DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO1A and myo1

DIOPT Version :9

Sequence 1:	NP_001242970.1	Gene:	MYO1A / 4640	HGNCID:	7595	Length:	1043	Species:	Homo sapiens
Sequence 2:	NP_595402.1	Gene:	myo1 / 2539659	PomBaseID:	SPBC146.13c	Length:	1217	Species:	Schizosaccharomyces pombe

Alignment Length:	1067	Identity:	366/1067 - (34%)
Similarity:	535/1067 - (50%)	Gaps:	188/1067 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     7 SVGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFY 71
            :|||:||.||..:.:|.:.|||:||:.|.|||||||:|:|||||::.|.||..:.:..||.....
pombe    39 TVGVDDLTLLSKITDEEINKNLELRFRNGEIYTYIGHVLISVNPFRDLGIYTMDILKSYQGKNRL 103

Human    72 ELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVC-GKGEQVNSVKEQL 135
            |..||:||:|..||..::....:|||:|:||||:|||||:|.:|.|:..|. ..|.::..|.|.:
pombe   104 ETSPHVYAIAENAYYQMKSYHENQCIIISGESGAGKTEAAKRIMQYITHVSKSVGTEIERVSEII 168

Human   136 LQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHI 200
            |.:||:||:||.|||:|||||||.|||:::.|:..|.|:|..||||||||:|:|.|::.||||||
pombe   169 LATNPLLESFGCAKTLRNNNSSRHGKYLEMIFNSGGVPVGAKITNYLLEKNRIVNQVRNERNFHI 233

Human   201 FYQLLAGADEQLLKALKLERDTTG------YAYLNH-EVSRVDGMDDASSFRAVQSAMAVIGFSE 258
            |||....|.::.       |||.|      |.|.:. :...|||:.|...|:...:||.|||.:|
pombe   234 FYQFTKSAPQKY-------RDTYGIQGPENYVYTSACQCLSVDGISDEKDFQGTMNAMKVIGITE 291

Human   259 EEIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALCSRTME 323
            .|..::..:.|::|.|||:    :||......|.|.|......:|.::|:....:||||..|.|:
pombe   292 PEQDEIFRMLSIILWLGNI----QFQEGQDGGSVISDKSITEFLGYLIGVPVAAIERALTIRIMQ 352

Human   324 T---AKEKVV--TALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYG 383
            |   |:...|  ..||..||...||||:..||:.||||||.|:|:::..........:|:|||||
pombe   353 TQHGARRGSVYEVPLNPTQALAVRDALSMAIYNCLFDWIVERVNKALVTSDNSVSNSIGILDIYG 417

Human   384 FEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQ-R 447
            |||.|:|||||..|||.||||||:|||:|||.|||||.||.|.||.:.||:|.::|.|||..: .
pombe   418 FEIFENNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIAWTPIKYFNNKVVCDLIESKRPP 482

Human   448 GILAMLDEECL---RPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYA 509
            |:.|.:::...   .....:||.|..:||.| |.:.|:|.:..|              |.:.|||
pombe   483 GLFAAMNDAIATAHADSAAADSAFAQRLNFL-SSNPHFEQRQNQ--------------FIVKHYA 532

Human   510 GKVTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLFP---EGNPKQASLKRPPTAGAQFKSSV 571
            |.|||::|...|||.|.|..|:|..:..:.:..::|:||   |.|    |.:||||||.:.|:|.
pombe   533 GDVTYSITGMTDKNKDQLATDILNLIHSSNNEFMKSIFPVAEESN----SRRRPPTAGDRIKTSA 593

Human   572 AILMKNLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLE 636
            ..|::.|....|:|||.||||:.:....:...:|..|.:||||.||:|:||||:|:||.:..|.:
pombe   594 NDLVETLMKCQPSYIRTIKPNQTKSPNDYDQQMVLHQIKYLGLQENIRIRRAGFAYRQAFDTFAQ 658

Human   637 RYRLLSRST----WPHWNGGDREGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRL 697
            |:.:||..|    ...|.|.|:...|::|.:.::.|.|...|.:|:||::|:|||.||:.|....
pombe   659 RFAVLSGKTSYAGEYTWQGDDKSACEQILKDTNIPSSEYQMGTSKVFIKNPETLFALEDMRDKFW 723

Human   698 QQLATLIQKIYRGWRCRTHYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKN 762
            ..:||.||   |.||                                       ::||.
pombe   724 DTMATRIQ---RAWR---------------------------------------SYVRR------ 740

Human   763 YRKYFRSEAALTLADFIYKSMVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQELQQLFYQW 827
                 |||||.                          .:.|.|..      :..|.||:
pombe   741 -----RSEAAA--------------------------CIQKLWNR------NKVNMELE------ 762

Human   828 KCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSV--PIPFCGDYIGL-QGNPKLQKLKG-G 888
               |.|::              .::|.:|||.....|:  ...|.|||:.. :.|..|....| .
pombe   763 ---RVRNE--------------GTKLLQGKKQRRRYSILGSRKFYGDYLSASKPNGTLWNTCGLS 810

Human   889 EEGPVLMA----EAVKKVNRGNGKTSSRILLLTKGHVILTDTKKSQAKIV------IGLDNVAGV 943
            :...|:.:    ..|.|:.| ..|.|.|.|:|||.::.|..||....|:.      ..:.::..|
pombe   811 QNDHVIFSMRCEVLVHKLGR-TSKPSPRQLVLTKKNLYLVITKIVDQKLTQQVEKKFAVSSIDSV 874

Human   944 SVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVTVTEKFSVRFK 1008
            .:|:|:|...::.    :.....||..|......|.:|.:.|     ..|.:.|.|..  ::::.
pombe   875 GLTNLQDDWVAIR----NKSSQNGDMFLRCFFKTEFITTLKR-----INRNIQVIVGP--TIQYC 928

Human  1009 ENSVAVKVVQGPAGGDNSKLRYKKKGS 1035
            .....|:.|:...........|.|.|:
pombe   929 RKPGKVQTVKTAKDETTKDYDYYKSGT 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO1A	NP_001242970.1	MYSc	8..694	CDD:214580	299/709 (42%)
		MYSc_Myo1	22..681	CDD:276829	285/682 (42%)
		Actin-binding. /evidence=ECO:0000255	571..593		9/21 (43%)
		IQ	742..764	CDD:197470	2/21 (10%)
		Myosin_TH1	847..1021	CDD:283635	42/187 (22%)
myo1	NP_595402.1	MYSc	38..720	CDD:214580	299/710 (42%)
		MYSc_Myo1	54..707	CDD:276829	285/682 (42%)
		Myosin_TH1	765..944	CDD:283635	43/204 (21%)
		SH3_Myosin-I_fungi	1111..1162	CDD:212792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810