DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYLK and mylkb

DIOPT Version :9

Sequence 1:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens
Sequence 2:	XP_009300538.1	Gene:	mylkb / 492576	ZFINID:	ZDB-GENE-041111-150	Length:	966	Species:	Danio rerio

Alignment Length:	1018	Identity:	605/1018 - (59%)
Similarity:	732/1018 - (71%)	Gaps:	82/1018 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   934 DFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKK-GTSKTPVPEKVPPPKPATPDFRSVLGG 997
            ||||.|:....||..|  |.|..:|.:|||||:|.|| |:||.||  ...||.....||||||..
Zfish     3 DFRAALKPSSGPKPGS--EIKTSTPAKVDFRSLLNKKDGSSKAPV--ATTPPSRGPSDFRSVLSK 63

Human   998 KKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGN 1062
            |:.              |::|::.:...|:....|..|....:........|......|||
Zfish    64 KQA--------------AESVKTEEKEQNSTKPAPKTPQKEKQSGVNGVNGGAVDKKSTLK---- 110

Human  1063 AKPDENLKSASKEELKKDVKNDVNC----------KRGHAG--TTDNEKR-----SESQGTAPAF 1110
                ||..:.::   |||.|.|...          |:...|  |..|:|:     .:..|..|.|
Zfish   111 ----ENTTTTTE---KKDSKTDAGTIGKKEKSSPEKKTSDGQITESNDKKVVNGGEKDAGKPPVF 168

Human  1111 KQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR 1175
            ||.|.|:.|.:|::|.|:|||:||..|.|.|.|:|||:|.:|||:||.||..||::|:||||||.
Zfish   169 KQPLSDITVVDGERLRLECQVTSDLQAAITWILDGKTVKPSKFIVLSHEGEKCSLTIDKALPEDE 233

Human  1176 GLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKT 1240
            |.|.|.|:|..|:|||||.||||| |:..:.   :.|:|:..|:.|.   ||::|.:|||||
Zfish   234 GRYTCRAENAHGKAECSCVVTVDD-PSDPSA---DKKNRKSSSATPT---TENEARIKKKPA--- 288

Human  1241 PPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESE-HMKVENSENGSK 1304
            |.|...|||.:.||.|||:||||.|||.|...|:.||||||:||:|.||... .:.:|.:||.|:
Zfish   289 PTKQGSPPQFLHFPGDQKIRAGEKVELLGNFGGSPPITCTWLKFKKPIQPGNGGISIETTENSSQ 353

Human  1305 LTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDG 1369
            |||.|:.|:|||||||.::||.|.:||.:|||:|||||||||.|.|||||.|||||||||.:|||
Zfish   354 LTIAASDQDHCGCYTLELQNKFGLKQASLNLTIVDKPDPPAGIPAASDIRRSSLTLSWYGPTYDG 418

Human  1370 GSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV 1434
            ||.||||::|||:|.:.||.:|.:|.||||:||:||.|.:|||||||:||||..|||.||....|
Zfish   419 GSIVQSYNLEIWNSVDNTWNDLTSCNSTSFHVQNLLSDRQYKFRVRAVNVYGVGEPSAESGPIEV 483

Human  1435 G-EKPEEPKDEVEV-----SDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVE 1493
            | |:..|.|:|.||     .||:|||||  ||.|.|..:..|.||||||:|||:|||||||:|||
Zfish   484 GAEEVTEKKEEEEVGAAVSDDDEEKEPE--YRDVVIKKDCSVKDFYDIEDRLGTGKFGQVFKLVE 546

Human  1494 KKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFE 1558
            |.::|||||||.||:|.|||||:||||.|||.|||||||||:||||.|:::|||:|::|||||||
Zfish   547 KSSKKVWAGKFIKAFSQKEKENVRQEIGIMNSLHHPKLVQCMDAFEGKSDMVMVMEMISGGELFE 611

Human  1559 RIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLE 1623
            ||:||||||||||.||||.||.:||::||||||||||||||||||:||||::|||||||||||||
Zfish   612 RIVDEDFELTEREVIKYMLQIIDGVQFIHKQGIVHLDLKPENIMCINKTGSKIKLIDFGLARRLE 676

Human  1624 NAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATW 1688
            ::|||||||||||||||||||||.|.|.|||||||||||||||||||||||||||||||||||||
Zfish   677 DSGSLKVLFGTPEFVAPEVINYEAISYPTDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATW 741

Human  1689 DFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR 1753
            ||:|||||||||.||||||.||||||:.||.|.||.:|.||.:||||||||:|||:|||||:.||
Zfish   742 DFEDEAFDEISDQAKDFISRLLKKDMRARLTCAQCFEHSWLKQDTKNMEAKQLSKERMKKYILRR 806

Human  1754 KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPH-- 1816
            :|||||||||||.|.|||.|:.|:..:||   |||          ||:....|||:| |::.|
Zfish   807 RWQKTGNAVRAISRFSSMGMLGGIGPKKS---SPT----------EEEPPAPFLESV-EDENHTP 857

Human  1817 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISD 1881
            ..|.|:..|:|:||||||||||||||||.|||||||:||||.|:|:|||||||:|||:|||:||:
Zfish   858 AAPSFASVIQDVEVVEGSAARFDCKIEGCPDPEVVWYKDDQPIKETRHFQIDYEEDGHCSLVISE 922

Human  1882 VCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE 1924
            ||.||||||||||||.||||:|||||:||.|:|.||:.|.|||
Zfish   923 VCPDDDAKYTCKAVNGLGEASCTAELMVEFMQEEEGDAEGEEE 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352	51/88 (58%)
		Ig8_hMLCK_like	1248..1345	CDD:143239	57/97 (59%)
		FN3	1341..1433	CDD:238020	63/91 (69%)
		STKc_MLCK1	1471..1729	CDD:271093	211/257 (82%)
		I-set	1819..1909	CDD:254352	71/89 (80%)
mylkb	XP_009300538.1	I-set	166..255	CDD:254352	51/88 (58%)
		IGc2	180..245	CDD:197706	37/64 (58%)
		Ig	296..394	CDD:299845	57/97 (59%)
		I-set	296..386	CDD:254352	50/89 (56%)
		FN3	390..475	CDD:238020	59/84 (70%)
		PKc_like	524..782	CDD:304357	211/257 (82%)
		Pkinase	527..782	CDD:278497	209/254 (82%)
		I-set	860..950	CDD:254352	71/89 (80%)
		IGc2	873..940	CDD:197706	55/66 (83%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338230
Domainoid	1	1.000	458	1.000	Domainoid score	I3420
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14202
Inparanoid	1	1.050	1158	1.000	Inparanoid score	I1742
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23643at7742
OrthoFinder	1	1.000	-	-		FOG0007119
OrthoInspector	1	1.000	-	-		otm27865
orthoMCL	1	0.900	-	-		OOG6_104679
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4882
SonicParanoid	1	1.000	-	-		X3431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	14	14.190