DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13397 and naglu

DIOPT Version :9

Sequence 1:	NP_001260251.1	Gene:	CG13397 / 46386	FlyBaseID:	FBgn0014417	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_688608.3	Gene:	naglu / 560126	ZFINID:	ZDB-GENE-100726-2	Length:	757	Species:	Danio rerio

Alignment Length:	764	Identity:	303/764 - (39%)
Similarity:	441/764 - (57%)	Gaps:	39/764 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALLAVLCLQLAQGSELNWDAASGPEMGLQMAAHLAPSTPKDVQETAAMAVISRVIGERSSQLFKV 74
            ||:|:|.:.|..       :..|   ..|..|||........|..|.:.::.|::|.|:.: |.|
Zfish     8 ALIALLFMTLLH-------SVCG---DFQTLAHLRAKASDKSQSRAVLDLLRRLLGNRARE-FIV 61

  Fly    75 QVNKNMDLRSFQISML---DDGRILLMGWDGVSVCKALHHYLKYVLNKDVDWFKMRIELPTNLQL 136
            .||:.:......:..|   .:.:::.:|..||:|...:::||||..|..|.|...::.||.  .|
Zfish    62 SVNRTLSADGLDVCELRSAKNNKVVAVGSTGVAVATGIYNYLKYFCNCHVSWAGDQLNLPR--PL 124

  Fly   137 PNVTIESKSASP--IIYHQNVCTWSYSFAWWGIEQWRRHLDWMALMGISLTIA-PVQEAIWVKVY 198
            |.:|...:.::|  ..|:|||||.|||..||...:|:|.:|||||.||:|.:| ..||.:|.:||
Zfish   125 PALTGVLRISTPHRFRYYQNVCTASYSSVWWDWPRWQREIDWMALNGINLPLAFTGQEVLWQEVY 189

  Fly   199 TDMGLRMEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPAWRRYQLLLQQEIITAQRNLGMSVALPA 263
            ..:||...|:|...:||||.||.||||:..|.|||..:|...||.||.:|:...|:.||...|||
Zfish   190 LSLGLNQTELDRFFSGPAFLAWNRMGNLFQWGGPLPQSWHVKQLYLQFKILDRMRSFGMIPVLPA 254

  Fly   264 FAGHVPRALKRLNPESTFMEVQRWNQFPDRYCCGLFVEPTENLFKEIASRFLHNIITKYGSNHIF 328
            |:|.||..:.||.|::...::..|:.|...|.|...::|.:.||..|.:.||..:|.::|::||:
Zfish   255 FSGIVPEGITRLFPKANVTKLSPWSHFNCTYSCAYVLDPRDPLFHRIGALFLTQVIEEFGTDHIY 319

  Fly   329 FCDPFNELEPPVAKPEYMRSTAAAIYESMRGIDPQAIWLLQGWMFVKNP-FWTTDMAEAFLTAAP 392
            ..|.|||:.|..:.|.|:.|.:.||:.:|..:|||||||:|||:|:.:| ||..|..:|.|...|
Zfish   320 NTDTFNEMPPASSDPTYLASISRAIFNTMTSVDPQAIWLMQGWLFISDPSFWKADQVKALLHGVP 384

  Fly   393 RGRILVLDLQSEQFPQYELTRSYFGQPFIWCMLHNFGGTLGMFGSAKLINSGIEEARRLPNSSLV 457
            .||::||||.:|..|.|..|.|::||||||||||||||..|:||:...||||...|.|.|||:||
Zfish   385 LGRMIVLDLFAESMPVYSSTNSFYGQPFIWCMLHNFGGNSGLFGTVDSINSGPFNAVRFPNSTLV 449

  Fly   458 GTGITPEGIGQNYVMYSFTLERGWSNTSLDLDSWFTNFSHSRYGVKDERLEQAWLLLKNSVYSFR 522
            |.|:|||||.||.|:|....|..|....::|..|.:.::..|||..||.|..||.||..|||:..
Zfish   450 GLGMTPEGIEQNPVIYELMSELAWRKDPVNLYKWVSLYALRRYGSMDENLALAWQLLFRSVYNCT 514

  Fly   523 GLQKMR--GQYVVTRRPSFNQEPFTWYNASAVLDAWHLLLTFRA---IIPLEDNRYEIYEHDLVD 582
             |.|.:  .:..:..|||.:.:...||:.:....||.||  |.|   ::.||..||     ||||
Zfish   515 -LPKYKNHNRSPLVHRPSLHMQTDIWYDPADFYRAWKLL--FEAAPGLVTLETFRY-----DLVD 571

  Fly   583 ITRQFLQISADQLYINLRSAYRKRQVSRFEFLS---VKLLKLFDDMELILASSRNFLLGNWLQQA 644
            :|||.||:...:.|.:::||::.:::|  :.|:   |.:..|..:::.||:|:.:||||.|||||
Zfish   572 VTRQALQLLTTEFYKDIKSAFQTQKLS--DLLTAGGVLVYDLLPELDRILSSNEHFLLGAWLQQA 634

  Fly   645 KQAAPNTGQQRNFEFNARNQITAWGPDGQILDYACKQWSGLVSDYYRPRWRLFLEDVTVALHAGR 709
            :....:..:...::.|||||||.|||||:|||||.|:|:|||.|||..||.||:..:...|..||
Zfish   635 QSQGVDEHEAHLYDINARNQITLWGPDGEILDYASKEWAGLVEDYYLQRWGLFVNTLVECLDRGR 699

  Fly   710 PFNGTAFKLKVSHEIELPFSNKDDVYPVTPVGNTWLISQDIFETWKGYS 758
            ||....|...| .::|..|......||..|:|:|:.|::.||..:..|:
Zfish   700 PFKQDVFNQAV-FQVEKGFVFNQRKYPTKPLGDTYDIARRIFLKYYPYA 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13397	NP_001260251.1	NAGLU_N	54..134	CDD:289723	22/82 (27%)
		NAGLU	151..483	CDD:282886	159/333 (48%)
		NAGLU_C	490..748	CDD:289724	103/265 (39%)
naglu	XP_688608.3	NAGLU_N	42..126	CDD:289723	23/86 (27%)
		NAGLU	140..475	CDD:282886	159/334 (48%)
		NAGLU_C	482..738	CDD:289724	103/266 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595977
Domainoid	1	1.000	340	1.000	Domainoid score	I1058
eggNOG	1	0.900	-	-		E1_KOG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H222
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1103
OMA	1	1.010	-	-		QHG62663
OrthoDB	1	1.010	-	-		D132992at33208
OrthoFinder	1	1.000	-	-		FOG0007516
OrthoInspector	1	1.000	-	-		oto40219
orthoMCL	1	0.900	-	-		OOG6_104279
Panther	1	1.100	-	-	LDO	PTHR12872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4327
SonicParanoid	1	1.000	-	-		X5645
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800