DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO1A and Myo1a

DIOPT Version :9

Sequence 1:	NP_001242970.1	Gene:	MYO1A / 4640	HGNCID:	7595	Length:	1043	Species:	Homo sapiens
Sequence 2:	NP_001074688.1	Gene:	Myo1a / 432516	MGIID:	107732	Length:	1043	Species:	Mus musculus

Alignment Length:	1043	Identity:	914/1043 - (87%)
Similarity:	984/1043 - (94%)	Gaps:	0/1043 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPLLEGSVGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKY 65
            ||||||.||||||:|||||.||||:||||||||||||||||||||||:|||:|||||||||||||
Mouse     1 MPLLEGPVGVEDLILLEPLDEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQLPIYGPEFIAKY 65

Human    66 QDYTFYELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQVNS 130
            :||||||||||||||||||||||:|||||||||||||||:|||||||||||||||||||||||||
Mouse    66 RDYTFYELKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNS 130

Human   131 VKEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGE 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
Mouse   131 VKEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGE 195

Human   196 RNFHIFYQLLAGADEQLLKALKLERDTTGYAYLNHEVSRVDGMDDASSFRAVQSAMAVIGFSEEE 260
            ||||||||||||||.|||||||||.||:.|.|||.|||:|:||||||:|||||.||:||||||||
Mouse   196 RNFHIFYQLLAGADAQLLKALKLEEDTSVYGYLNGEVSKVNGMDDASNFRAVQHAMSVIGFSEEE 260

Human   261 IRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALCSRTMETA 325
            ||||||||::|||||||.:.|||||:|||||||.||:|::|||||:||||.|:|||||||||||.
Mouse   261 IRQVLEVTALVLKLGNVKLTDEFQANGIPASGICDGKGIQEIGEMMGLNSTELERALCSRTMETG 325

Human   326 KEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYGFEILEDN 390
            ||||||.|||.||||||||||||||||||||||.|||||||||.|||||||||||||||||||||
Mouse   326 KEKVVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESIKVGTGEKKKVMGVLDIYGFEILEDN 390

Human   391 SFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQRGILAMLDE 455
            ||||||||||||:|||||||:|||||||||||||||||||:||||||||.||||:||||||||||
Mouse   391 SFEQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRGILAMLDE 455

Human   456 ECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKVTYNVTSFI 520
            ||||||||||||||||||||||||.||||||:||||||||.|||||||||.|||||||||||.||
Mouse   456 ECLRPGVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCFRISHYAGKVTYNVTGFI 520

Human   521 DKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNPKQASLKRPPTAGAQFKSSVAILMKNLYSKSPNY 585
            |||||||||||.|.|||||||||:|||||||||:||||||||||.|||:|||:||||||||:|||
Mouse   521 DKNNDLLFRDLSQTMWKAQHPLLKSLFPEGNPKEASLKRPPTAGTQFKNSVAVLMKNLYSKNPNY 585

Human   586 IRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLSRSTWPHWN 650
            |||||||:.||:|:|:|::|..|||||||||||||||||||.||||.|||||||||||||||.||
Mouse   586 IRCIKPNDQQQKGRFTSEMVMVQARYLGLLENVRVRRAGYAFRQGYKPFLERYRLLSRSTWPRWN 650

Human   651 GGDREGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKIYRGWRCRT 715
            |.||||||||||.|::||.|||:|||||||||||||||||||||||||||||||||:||||||||
Mouse   651 GDDREGVEKVLGSLTLSSEELAYGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKVYRGWRCRT 715

Human   716 HYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKNYRKYFRSEAALTLADFIY 780
            |||.|||||||||:|||||.|||.||||::||||||||||||:|||||||||||.||||||:|||
Mouse   716 HYQQMRKSQILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWRARKNYRKYFRSGAALTLANFIY 780

Human   781 KSMVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQELQQLFYQWKCKRFRDQLSPKQVEILR 845
            :||.|||||.||.|||||.|||.|||||||:|.:|||||||:||||||||:||||||||||:.||
Mouse   781 QSMAQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQELQRLFYQWKCKKFRDQLSPKQVQTLR 845

Human   846 EKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGKTS 910
            ||||||||||||||||||||||||.|||||||||||||:|||.||||||:|:.||||||||||||
Mouse   846 EKLCASELFKGKKASYPQSVPIPFRGDYIGLQGNPKLQRLKGREEGPVLVADTVKKVNRGNGKTS 910

Human   911 SRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEH 975
            :||||||||||||||.|||||:|||||::||||||:||:|||||||||||||..||||.||||:|
Mouse   911 ARILLLTKGHVILTDAKKSQAQIVIGLEDVAGVSVSSLQDGLFSLHLSEMSSAVSKGDILLVSDH 975

Human   976 VIELLTKMYRAVLDATQRQLTVTVTEKFSVRFKENSVAVKVVQGPAGGDNSKLRYKKKGSHCLEV 1040
            |:|||||||:||||||||||:|||||||||||||.||||||:|||.||.|.||..|||||:.:||
Mouse   976 VVELLTKMYQAVLDATQRQLSVTVTEKFSVRFKEGSVAVKVIQGPEGGGNRKLICKKKGSNAMEV 1040

Human  1041 TVQ 1043
            ||:
Mouse  1041 TVR 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO1A	NP_001242970.1	MYSc	8..694	CDD:214580	611/685 (89%)
		MYSc_Myo1	22..681	CDD:276829	586/658 (89%)
		Actin-binding. /evidence=ECO:0000255	571..593		19/21 (90%)
		IQ	742..764	CDD:197470	18/21 (86%)
		Myosin_TH1	847..1021	CDD:283635	151/173 (87%)
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	586/658 (89%)
		Actin-binding. /evidence=ECO:0000255	571..593		19/21 (90%)
		IQ	742..764	CDD:197470	18/21 (86%)
		Myosin_TH1	847..1042	CDD:368706	164/194 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83954164
Domainoid	1	1.000	1209	1.000	Domainoid score	I1086
eggNOG	1	0.900	-	-		E2759_KOG0164
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21113
Inparanoid	1	1.050	1839	1.000	Inparanoid score	I1946
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		oto124903
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13107
SonicParanoid	1	1.000	-	-		X12926
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300