DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYLK and TPK2

DIOPT Version :9

Sequence 1:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens
Sequence 2:	NP_015121.1	Gene:	TPK2 / 855898	SGDID:	S000006124	Length:	380	Species:	Saccharomyces cerevisiae

Alignment Length:	340	Identity:	89/340 - (26%)
Similarity:	161/340 - (47%)	Gaps:	41/340 - (12%)

- Green bases have known domain annotations that are detailed below.

Human  1427 QESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQK---------VSDFYDIEERLGS 1482
            |:..:.|.|:...:|..:::.....:::.: ..:.:|....||         :.|| .|...||:
Yeast    16 QQQNVNTYGQGVLQPHHDLQQRQQQQQQRQ-HQQLLTSQLPQKSLVSKGKYTLHDF-QIMRTLGT 78

Human  1483 GKFGQVFRLVEKKTRKVWAGKFF--------KAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFE 1539
            |.||:| .||    |.|..|:::        :....|:.|:...|..::..:.||.|::....|:
Yeast    79 GSFGRV-HLV----RSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQ 138

Human  1540 EKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1604
            :..||.||::.:.|||||. ::.:...........|..::...:||:|...|::.|||||||: :
Yeast   139 DARNIFMVMDYIEGGELFS-LLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENIL-L 201

Human  1605 NKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLS 1669
            ::.| .||:.|||.|:.::..  ...|.|||:::|||||..:|...:.|.||:||:.|.:::|.:
Yeast   202 DRNG-HIKITDFGFAKEVQTV--TWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYT 263

Human  1670 PFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQ-----CLQHPWL 1729
            ||......:|...:......:.    .....|..|.:|.|:..|:..|:...|     ...|||.
Yeast   264 PFYDTTPMKTYEKILQGKVVYP----PYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF 324

Human  1730 MKDTKNMEAKKLSKD 1744
               ::.:..:.|:||
Yeast   325 ---SEVVWERLLAKD 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352
		Ig8_hMLCK_like	1248..1345	CDD:143239
		FN3	1341..1433	CDD:238020	1/5 (20%)
		STKc_MLCK1	1471..1729	CDD:271093	78/270 (29%)
		I-set	1819..1909	CDD:254352
TPK2	NP_015121.1	STKc_PKA_like	69..358	CDD:270732	82/286 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910