASLKRPPTAGAQFKSSVAILMK 576
            |||::....|||.|.|.:||::.:....:..|.::||:...:: |.:||||||.:...|...|::
Yeast   530 VTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDTVDRE-SKRRPPTAGDKIIKSANDLVE 593

Human   577 NLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLL 641
            .|....|:|||.|||||.:....:....|..|.:||||.||||:||||:|:||.:..|:||:.||
Yeast   594 TLSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFEKFVERFYLL 658

Human   642 SRSTWPH--------WNGGDREGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQ 698
            |    ||        |.|...:.|:.:|.:.|:...|...|.|.:||::|:|||.||..|.....
Yeast   659 S----PHCSYAGDYTWQGDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTPETLFALEHMRDRYWH 719

Human   699 QLATLIQKIYRGWRCRTHYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKNY 763
            .:|..||:.:|.:                       :|::.....|     ||..:|..|....|
Yeast   720 NMAARIQRAWRRF-----------------------LQRRIDAATK-----IQRTIRERKEGNKY 756

Human   764 RKYFRSEAALTLADFIYKSMVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQELQQLFYQWK 828
            .|         |.|:..|      :||.:....|.::|.       |:..
Yeast   757 EK---------LRDYGTK------VLGGRKERRSMSLLG-------YRAF--------------- 784

Human   829 CKRFRDQLSPKQVEILREKLCASELFKG----KKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGE 889
               ..|.||           |.....||    ::.|..:.|.....|:.:..:.....|:||
Yeast   785 ---MGDYLS-----------CNESKSKGAYIKRQVSIKEKVIFSIHGEALHTKFGRSAQRLK--- 832

Human   890 EGPVLMAEAVKKVNRGNGKTSSRILLLTK------GHVILTDTKKSQAKIVIGLDNVAGVSVTSL 948
                                  :..|||.      |..::.:.........|.:.|:..||:|:|
Yeast   833 ----------------------KTFLLTPTTLYIVGQTLVQNAMTYTQDYKIDVRNIQAVSLTNL 875

Human   949 KDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYR-------------------AVLDATQRQ 994
            :|...::.|:.    ..:.|.|:.:....||:|.:.|                   ..|.:.:.|
Yeast   876 QDDWVAIKLAS----SGQPDPLINTYFKTELITHLKRLNDKIQIKIGSAIEYQKKPGKLHSVKCQ 936

Human   995 LTVTVTEKFSVRFKENSVAVKVVQGPAGGDNSKLRYK--KKGS 1035
            :..: ..|:...:|.::::|:....|    ||::..|  ||.|
Yeast   937 INES-APKYGDIYKSSTISVRRGNPP----NSQVHKKPRKKSS 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1A	NP_001242970.1	MYSc	8..694	CDD:214580	285/709 (40%)
		MYSc_Myo1	22..681	CDD:276829	271/682 (40%)
		Actin-binding. /evidence=ECO:0000255	571..593		9/21 (43%)
		IQ	742..764	CDD:197470	5/21 (24%)
		Myosin_TH1	847..1021	CDD:283635	32/202 (16%)
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	348/1083 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810