DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYLK and bt

DIOPT Version :9

Sequence 1:XP_024309300.1 Gene:MYLK / 4638 HGNCID:7590 Length:1924 Species:Homo sapiens
Sequence 2:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster


Alignment Length:2163 Identity:518/2163 - (23%)
Similarity:794/2163 - (36%) Gaps:609/2163 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    13 DVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWH 77
            |.:::|.:...::    ||:......|...|..|  |....|..|..:..:.....:.:|:   |
  Fly  6724 DFRVIAENKYGQS----DPANTSEPILARHPFDI--PNTPGIPHGIDSTEDSITIAWTKPK---H 6779

Human    78 RNGQPITS---GGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSF-- 137
            ..|.|||.   ..|.|.|    ..::..:||:..:    .:|:..|       .:| ..|..|  
  Fly  6780 DGGSPITGYIIEKRLLSD----DKWTKAVHALCPD----LSCKIPN-------LIE-NAEYEFRV 6828

Human   138 --AKQLGQPVVSKTLGDRFSAPAVETRPSIWGECP--PKFATKLG--RVVVKEGQMGRFSCKITG 196
              ....||...|.:....|.     .||      |  ||..:.|.  .:.|..|...|.:.....
  Fly  6829 AAVNAAGQSAYSGSSDLIFC-----RRP------PHAPKITSDLSIRDMTVIAGDEFRITVPYHA 6882

Human   197 RPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI- 260
            .|:|..:|....:.:.|..|:.....:...:.......:|:.|.||..:.|..|..:.|..::: 
  Fly  6883 SPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVV 6947

Human   261 ------QG----LDSANRSFVRETKATNSDVRKEVTNVISKESKLDS----LEAAAKSKNCSSPQ 311
                  ||    .|....:.....|....|....:||.:.:  |||:    ::.::..:|.....
  Fly  6948 DRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVE--KLDNSGSWVKISSFVRNTHYDV 7010

Human   312 RGGSPPWAANSQPQPPRESKLESCKD--------SPRTAPQTP----VLQKTSSSITLQAARVQP 364
            .|..|.:..|.:.:...:..|....|        ...|.|..|    |:...|.::||    :..
  Fly  7011 MGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDSGNVTL----IWT 7071

Human   365 EPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPG--LGSQDVVSKAANRRIPMEGQRDSAFPKF- 426
            .|       ||..|               :|..|  :..:|:::             ||::..: 
  Fly  7072 RP-------LSDGG---------------SRIQGYQIEYRDILN-------------DSSWNAYD 7101

Human   427 ----ESKPQSQEVKENQTVKFRCE---VSGIPK---PEVAWFLEGT-PVRRQEGSIEV------- 473
                ::|.|...:......:||.:   .:|:.|   |.:.:.|:|. .|....|:.:|       
  Fly  7102 YIIKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNY 7166

Human   474 --------YEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQ--VER------------ 516
                    ..|.||.....:..| ||.|.......|....|...:|:.  :|.            
  Fly  7167 VDLKWEKPLRDGGSRITGYIIER-RDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFAVNS 7230

Human   517 ------------LAVMEV----APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQ 565
                        :.|.||    .|.:.:.|:|.....|:|:.|||:..|.|.|...||.||:.||
  Fly  7231 AGRSEPSLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQ 7295

Human   566 Y--ARSTCEA--GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVA 626
            .  .|.||::  ||..|||.:....|.|.|||.|.|:||.|:.|.::.:                
  Fly  7296 MNGGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLKI---------------- 7344

Human   627 PSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI--QESEDFHFEQR--GTQ 687
               .:.||..:..|:||:.:|....:.:..||:.|..|| |...||:  ..::|.|.:..  ...
  Fly  7345 ---GSPPIINRCPSELKLPEGDNSKIKIFYSGDQPLTVI-LKKNNEVICDSNDDTHVKVNIFDDY 7405

Human   688 HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ-EPHDGTQPWFIS-----------KPRSV 740
            .::.|:.:...|.|.|..|..|.:|....:..:.:. .|...|.|..||           :|.|.
  Fly  7406 VAIYIRNIVKSDGGPYQIEFTNESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWRPPSY 7470

Human   741 TASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEV---LQNEDVFTLVLKKVQPWHAGQY 802
            ...|..|..:   |......:.||: ...:.||||. |.|   ::|::....|            
  Fly  7471 DGGLKVSHYV---IERKDVSSPHWI-TVSSTCKDTA-FNVQGLIENQEYIFRV------------ 7518

Human   803 EILLKNRVGECSCQVSLMLQNSSARALP-------RGREPASCEDLCGGGVGADGGGSDRYGSLR 860
                             |..|.:....|       |.::|.......|.....:.||.    .:.
  Fly  7519 -----------------MAVNENGMGPPLEGLNPIRAKDPIDPPSPPGSPQITEIGGD----FVH 7562

Human   861 PGWPARGQGWLEEEDGEDVRG--VLKRRV--ETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLS 921
            ..|...     |.:.|..::|  :.||.|  .|.|.....|  ....|::..:|           
  Fly  7563 LEWEKP-----ESDGGAHIQGYWIDKREVGSNTWQRVNATI--CAANQINCINL----------- 7609

Human   922 EDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKP 986
                  |...|.:||...|......|.|...:.|                        |:..|:.
  Fly  7610 ------IEGRQYEFRIFAQNVAGLSTESSASQAV------------------------KIIDPQA 7644

Human   987 ATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNA 1051
            |:|                                          ||                  
  Fly  7645 ASP------------------------------------------PL------------------ 7649

Human  1052 KPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQD 1116
                .:||:                      .|.||.:.|          .:|.|          
  Fly  7650 ----IVKPL----------------------RDANCIQNH----------NAQFT---------- 7668

Human  1117 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 1181
                        |.::..|..||.|....:.:.......:..||....::|.....||...|.|.
  Fly  7669 ------------CTINGVPKPTISWYKGAREISNGARYHMYSEGDNHFLNINDVFGEDADEYVCR 7721

Human  1182 AKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAM 1246
            |.|.||                       .||.|              ||:    |..|.||..:
  Fly  7722 AVNKAG-----------------------AKSTR--------------ATL----AIMTAPKLNV 7745

Human  1247 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAAR 1311
            ||   :|.:......||:|.:....||.......|::..:.|:...|..||..|..:.|.|....
  Fly  7746 PP---RFRDTAYFDKGENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVKERHAVLIIRDGS 7807

Human  1312 QEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1376
            ....|.|.:..||:|||..|.:.:.:.|:||||. .|....|.:.||:|||....:||.|.:.:|
  Fly  7808 HLDSGPYRITAENELGSDTAIIQVQISDRPDPPR-FPLIESIGTESLSLSWKAPVWDGCSDITNY 7871

Human  1377 SIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESEL----TTVGEK 1437
            .:|..:....:|..:...|.||..|..|.|..||.||:.|.||||.|:.|..|.|    .:|.:|
  Fly  7872 YVERREHPLSSWIRVGNTRFTSMAVSGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKK 7936

Human  1438 PEEPKDEVEVSD----DDEKEPEVDYRTVTIN------------TEQKVSDFYDIEERLGSGKFG 1486
            |.|.|.|::.:.    .....|..||.:...:            ::|.|.|.|||.|.:|:|.||
  Fly  7937 PIERKWEIDANGRKLRGKADGPVKDYDSYVFDIYSKFVPQPVEISQQSVYDRYDILEEIGTGAFG 8001

Human  1487 QVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIV 1551
            .|.|..|:.|..::|.||.....:.||:.||:||.|||.|||.||:...||||:...::::||.:
  Fly  8002 VVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQKLINLHDAFEDDDEMILILEFL 8066

Human  1552 SGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDF 1616
            |||||||||..|.:.:||.|.|.|||||.||:.::|:|.|:|||:|||||||..::.|.:|||||
  Fly  8067 SGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDF 8131

Human  1617 GLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLA 1681
            |||.||:....:|:..||.||.|||::|.||:|:.||||:.||:.|:|:||||||.||||.:||.
  Fly  8132 GLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLK 8196

Human  1682 NVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRM 1746
            ||.:..||||.|:|..||::|||||..||.::.:.|:...:||.||||..|...|: :::::||.
  Fly  8197 NVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRMTAHECLLHPWLTGDHSAMK-QEINRDRY 8260

Human  1747 KKY--MARRKWQKTGNAVRAIGRLSSMAMISGLSGRK---------------------------- 1781
            ..|  ..|||::.....:..|||||..:.:..|...|                            
  Fly  8261 LAYREKLRRKYEDFERFLLPIGRLSEYSSLRKLLMEKYKIHDAVFDRRQAAPRFVIRPSSQFCYE 8325

Human  1782 ----------SSTGSPTSP--------------------------LNAEKLE------------- 1797
                      .:..:||..                          :|..||:             
  Fly  8326 GQSVKFYCRCIAIATPTLTWSHNNIELRQSVKFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHY 8390

Human  1798 -SEEDVSQAFLEAVAEEKPHVK------------------------PYFSKTIRDLEVVEGSAAR 1837
             |.|:|....::.:.:|:|..:                        |.|:..:|...:......:
  Fly  8391 GSREEVVFLNVQPLPKEQPRYRTESTPVRRREPLPYTFWQEESETAPSFTFLLRPRVMQARDTCK 8455

Human  1838 FDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEAT 1902
            ..|.:.|.|.|.|.|:||.:.:  |::.......||..::.|.|....|..||:|||.|..|...
  Fly  8456 LLCCLSGKPVPNVRWYKDGREL--SKYEYAMTHSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDE 8518

Human  1903 CTAELIVE----TMEEGE 1916
            ....:|||    |.|:.:
  Fly  8519 TDCVVIVEGEWVTPEQAQ 8536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYLKXP_024309300.1 I-set 43..133 CDD:254352 19/92 (21%)
I-set 171..260 CDD:254352 18/90 (20%)
23ISL 261..422 CDD:318761 31/182 (17%)
I-set 424..514 CDD:254352 22/118 (19%)
I-set 524..610 CDD:254352 36/89 (40%)
I-set 633..722 CDD:254352 23/92 (25%)
I-set 731..819 CDD:254352 18/101 (18%)
I-set 1108..1197 CDD:254352 16/88 (18%)
Ig8_hMLCK_like 1248..1345 CDD:143239 27/96 (28%)
FN3 1341..1433 CDD:238020 36/95 (38%)
STKc_MLCK1 1471..1729 CDD:271093 135/257 (53%)
I-set 1819..1909 CDD:254352 24/89 (27%)
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020 4/24 (17%)
FN3 6754..6840 CDD:238020 21/104 (20%)
I-set 6855..6946 CDD:254352 18/90 (20%)
Ig 6874..6946 CDD:299845 13/71 (18%)
FN3 6950..7042 CDD:238020 16/93 (17%)
FN3 7050..7139 CDD:238020 21/127 (17%)
FN3 7151..7237 CDD:238020 13/86 (15%)
I-set 7254..7334 CDD:254352 32/79 (41%)
Ig 7272..7339 CDD:143165 30/66 (45%)
IG_like 7354..7440 CDD:214653 21/86 (24%)
Ig 7366..7440 CDD:299845 17/74 (23%)
FN3 7444..7531 CDD:238020 23/120 (19%)
FN3 7545..7637 CDD:238020 22/119 (18%)
I-set 7648..7737 CDD:254352 31/205 (15%)
Ig 7665..7734 CDD:143165 21/127 (17%)
Ig 7760..7833 CDD:299845 19/72 (26%)
FN3 7837..7927 CDD:238020 35/90 (39%)
STKc_Twitchin_like 7986..8244 CDD:271016 135/257 (53%)
S_TKc 7989..8244 CDD:214567 134/254 (53%)
Ig 8311..8394 CDD:299845 6/82 (7%)
I-set 8312..8401 CDD:254352 8/88 (9%)
I-set 8437..8525 CDD:254352 24/89 (27%)
Ig 8455..8519 CDD:143165 21/65 (32%)
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 74 1.000 Domainoid score I9222
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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