DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13397 and naglu

DIOPT Version :9

Sequence 1:	NP_001260251.1	Gene:	CG13397 / 46386	FlyBaseID:	FBgn0014417	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_031758141.1	Gene:	naglu / 100489327	XenbaseID:	XB-GENE-6030768	Length:	759	Species:	Xenopus tropicalis

Alignment Length:	767	Identity:	294/767 - (38%)
Similarity:	431/767 - (56%)	Gaps:	25/767 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALLAVLCLQLAQGSELNWDAASGPEMGLQMAAHLAPSTPKDVQETAAMAVISRVIGERSSQLFKV 74
            |||.:|.|..::        ...|.......:||.|....|||..|...:::|::|.|:|: |.|
Frog     4 ALLVLLLLSCSE--------TVVPTRVFPALSHLKPQKGDDVQTAAVRELLARLLGGRASE-FSV 59

  Fly    75 QVNKNM---DLRSFQISMLDDGRILLMGWDGVSVCKALHHYLKYVLNKDVDWFKMRIELPTNLQL 136
            .||.::   ...::::|....|.:|::|..||:.....:.|||......:.|...:::||.  .|
Frog    60 TVNSSLAEGGRDTYRLSSGAGGTVLVVGSSGVAAASGCYTYLKAFCGAHLSWSGAQLQLPP--AL 122

  Fly   137 PNVTIESKSASP--IIYHQNVCTWSYSFAWWGIEQWRRHLDWMALMGISLTIA-PVQEAIWVKVY 198
            |.|......::|  ..|:|||||.||||.||...:|.:.:|||||.||::.:| ..|||||.|||
Frog   123 PPVPAPLTRSAPHRFHYYQNVCTSSYSFVWWDWARWEKEIDWMALSGINMPLAFTGQEAIWYKVY 187

  Fly   199 TDMGLRMEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPAWRRYQLLLQQEIITAQRNLGMSVALPA 263
            ..:||...||.:...||||.||.|||||..|.|||:.:|...:|.||.:|....|:|||...|||
Frog   188 LSLGLNESEIFDFFTGPAFLAWGRMGNIHTWGGPLSISWMEKRLSLQLQITERMRSLGMITVLPA 252

  Fly   264 FAGHVPRALKRLNPESTFMEVQRWNQFPDRYCCGLFVEPTENLFKEIASRFLHNIITKYGSNHIF 328
            ||||:|..:.|:.|:.|...:..|:.|...|.|...::|.:.||:.|...||..::..:|::||:
Frog   253 FAGHIPEGILRVFPKVTVSRLGGWSNFNCTYSCSYLLDPEDPLFQWIGELFLSQMVQSFGTDHIY 317

  Fly   329 FCDPFNELEPPVAKPEYMRSTAAAIYESMRGIDPQAIWLLQGWMFVKNP-FWTTDMAEAFLTAAP 392
            ..|.|||:.|..:.|.|:.:.:.||::||..:||.||||:|||:|:.|| ||.....:|.|..||
Frog   318 SADTFNEMSPTSSDPGYLSAVSGAIFKSMAKVDPDAIWLMQGWLFINNPSFWQPAQTKALLHGAP 382

  Fly   393 RGRILVLDLQSEQFPQYELTRSYFGQPFIWCMLHNFGGTLGMFGSAKLINSGIEEARRLPNSSLV 457
            .|||:||||.:|..|.|..|.|::|||||||||:||||..|:||:.:.:|.|..:|.:.|||::|
Frog   383 IGRIIVLDLFAETVPVYLTTESFYGQPFIWCMLNNFGGNHGLFGNIEGVNRGPFDAAKFPNSTMV 447

  Fly   458 GTGITPEGIGQNYVMYSFTLERGWSNTSLDLDSWFTNFSHSRYGVKDERLEQAWLLLKNSVYSFR 522
            |||:|||||.||.::|.|..|.|||:..::|..|.:|:|..|||..:.....||.:|..|||:..
Frog   448 GTGLTPEGIEQNDMIYEFMNEIGWSSQPINLTKWISNYSDRRYGQSNTDARMAWQILLRSVYNCT 512

  Fly   523 GLQKMRGQYVVTRRPSFNQEPFTWYNASAVLDAWHLLLTFRAIIPLEDNRYEIYEHDLVDITRQF 587
            .:........:.||||.|......||.:.:.:||..:  ..|...|..:...:|  |||||||:.
Frog   513 QILHNHNHSPLVRRPSLNMNTDICYNKADIYEAWRFM--HNASFALGKSATFLY--DLVDITREA 573

  Fly   588 LQISADQLYINLRSAYRKRQVSRFEFL-SVKLLKLFDDMELILASSRNFLLGNWLQQAKQAAPNT 651
            :|....:.|:.::.||.|:.:.:.... .|.:..|..:::.:|:|...||||:||:.||..|...
Frog   574 VQQLVSEYYLEIKEAYGKKSLQQLMTAGGVLVYDLLPELDSLLSSQPGFLLGSWLKAAKSMASTP 638

  Fly   652 GQQRNFEFNARNQITAWGPDGQILDYACKQWSGLVSDYYRPRWRLFLEDVTVALHAGRPFNGTAF 716
            .:...::.|||||||.|||.|.|||||.||:.|||.|||..||.||:..:..:|:.|..||...|
Frog   639 AEAALYDMNARNQITLWGPTGNILDYANKQYGGLVQDYYTERWGLFVWFLVQSLNKGEHFNQDKF 703

  Fly   717 KLKVSHEIELPFSNKDDVYPVTPVGNTWLISQDIFETWKGYSKDTLFLHNNR 768
            . |....:|..|......|..:|.|:|..|:..|:..::.|::.. ||..|:
Frog   704 N-KAVFVLEEDFVYNGKEYMASPTGDTLEIANKIYLKYQPYARKR-FLRRNK 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13397	NP_001260251.1	NAGLU_N	54..134	CDD:289723	21/82 (26%)
		NAGLU	151..483	CDD:282886	160/333 (48%)
		NAGLU_C	490..748	CDD:289724	90/258 (35%)
naglu	XP_031758141.1	NAGLU_N	40..113	CDD:404008	19/73 (26%)
		NAGLU	139..473	CDD:398659	160/333 (48%)
		NAGLU_C	481..734	CDD:404009	90/257 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H222
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132992at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010