DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13397 and K09E4.4

DIOPT Version :9

Sequence 1:	NP_001260251.1	Gene:	CG13397 / 46386	FlyBaseID:	FBgn0014417	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_496948.2	Gene:	K09E4.4 / 175063	WormBaseID:	WBGene00010722	Length:	715	Species:	Caenorhabditis elegans

Alignment Length:	764	Identity:	233/764 - (30%)
Similarity:	379/764 - (49%)	Gaps:	88/764 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLNWKLALALLAVLC----------LQLAQGSELNWDAASGPEMGLQMAAHLAPSTPKDVQETA 55
            |..::.:|| |:.|||          :||....:.:|.:         :...:||...  ::|.|
Worm     1 MPRHFHVAL-LILVLCGAERARGALRVQLQDYDKNSWRS---------VLRRVAPEWV--LEEFA 53

  Fly    56 AMAVISRVIGERSSQLFK-----VQVNKNMDLRSFQISMLDDGRILLMGWDGVSVCKALHHYLKY 115
            .:.|:|  ..|...||.|     :::||:             ||..:..........|::.||:.
Worm    54 DVKVLS--AAENGFQLPKSGLAQIEINKS-------------GRKTVTANTPTDALNAINTYLRT 103

  Fly   116 VLNKDVDWFKMRIELPTNLQLPN-VTIESKSASPIIYHQNVCTWSYSFAWWGIEQWRRHLDWMAL 179
            .....|.|...........:..: :..|||.   |.|..|:||:|||||||...||.|.:||:||
Worm   104 ECLSQVSWSNSSFSSGCRKRTSDFINFESKQ---IRYFGNMCTFSYSFAWWEWPQWERFIDWIAL 165

  Fly   180 MGISLTIAPV-QEAIWVKVYTDMGLRMEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPAWRRYQLL 243
            .|.:..:.|: ||.||..::..:|::.:|:|.:....|:.||.||||::.:.|.|:.|    |:|
Worm   166 NGFNTVLMPLGQEIIWRDIFMGLGVQRDELDSYFTSQAYLAWHRMGNLKAYGGGLSDA----QML 226

  Fly   244 ----LQQEIITAQRNLGMSVALPAFAGHVPRALKRLNPESTFMEVQRWNQFPDRYCCGLFVEPTE 304
                |.:.||.....||::..||.|||.||..|:.|.|.|.|..:.|||.|.....|.|.|.|.:
Worm   227 NDHNLAKRIIDRLLELGITPILPTFAGFVPDHLETLFPASKFNRLPRWNNFTSETSCMLSVSPFD 291

  Fly   305 NLFKEIASRFLHNIITKYGSN--HIFFCDPFNELEPPVA---KPEYMRSTAAAIYESMRGIDPQA 364
            .||::|.|.||.:....:|.:  :::..|||||:.|..:   ..::::.||.||..|.:.:|...
Worm   292 PLFQKIGSTFLRHQKKMFGGDVTNMYSADPFNEILPSESAKFDAKFVKQTAQAIMNSCKKVDKNC 356

  Fly   365 IWLLQGWMFVKN--PFWTTDMAEAFLTAAPRGRILVLDLQSEQFPQYELTRSYFGQPFIWCMLHN 427
            :|:||.|.|..:  |.|.   .::||:|.|.|.:|:|||.:|..|.:::|.|:.|..|:||:|||
Worm   357 VWVLQSWSFTYDQWPAWA---IKSFLSAIPVGNLLILDLYAEVVPAWQMTSSFQGHHFVWCLLHN 418

  Fly   428 FGGTLGMFGSAKLINSGIEEARRLPNSSLVGTGITPEGIGQNYVMYSFTLERGWSNTSLDLDSWF 492
            |||:..:.|:.:.|:.|.:.|.....|:|||.|::.|.|.||||:|.|.::|.||...|.|::|.
Worm   419 FGGSRELRGNLQKIDKGYQLALMKAGSNLVGAGLSMEAIDQNYVVYQFMIDRMWSPEPLPLNNWL 483

  Fly   493 TNFSHSRYGVKDERLEQAWLLLKNSVYSFRGLQKM---RGQYVVTRRPSFNQEPFTWYNASAVLD 554
            ..:|.|||....:..::.|.||..:.|:  ..:|.   |....:..||.|.::...|:.......
Worm   484 KAYSESRYSADFKVAQKFWTLLAGTFYN--QPEKWGTPRFSVFLYHRPGFGRKIEYWFPVEETFS 546

  Fly   555 AWHLLLTFRAIIPLEDN---RYEIYEHDLVDITRQFLQIS-ADQLYINLRSAYRKRQVSRFEFLS 615
                  .||.::|...:   .:.::..||.|:.|:..|.. .::..:::..|:......:.....
Worm   547 ------RFRELLPALVHVLGEHPLFREDLNDVMREMTQFEMGNEAALSMSEAFLMEDKQQVGASC 605

  Fly   616 VKLLKLFDDMELILASSRNFLLGNWLQQAKQAAPNTGQQRNFEFNARNQITAWGPDGQILDYACK 680
            ..|:::|..:|    |..|..:..|::.||..||.:.:::.|...|.:.:|.|||.||.||||.:
Worm   606 EMLMEMFQKLE----SYSNRDVRQWIENAKSIAPTSEERQVFPVTAGDILTVWGPTGQNLDYAHR 666

  Fly   681 QWSGLVSDYYRPRWRLFLEDVTVALHAGRPFNGTAFKLKVSHEIELPFS 729
            :|:||:|.||..||:.|.:  .:..|  ..||.|.|.:.|..::|.|||
Worm   667 EWAGLMSGYYGRRWQYFCD--WILEH--DDFNHTEFSISVFRDVERPFS 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13397	NP_001260251.1	NAGLU_N	54..134	CDD:289723	16/84 (19%)
		NAGLU	151..483	CDD:282886	132/343 (38%)
		NAGLU_C	490..748	CDD:289724	65/247 (26%)
K09E4.4	NP_496948.2	NAGLU	136..474	CDD:282886	132/344 (38%)
K09E4.4	NP_496948.2	NAGLU_C	481..710	CDD:289724	62/244 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167280
Domainoid	1	1.000	259	1.000	Domainoid score	I1070
eggNOG	1	0.900	-	-		E1_KOG2233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I1301
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62663
OrthoDB	1	1.010	-	-		D132992at33208
OrthoFinder	1	1.000	-	-		FOG0007516
OrthoInspector	1	1.000	-	-		oto19338
orthoMCL	1	0.900	-	-		OOG6_104279
Panther	1	1.100	-	-	LDO	PTHR12872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4327
SonicParanoid	1	1.000	-	-		X5645
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.840