DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13397 and NAGLU

DIOPT Version :9

Sequence 1:	NP_001260251.1	Gene:	CG13397 / 46386	FlyBaseID:	FBgn0014417	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_024306539.1	Gene:	NAGLU / 4669	HGNCID:	7632	Length:	762	Species:	Homo sapiens

Alignment Length:	750	Identity:	302/750 - (40%)
Similarity:	422/750 - (56%)	Gaps:	42/750 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 MGLQMAAHLAPSTPKDVQETAAM-AVISRVIGERSSQLFKVQVNKNM----DLRSFQISMLDDGR 94
            :|:.:.|....:...:.:|.||: |:::|::|...:..|.|.|.:.:    .|.::.:......|
Human    10 VGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAAR 74

  Fly    95 ILLMGWDGVSVCKALHHYLKYVLNKDVDWFKMRIELPTNL-----QLPNVTIESKSASP------ 148
            :.:.|..||:....||.||:......|.|...::.||..|     :|...|....||.|
Human    75 VRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRASAGPPEKRKE 139

  Fly   149 --------IIYHQNVCTWSYSFAWWGIEQWRRHLDWMALMGISLTIA-PVQEAIWVKVYTDMGLR 204
                    ..|:|||||.||||.||...:|.|.:|||||.||:|.:| ..|||||.:||..:||.
Human   140 DAYRAVLLYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLT 204

  Fly   205 MEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPAWRRYQLLLQQEIITAQRNLGMSVALPAFAGHVP 269
            ..||:|...||||.||.||||:..|.|||.|:|...||.||..::...|:.||:..|||||||||
Human   205 QAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVP 269

  Fly   270 RALKRLNPESTFMEVQRWNQFPDRYCCGLFVEPTENLFKEIASRFLHNIITKYGSNHIFFCDPFN 334
            .|:.|:.|:....::..|..|...|.|...:.|.:.:|..|.|.||..:|.::|::||:..|.||
Human   270 EAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFN 334

  Fly   335 ELEPPVAKPEYMRSTAAAIYESMRGIDPQAIWLLQGWMFVKNP-FWTTDMAEAFLTAAPRGRILV 398
            |::||.::|.|:.:...|:||:|..:|.:|:||||||:|...| ||......|.|.|.||||:||
Human   335 EMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLV 399

  Fly   399 LDLQSEQFPQYELTRSYFGQPFIWCMLHNFGGTLGMFGSAKLINSGIEEARRLPNSSLVGTGITP 463
            |||.:|..|.|..|.|:.||||||||||||||..|:||:.:.:|.|.|.||..|||::||||:.|
Human   400 LDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAP 464

  Fly   464 EGIGQNYVMYSFTLERGWSNTSL-DLDSWFTNFSHSRYGVKDERLEQAWLLLKNSVYSFRGLQKM 527
            |||.||.|:||...|.||....: ||.:|.|:|:..||||.......||.||..|||:..| :..
Human   465 EGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSG-EAC 528

  Fly   528 RG--QYVVTRRPSFNQEPFTWYNASAVLDAWHLLLTFRAIIPLEDNRYEIYEHDLVDITRQFLQI 590
            ||  :..:.||||.......|||.|.|.:||.||||....:...    ..:.:||:|:|||.:|.
Human   529 RGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATS----PAFRYDLLDLTRQAVQE 589

  Fly   591 SADQLYINLRSAYRKRQVSRF----EFLSVKLLKLFDDMELILASSRNFLLGNWLQQAKQAAPNT 651
            .....|...||||..::::..    ..|:.:||...|:   :|||...||||:||:||:.||.:.
Human   590 LVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDE---VLASDSRFLLGSWLEQARAAAVSE 651

  Fly   652 GQQRNFEFNARNQITAWGPDGQILDYACKQWSGLVSDYYRPRWRLFLEDVTVALHAGRPFNGTAF 716
            .:...:|.|:|.|:|.|||:|.|||||.||.:|||::||.||||||||.:..::..|.||....|
Human   652 AEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQF 716

  Fly   717 KLKVSHEIELPFSNKDDVYPVTPVGNTWLISQDIF 751
            ...| .::|..|......||..|.|:|..:::.||
Human   717 DKNV-FQLEQAFVLSKQRYPSQPRGDTVDLAKKIF 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13397	NP_001260251.1	NAGLU_N	54..134	CDD:289723	21/84 (25%)
		NAGLU	151..483	CDD:282886	166/333 (50%)
		NAGLU_C	490..748	CDD:289724	102/263 (39%)
NAGLU	XP_024306539.1	NAGLU_N	42..115	CDD:315617	16/72 (22%)
		NAGLU	149..484	CDD:309985	166/334 (50%)
		NAGLU_C	493..747	CDD:315618	102/262 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159747
Domainoid	1	1.000	358	1.000	Domainoid score	I977
eggNOG	1	0.900	-	-		E1_KOG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H222
Inparanoid	1	1.050	546	1.000	Inparanoid score	I1160
Isobase	1	0.950	-	0	Normalized mean entropy	S4626
OMA	1	1.010	-	-		QHG62663
OrthoDB	1	1.010	-	-		D132992at33208
OrthoFinder	1	1.000	-	-		FOG0007516
OrthoInspector	1	1.000	-	-		oto91422
orthoMCL	1	0.900	-	-		OOG6_104279
Panther	1	1.100	-	-	LDO	PTHR12872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4327
SonicParanoid	1	1.000	-	-		X5645
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750