DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYLK and Dscam1

DIOPT Version :9

Sequence 1:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	1870	Identity:	368/1870 - (19%)
Similarity:	605/1870 - (32%)	Gaps:	625/1870 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   171 PKFATKLGRVVVKE---------GQMGRFSCKITGRPQPQVTWLK------GNVP---------- 210
            |..|.:.|.|.:||         .......||.:|.|.|::.|::      |:||
  Fly    31 PPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGK 95

Human   211 -LQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGL------DSANR 268
             :.|..|.....:      |:|      ..||.||..|..| :.:|.::.::.:      :..::
  Fly    96 LVFPPFRAEDYRQ------EVH------AQVYACLARNQFG-SIISRDVHVRAVVSQHYEEDIHK 147

Human   269 SFVRETKATNSDVRK--------EVTNVIS-----KESKLDSLEAAAKSKNCSS---------PQ 311
            :||..   .||.:.|        :..||||     ||:.....|...|.....|         |:
  Fly   148 AFVIR---GNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPE 209

Human   312 RGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSP 376
            .|                .|...|:...|...:|. |..|...:.:      .||    :|.:||
  Fly   210 DG----------------YKSYQCRTKHRLTGETR-LSATKGRLVI------TEP----VGSVSP 247

Human   377 SGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTV 441
                              :..|.|:|:.::..   |:|..|                      :|
  Fly   248 ------------------QLSGNGNQEHITLT---RVPKMG----------------------SV 269

Human   442 KFRCEVSGIPKPEVAW--FLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQG 504
            ...|.....|.|...|  |:||| .|:|...:.......|..|.:..|...|||.|.|..:|:.|
  Fly   270 TLMCPAQAYPVPFFRWYKFIEGT-TRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVG 333

Human   505 QLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIE-GQDFVLQCSVRGTPVPRITWLLNGQPIQYAR 568
            ..|....|.|       .||..:.:......:: |:..|..|...|.|:..::|:.:|:.|.::.
  Fly   334 GESVETVLTV-------TAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSE 391

Human   569 STCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAP 633
            ..       |.|:....||.|.|.|...|.......||     |.|...:.:           .|
  Fly   392 PV-------LRIESVKKEDKGMYQCFVRNDQESAEASA-----ELKLGGRFD-----------PP 433

Human   634 IFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHS-----LCIQ 693
            :..|...:..:..|..|.:.....|||.||:.|..:|.:|..::.:...|..|.:.     |.|.
  Fly   434 VIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNIT 498

Human   694 EVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDP 758
            .|...|.|.|.|.|.:..|.....|.|.|.    |..  :|.:........|::::::|.:||.|
  Fly   499 SVHANDGGLYKCIAKSKVGVAEHSAKLNVY----GLP--YIRQMEKKAIVAGETLIVTCPVAGYP 557

Human   759 FPTVHWLRDGKALCKDTGHFEVLQNEDVF---TLVLKKVQPWHAGQ--YEILLKNRVGECSCQVS 818
            ..::.|.||.:||       .:.:.:.||   ||:::.|:. ::.|  |..:.||:.| .|.:.|
  Fly   558 IDSIVWERDNRAL-------PINRKQKVFPNGTLIIENVER-NSDQATYTCVAKNQEG-YSARGS 613

Human   819 LMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVL 883
            |.:|   ...||: ..|.:.|||..     .|...|.:..::.|
  Fly   614 LEVQ---VMVLPQ-IVPFAYEDLIN-----MGDSIDLFCQIQKG--------------------- 648

Human   884 KRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTV 948
            .|.::.....|.:......:|                                  :|.|::...:
  Fly   649 DRPIKVHWSFERSAGDYGFDQ----------------------------------VQPQMRTNRI 679

Human   949 SEEERKVH----SPQQVDFRSVLA--KKGTS--KTPVPEKVPPPKPATPDFRSVLGGKKKLPAEN 1005
            ||:...:.    ||......:.:|  |.||:  ...:...|||        |.:|....|..|:.
  Fly   680 SEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPP--------RWILEPTDKAFAQG 736

Human  1006 GSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLK 1070
            ..:..|                     .|..|..||..|.|           |.:|:. |.|
  Fly   737 SDAKVE---------------------CKADGFPKPQVTWK-----------KAVGDT-PGE--- 765

Human  1071 SASKEELKKDVKNDVNCKRGHAGT--TDN-EKRSE---------------------SQGTAPAFK 1111
                   .||:|...|. |...||  .|| :|.:|                     |....|.|.
  Fly   766 -------YKDLKKSDNI-RVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFT 822

Human  1112 QKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLK-------TTKFIILSQEGSLCSVSIEK 1169
            :||::.....|:..:|||:...:.|..|:|.:|...|.       |.:..||| .|.:.|:||::
  Fly   823 EKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILS-TGVMSSLSIKR 886

Human  1170 ALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT--ESDATV 1232
            ....|..|:.|||.|..|..:.|..:.|.:.|                 .:|..|..  :|..:|
  Fly   887 TERSDSALFTCVATNAFGSDDASINMIVQEVP-----------------EMPYALKVLDKSGRSV 934

Human  1233 KKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVE 1297
            :...|......:.:...||:|   ::.||                  :|.:..:.|... |....
  Fly   935 QLSWAQPYDGNSPLDRYIIEF---KRSRA------------------SWSEIDRVIVPG-HTTEA 977

Human  1298 NSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTP---CASDIRSSSLT 1359
            ..:..|..|....|        ::.||.:|:.|:...:|::...:.|:|.|   ....:..:::.
  Fly   978 QVQKLSPATTYNIR--------IVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMR 1034

Human  1360 LSW--------------YGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEY 1410
            ::|              |...|...:...||..|..:...:..||      .:..:|:|....:|
  Fly  1035 VTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKE------HNLELQNLRVYTQY 1093

Human  1411 KFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYD 1475
            ...::|.|..|....|:|.:..|....|.:|..:.               ..|..|.|.:
  Fly  1094 SVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDT---------------ACTTLTSQTI----- 1138

Human  1476 IEERLGSGKFGQVFRLVEK-----KTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCV 1535
                    :.|.|...:|.     ||.||......:.|. :.|.:.::..|....||
  Fly  1139 --------RVGWVSPPLESANGVIKTYKVVYAPSDEWYD-ETKRHYKKTASSDTVLH-------- 1186

Human  1536 DAFEEKANIVM-VLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPE 1599
             ..::..|..| ||...:||                          :||..:.    :|...:|:
  Fly  1187 -GLKKYTNYTMQVLATTAGG--------------------------DGVRSVP----IHCQTEPD 1220

Human  1600 NIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYIL 1664
                |.:..|.:|.:..|      ||..| |.:..|.         :|.|..|.     ...|..
  Fly  1221 ----VPEAPTDVKALVMG------NAAIL-VSWRPPA---------QPNGIITQ-----YTVYSK 1260

Human  1665 VSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL 1729
            ..|.       :.||.                                        ||.:.|..:
  Fly  1261 AEGA-------ETETK----------------------------------------TQKVPHYQM 1278

Human  1730 MKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAE 1794
                 :.||.:|.|::..::     | .|.:.....|:.|           ||....|:..:.|
  Fly  1279 -----SFEATELEKNKPYEF-----W-VTASTTIGEGQQS-----------KSIVAMPSDQVPA- 1320

Human  1795 KLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSI 1859
            |:.|.:|.                  |:.|.::       .|:..|...|.|.||:.|  ..:.:
  Fly  1321 KIASFDDT------------------FTATFKE-------DAKMPCLAVGAPQPEITW--KIKGV 1358

Human  1860 RESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1909
            ..|.:.::....||  ||:|..|...|...|:|.|.||:.:.:.|.:|||
  Fly  1359 EFSANDRMRVLPDG--SLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIV 1406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352	26/114 (23%)
		23ISL	261..422	CDD:318761	33/188 (18%)
		I-set	424..514	CDD:254352	23/91 (25%)
		I-set	524..610	CDD:254352	19/86 (22%)
		I-set	633..722	CDD:254352	25/93 (27%)
		I-set	731..819	CDD:254352	22/92 (24%)
		I-set	1108..1197	CDD:254352	29/95 (31%)
		Ig8_hMLCK_like	1248..1345	CDD:143239	16/96 (17%)
		FN3	1341..1433	CDD:238020	19/108 (18%)
		STKc_MLCK1	1471..1729	CDD:271093	41/263 (16%)
		I-set	1819..1909	CDD:254352	24/89 (27%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	24/104 (23%)
		IG	57..133	CDD:214652	20/88 (23%)
		IG_like	267..343	CDD:214653	24/98 (24%)
		Ig	269..340	CDD:143165	22/71 (31%)
		IG_like	353..425	CDD:214653	19/83 (23%)
		IGc2	361..413	CDD:197706	15/58 (26%)
		I-set	433..527	CDD:254352	25/93 (27%)
		IGc2	446..517	CDD:197706	20/70 (29%)
		I-set	533..618	CDD:254352	25/96 (26%)
		IGc2	544..607	CDD:197706	19/70 (27%)
		Ig	641..714	CDD:143165	14/127 (11%)
		IGc2	735..804	CDD:197706	22/112 (20%)
		I-set	819..914	CDD:254352	29/95 (31%)
		Ig	833..921	CDD:299845	27/105 (26%)
		FN3	918..1011	CDD:238020	22/139 (16%)
		FN3	1018..1116	CDD:238020	18/103 (17%)
		FN3	1124..1217	CDD:238020	25/160 (16%)
		FN3	1222..1312	CDD:238020	28/179 (16%)
		Ig	1339..1406	CDD:299845	21/70 (30%)
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910