DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO1A and didum

DIOPT Version :9

Sequence 1:	NP_001242970.1	Gene:	MYO1A / 4640	HGNCID:	7595	Length:	1043	Species:	Homo sapiens
Sequence 2:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster

Alignment Length:	1222	Identity:	354/1222 - (28%)
Similarity:	584/1222 - (47%)	Gaps:	249/1222 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     8 VGVEDLVLLEPLVEESLLKNLQLRY-ENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFY 71
            ||..||..|..|.|..:|.||::|: |.:.||||.|.:::::|||.::|:|||..|..|:.:...
  Fly    70 VGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMG 134

Human    72 ELKPHIYALANVAYQSLRDRDRDQC---ILITGESGSGKTEASKLVMSYVAAVCGKGEQVNSVKE 133
            :|:|||:|||..||..|   :|:.|   |:::||||:|||.::|..|.|.||| |..|....|:.
  Fly   135 DLEPHIFALAEEAYTKL---ERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV-GGSESETQVER 195

Human   134 QLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPL---GGVITNYLLEKSRLVKQLKGE 195
            ::|.|:|::||||||||.||:|||||||:..:.|..:...:   |..:..|||||||:|.|.:||
  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260

Human   196 RNFHIFYQLLAGADEQLLKALKLERDTTGYAYLN----HEVSRVDGMDDASSFRAVQSAMAVIGF 256
            ||:||||||.|...:  ...|.|:.... :.:||    .|:.||   .||..|.....||.|:||
  Fly   261 RNYHIFYQLCAARSK--YPELVLDHQDK-FQFLNMGGAPEIERV---SDAEQFNETVQAMTVLGF 319

Human   257 SEEEIRQVLEVTSMVLKLGNVLVADEFQASGIPASG-----IRDGRGVREIGEMVGLNSEEVERA 316
            |.::|..::::.:.:|.|||:.|:.:|.........     ..:...::...:::.::::::.|.
  Fly   320 SIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRW 384

Human   317 LCSRTMETAKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDI 381
            |..|.:|:..|.|:...::..||.|||||||:||::||.:||..:|:|:..| .::...:|||||
  Fly   385 LLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNG-SKQCSFIGVLDI 448

Human   382 YGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQ 446
            ||||..|.||||||.|||.||||||.|.:...|.|||||.:|||.||.:|::||.....||| ::
  Fly   449 YGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIE-SR 512

Human   447 RGILAMLDEECLRP-GVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAG 510
            .|:|.:|||||..| |  ||.::..||....:|..|:|..           ..|.:.|.|.|::.
  Fly   513 LGVLDLLDEECRMPKG--SDESWAGKLIGKCNKFPHFEKP-----------RFGTTSFFIKHFSD 564

Human   511 KVTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLF---------------------------- 547
            .|.|:|..|::||.|.:.::|.|.:.::...|.:.:.
  Fly   565 TVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGR 629

Human   548 -PEGNPKQ----ASLKRPPTAGAQFKSSVAILMKNLYSKSPNYIRCIKPNEHQQRGQFSSDLVAT 607
             .:||..:    .|.:...|.|:||:.|:|.|:..|::.:|:|:||||||:.:...::.:..:..
  Fly   630 KQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQ 694

Human   608 QARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLSRSTWPHWNGGDREGVEKVLGELSMSSGELA 672
            |.|..|:||.||:..||:..|..|..|..||:||..          |..::|  .::.:|...:.
  Fly   695 QLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVY----------RSKLDK--NDMKLSCRNIV 747

Human   673 -----------FGKTKIFIRSPKTLFYLEEQRR-----------------------LRLQQLATL 703
                       ||.|:||.|:.:..| ||:.|.                       ||:|::...
  Fly   748 MKWIQDEDKYRFGNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811

Human   704 IQKIYRGWRCRTHYQLMRKSQ--ILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKNY--- 763
            |||..||:..|...|.||:::  :::|.:.||.:.::.|.:::.|:..||.:.||..||..:
  Fly   812 IQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAM 876

Human   764 RKYFRS-------EAALTLADF--------IYKSMVQKFLL-----GLKNNLPSTNVLDKTWPAA 808
            |.::|:       ..||....:        |.::.:::||.     .:|....:.:.::..:...
  Fly   877 RDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGL 941

Human   809 PYKCLSTANQELQQLFYQWKCKRFRDQLSPK--QVEILREKLCASEL-------FKGKKASYPQS 864
            ..|.:| ..|.:.:|      .|....|..|  ::.:|:.||   ||       ||..||:
  Fly   942 ENKIIS-MQQRIDEL------NRDNSNLKHKTSEISVLKMKL---ELKKTLEAEFKNVKAA---- 992

Human   865 VPIPFCGD----------YIGLQGNPKLQKLK---GGEEGPVLMAEAVKKVNRGNGKTSSRILLL 916
                 |.|          .:..:.:.|:|.|:   ..:|..:...:..::.|....:....|:.:
  Fly   993 -----CQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDM 1052

Human   917 TKGHVILTDTKKSQAKIVIGLDN----------------------VAGVSVTSLKDGLFSLHLSE 959
            .|...:  :.:..:.:::..:||                      :....::.|..|.||||..:
  Fly  1053 AKNAEV--NQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARK 1115

Human   960 MSSVGSKGD---------FLLVSEHVIELLTKMY------------RAVLDATQRQLTVTVTE-- 1001
            .|:..|:.:         ..|......:||:|.|            |::|:..:::..|...:
  Fly  1116 ASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYI 1180

Human  1002 KFSVRFK--ENSVAVKVVQGPAGGDNSKLRYK--------KKGSHCLEVTVQ 1043
            |.|.|.|  |:|..|..::    .:|.|||.:        |.|....|:..|
  Fly  1181 KLSSRHKPTEDSFRVSELE----VENEKLRSEYDQLRTSIKHGVEINELNAQ 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO1A	NP_001242970.1	MYSc	8..694	CDD:214580	264/746 (35%)
		MYSc_Myo1	22..681	CDD:276829	253/719 (35%)
		Actin-binding. /evidence=ECO:0000255	571..593		10/21 (48%)
		IQ	742..764	CDD:197470	7/24 (29%)
		Myosin_TH1	847..1021	CDD:283635	42/240 (18%)
didum	NP_724569.1	MYSc	65..778	CDD:214580	264/745 (35%)
		MYSc_Myo5	84..767	CDD:276831	253/719 (35%)
		IQ	900..922	CDD:197470	3/21 (14%)
		GBP_C	<971..1086	CDD:303769	20/128 (16%)
		coiled coil	1049..1068	CDD:293879	2/20 (10%)
		coiled coil	1077..1086	CDD:293879	0/8 (0%)
		JAKMIP_CC3	<1190..1299	CDD:292653	11/43 (26%)
		Myo5_CBD	1424..1792	CDD:271254
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910