DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13397 and Naglu

DIOPT Version :9

Sequence 1:	NP_001260251.1	Gene:	CG13397 / 46386	FlyBaseID:	FBgn0014417	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_002727861.2	Gene:	Naglu / 360630	RGDID:	1564228	Length:	739	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	298/718 - (41%)
Similarity:	417/718 - (58%)	Gaps:	27/718 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DVQETAAM-AVISRVIGERSSQLFKVQVNKNM----DLRSFQISMLDDGRILLMGWDGVSVCKAL 109
            :.||..|: .::.|::|...:..|.|.|.:.:    .|.::.:|......:|:.|..||:....|
  Rat    23 EAQEAEAVRELVVRLLGPGPAADFLVSVERALANESGLDTYSLSGGGGVPVLVRGSSGVAAAAGL 87

  Fly   110 HHYLKYVLNKDVDWFKMRIELPTNLQLPNVTIESKSASP--IIYHQNVCTWSYSFAWWGIEQWRR 172
            |.||:......:.|...::.||:  .||.|......|:|  ..|:|||||.||||.||...:|.:
  Rat    88 HRYLRDFCGCHIAWSSSQLHLPS--PLPAVPDGLTEATPNRYRYYQNVCTHSYSFVWWDWARWEQ 150

  Fly   173 HLDWMALMGISLTIA-PVQEAIWVKVYTDMGLRMEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPA 236
            .:|||||.||:|.:| ..|||||.:||..:||...|||.:..||||.||.||||:..|.|||..:
  Rat   151 EIDWMALNGINLALAWNGQEAIWQRVYLALGLTQSEIDNYFTGPAFLAWGRMGNLHTWDGPLPRS 215

  Fly   237 WRRYQLLLQQEIITAQRNLGMSVALPAFAGHVPRALKRLNPESTFMEVQRWNQFPDRYCCGLFVE 301
            |...||.||..|:...|:.||:..|||||||||:|:.|:.|:...:::..|..|...|.|...:.
  Rat   216 WHLKQLYLQHRILDRMRSFGMTPVLPAFAGHVPKAITRVFPQVNVIQLGNWGHFNCSYSCSFLLA 280

  Fly   302 PTENLFKEIASRFLHNIITKYGSNHIFFCDPFNELEPPVAKPEYMRSTAAAIYESMRGIDPQAIW 366
            |.:.||..|.:.||..:..::|::||:..|.|||::||.:.|.|:.:..||:||:|..:||.|:|
  Rat   281 PGDPLFPLIGTLFLRELTKEFGTDHIYGADTFNEMQPPFSDPSYLAAATAAVYEAMVTVDPDAVW 345

  Fly   367 LLQGWMFVKNP-FWTTDMAEAFLTAAPRGRILVLDLQSEQFPQYELTRSYFGQPFIWCMLHNFGG 430
            |||||:|...| ||.....:|.|.|.||||:|||||.:|..|.|..|.|:.||||||||||||||
  Rat   346 LLQGWLFQHQPQFWGPSQIKAVLEAVPRGRLLVLDLFAETQPVYSRTASFHGQPFIWCMLHNFGG 410

  Fly   431 TLGMFGSAKLINSGIEEARRLPNSSLVGTGITPEGIGQNYVMYSFTLERGWSNTSL-DLDSWFTN 494
            ..|:||:.:.:|.|.:.||..|||::|||||.|||||||.|:|:...|.||....: ||.:|.::
  Rat   411 NHGLFGALEDVNQGPQAARLFPNSTMVGTGIAPEGIGQNEVVYALMAELGWRKDPVPDLVAWVSS 475

  Fly   495 FSHSRYGVKDERLEQAWLLLKNSVYSFRGLQKMRG--QYVVTRRPSFNQEPFTWYNASAVLDAWH 557
            |:..||||.......||.||..|||:..| :...|  :..:.:|||.......|||.|.|.:||.
  Rat   476 FASRRYGVSQPDAVAAWRLLLRSVYNCSG-EACSGHNRSPLVKRPSLQMSTAVWYNRSDVFEAWR 539

  Fly   558 LLLTFRAIIPLEDNRYEIYEHDLVDITRQFLQISADQLYINLRSAYRKRQVSRF----EFLSVKL 618
            |||  ||...|..:  ..:.:||:|:|||.:|......|...|:|:..:.:...    ..|:.||
  Rat   540 LLL--RAAPNLTAS--PAFRYDLLDVTRQAVQELVSSCYEEARTAFLNQDLDLLLRAGGLLTYKL 600

  Fly   619 LKLFDDMELILASSRNFLLGNWLQQAKQAAPNTGQQRNFEFNARNQITAWGPDGQILDYACKQWS 683
            |...|:   :|||:.:||||.||.||::.|.:..:.:.:|.|:|.|||.|||:|.|||||.||.:
  Rat   601 LPSLDE---LLASNSHFLLGTWLDQAREVAVSESEAQFYEQNSRYQITLWGPEGNILDYANKQLA 662

  Fly   684 GLVSDYYRPRWRLFLEDVTVALHAGRPFNGTAFKLKVSHEIELPFSNKDDVYPVTPVGNTWLISQ 748
            |||:|||:|||.|||..:..:|..|.||....|:..| ..:|..|.|....||:.|.|:|..:|:
  Rat   663 GLVADYYQPRWCLFLGTLAHSLARGIPFQQHQFEKSV-FPLEQAFINNKKRYPIQPQGDTVDLSK 726

  Fly   749 DIF 751
            .||
  Rat   727 KIF 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13397	NP_001260251.1	NAGLU_N	54..134	CDD:289723	19/84 (23%)
		NAGLU	151..483	CDD:282886	166/333 (50%)
		NAGLU_C	490..748	CDD:289724	101/263 (38%)
Naglu	XP_002727861.2	NAGLU_N	28..114	CDD:289723	20/87 (23%)
		NAGLU	128..463	CDD:282886	166/334 (50%)
		NAGLU_C	472..727	CDD:289724	102/263 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353813
Domainoid	1	1.000	359	1.000	Domainoid score	I937
eggNOG	1	0.900	-	-		E1_KOG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H222
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1142
OMA	1	1.010	-	-		QHG62663
OrthoDB	1	1.010	-	-		D132992at33208
OrthoFinder	1	1.000	-	-		FOG0007516
OrthoInspector	1	1.000	-	-		oto98500
orthoMCL	1	0.900	-	-		OOG6_104279
Panther	1	1.100	-	-	LDO	PTHR12872
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5645
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770