Protein Alignment Naglu and K09E4.4

DIOPT Version :10

• Sequence 1: NP_652045.1
• Gene: Naglu / 46386
• FlyBaseID: FBgn0014417
• Length: 778
• Species: Drosophila melanogaster
• Sequence 2: NP_496948.2
• Gene: K09E4.4 / 175063
• WormBaseID: WBGene00010722
• Length: 715
• Species: Caenorhabditis elegans
• Alignment Length: 764
• Identity: 233/764 - (30%)
• Similarity: 379/764 - (49%)
• Gaps: 88/764 - (11%)

  Fly     1 MQLNWKLALALLAVLC----------LQLAQGSELNWDAASGPEMGLQMAAHLAPSTPKDVQETA 55
            |..::.:|| |:.|||          :||....:.:|.:         :...:||...  ::|.|
 Worm     1 MPRHFHVAL-LILVLCGAERARGALRVQLQDYDKNSWRS---------VLRRVAPEWV--LEEFA 53

  Fly    56 AMAVISRVIGERSSQLFK-----VQVNKNMDLRSFQISMLDDGRILLMGWDGVSVCKALHHYLKY 115
            .:.|:|  ..|...||.|     :::||:             ||..:..........|::.||:.
 Worm    54 DVKVLS--AAENGFQLPKSGLAQIEINKS-------------GRKTVTANTPTDALNAINTYLRT 103

  Fly   116 VLNKDVDWFKMRIELPTNLQLPN-VTIESKSASPIIYHQNVCTWSYSFAWWGIEQWRRHLDWMAL 179
            .....|.|...........:..: :..|||.   |.|..|:||:|||||||...||.|.:||:||
 Worm   104 ECLSQVSWSNSSFSSGCRKRTSDFINFESKQ---IRYFGNMCTFSYSFAWWEWPQWERFIDWIAL 165

  Fly   180 MGISLTIAPV-QEAIWVKVYTDMGLRMEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPAWRRYQLL 243
            .|.:..:.|: ||.||..::..:|::.:|:|.:....|:.||.||||::.:.|.|:.|    |:|
 Worm   166 NGFNTVLMPLGQEIIWRDIFMGLGVQRDELDSYFTSQAYLAWHRMGNLKAYGGGLSDA----QML 226

  Fly   244 ----LQQEIITAQRNLGMSVALPAFAGHVPRALKRLNPESTFMEVQRWNQFPDRYCCGLFVEPTE 304
                |.:.||.....||::..||.|||.||..|:.|.|.|.|..:.|||.|.....|.|.|.|.:
 Worm   227 NDHNLAKRIIDRLLELGITPILPTFAGFVPDHLETLFPASKFNRLPRWNNFTSETSCMLSVSPFD 291

  Fly   305 NLFKEIASRFLHNIITKYGSN--HIFFCDPFNELEPPVA---KPEYMRSTAAAIYESMRGIDPQA 364
            .||::|.|.||.:....:|.:  :::..|||||:.|..:   ..::::.||.||..|.:.:|...
 Worm   292 PLFQKIGSTFLRHQKKMFGGDVTNMYSADPFNEILPSESAKFDAKFVKQTAQAIMNSCKKVDKNC 356

  Fly   365 IWLLQGWMFVKN--PFWTTDMAEAFLTAAPRGRILVLDLQSEQFPQYELTRSYFGQPFIWCMLHN 427
            :|:||.|.|..:  |.|.   .::||:|.|.|.:|:|||.:|..|.:::|.|:.|..|:||:|||
 Worm   357 VWVLQSWSFTYDQWPAWA---IKSFLSAIPVGNLLILDLYAEVVPAWQMTSSFQGHHFVWCLLHN 418

  Fly   428 FGGTLGMFGSAKLINSGIEEARRLPNSSLVGTGITPEGIGQNYVMYSFTLERGWSNTSLDLDSWF 492
            |||:..:.|:.:.|:.|.:.|.....|:|||.|::.|.|.||||:|.|.::|.||...|.|::|.
 Worm   419 FGGSRELRGNLQKIDKGYQLALMKAGSNLVGAGLSMEAIDQNYVVYQFMIDRMWSPEPLPLNNWL 483

  Fly   493 TNFSHSRYGVKDERLEQAWLLLKNSVYSFRGLQKM---RGQYVVTRRPSFNQEPFTWYNASAVLD 554
            ..:|.|||....:..::.|.||..:.|:  ..:|.   |....:..||.|.::...|:.......
 Worm   484 KAYSESRYSADFKVAQKFWTLLAGTFYN--QPEKWGTPRFSVFLYHRPGFGRKIEYWFPVEETFS 546

  Fly   555 AWHLLLTFRAIIPLEDN---RYEIYEHDLVDITRQFLQIS-ADQLYINLRSAYRKRQVSRFEFLS 615
                  .||.::|...:   .:.::..||.|:.|:..|.. .::..:::..|:......:.....
 Worm   547 ------RFRELLPALVHVLGEHPLFREDLNDVMREMTQFEMGNEAALSMSEAFLMEDKQQVGASC 605

  Fly   616 VKLLKLFDDMELILASSRNFLLGNWLQQAKQAAPNTGQQRNFEFNARNQITAWGPDGQILDYACK 680
            ..|:::|..:|    |..|..:..|::.||..||.:.:::.|...|.:.:|.|||.||.||||.:
 Worm   606 EMLMEMFQKLE----SYSNRDVRQWIENAKSIAPTSEERQVFPVTAGDILTVWGPTGQNLDYAHR 666

  Fly   681 QWSGLVSDYYRPRWRLFLEDVTVALHAGRPFNGTAFKLKVSHEIELPFS 729
            :|:||:|.||..||:.|.:  .:..|  ..||.|.|.:.|..::|.|||
 Worm   667 EWAGLMSGYYGRRWQYFCD--WILEH--DDFNHTEFSISVFRDVERPFS 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naglu	NP_652045.1	NAGLU_N	54..134	CDD:463762	16/84 (19%)
		NAGLU	151..483	CDD:461545	132/343 (38%)
		NAGLU_C	491..748	CDD:463763	65/246 (26%)
K09E4.4	NP_496948.2	NAGLU	136..474	CDD:461545	132/344 (38%)
		NAGLU_C	482..710	CDD:463763	62/243 (26%)