DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYLK and zormin

DIOPT Version :9

Sequence 1:XP_024309300.1 Gene:MYLK / 4638 HGNCID:7590 Length:1924 Species:Homo sapiens
Sequence 2:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster


Alignment Length:2516 Identity:475/2516 - (18%)
Similarity:788/2516 - (31%) Gaps:885/2516 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    42 APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRF--LLDCGIRGTFSLVIH 104
            :|.|..|.::...:||....||..|.|.|||.|.|.::|..|.:...:  ..|   :|...|||.
  Fly  1389 SPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFD---KGICRLVIE 1450

Human   105 AVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGEC 169
            .....|..:::|.|:|..|.......|:|                   |.:|..|:.       .
  Fly  1451 ETFAADSARFSCRASNLVGTCDTNATLSV-------------------RENAAEVQL-------V 1489

Human   170 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVN 234
            ||:....|......||...:|:|.:.|.|.|.|.|.|.:..:..|....:|..||...|:...|.
  Fly  1490 PPRILRFLQSGKATEGSSFQFACVVAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVF 1554

Human   235 QDDVGVYTCLVVNGSGKASMSAELSIQGLDSAN-RSFVRETKATNSDVRKEVTNVISKESKLDSL 298
            .:|..||||...|.:|....||.|.::.|:... .||           :..::|.:::..:...|
  Fly  1555 LEDDAVYTCSASNPAGIEHCSASLIVEPLEPTELPSF-----------KVPLSNAMARVGQKIKL 1608

Human   299 EAAAKSKNCSSPQRGGSPP----WAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQA 359
            ||..          ||.|.    |..|.:|..||:||.|                  ...:||  
  Fly  1609 EAIV----------GGIPRPEVYWLHNGKPFQPRDSKYE------------------YGRVTL-- 1643

Human   360 ARVQPE--PRAPGLGVLSP---SGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQR 419
              :.|:  |...|..|||.   :||                  ...|.:|:.|.   |:|.|...
  Fly  1644 --IIPQAYPNDAGSYVLSAKNLAGE------------------AYTSCNVIVKG---RLPNETSD 1685

Human   420 DSAFPKFES-KP------QSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDA 477
            .......|. ||      :...:.|.:.|:..|.:.|.|:|||.|:....|| ::...:::....
  Fly  1686 SEMASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPV-KESADVQLLFQG 1749

Human   478 GSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVA---------------PSFS 527
            ....|.:.:....|:|.|...|.|:.|:.|.|..|:|..|...|.|               |.|.
  Fly  1750 DRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFE 1814

Human   528 SVLKDCAVIEGQDFVL------------------------------------------------- 543
            .:|.|....||:..||                                                 
  Fly  1815 RLLSDVLADEGEQVVLEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSELGVFKLILNNVSGDD 1879

Human   544 ----------------------------------------------------------------- 543
                                                                             
  Fly  1880 KGVYTVKVTNPAGDAKCFSHLIVKSVNAPENRRSSQSSVEIIERHQCPEFKELFSDKQGEIDEVI 1944

Human   544 --QCSVRGTPVPRITWLLNGQPI---QYARSTCEAGVAE-LHIQDALPEDHGTYTCLAENALGQV 602
              :|.|:|.|.|::.|..|.||:   .:..||  :|..: |.||....:..|..:|:|||..|:.
  Fly  1945 KFECIVKGKPTPKVHWFFNDQPVHGHNFLVST--SGERQVLTIQKLTHDAVGKISCVAENEAGKA 2007

Human   603 SCSAWVTV-----------------HEKKSSR--------------------------------- 617
            :|.|::.:                 |..:|||                                 
  Fly  2008 TCVAFLNIRGSGLPASSDVQTVSQEHNTESSRVTIKKQTFTTTSTSQVNSYEGNAPQTEVHHSSA 2072

Human   618 ---------------------------------------------------KSEYLLPVAPS--- 628
                                                               :|...:|.:|:   
  Fly  2073 HIDQSLKQLGQQRPEIVESHHYQELHKSKEMSSPTVQQKSFSFIQSSGANGQSAVAIPDSPTRLR 2137

Human   629 KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQ 693
            :..||.|...||...|..|:.|:|.....|.|.||:....||.::.|........:..:.::.::
  Fly  2138 REIAPRFTTPLSGKIVDQGADVSMEAIYDGFPSPEIKVEKNGGQLFEDAHTRISNKCNRVTIELK 2202

Human   694 EVFPEDTGTYTCEAWNSAGEVRTQAVLTVQE---PHDGTQPWFISKPRSVTASLGQSVLISCAIA 755
            :|...|.|.|...|.|:.|:..:.|.|.|::   |     |.|..:.::..:..|:.:.:...:.
  Fly  2203 QVGVGDAGRYAVTASNTVGQSTSTADLVVKKTIFP-----PVFGRRLQAQVSKKGEKLTMEVEVT 2262

Human   756 GDPFPTVHWLRDGKALCKDTGHFE--VLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVS 818
            |.|.|||.||:|.|.| ||.|..|  :|...:.:.|:::|.|...:|:|.:...|..||......
  Fly  2263 GLPEPTVTWLKDDKPL-KDAGISEHRLLAQGNSYRLIIEKAQTTDSGKYMVRATNAGGEAKSIAD 2326

Human   819 LMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVL 883
            ..:...|         |...:::....|...|          |..||           .:.:..:
  Fly  2327 CAILEPS---------PERLQEVVKTIVYETG----------PVAPA-----------SEFKTEV 2361

Human   884 KRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANL----QRQVK 944
            :::::..:: :::.:..:.|.....||.|...| |.::|.........:::.::|.    :...:
  Fly  2362 QKQIQNSEN-QQSYQNSQTEVTSANDLHGLSES-KVITEHRCTTEATMRLEHKSNYLDLPELTTR 2424

Human   945 PK---------------TVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSV 994
            ||               |||.::..:..|      ::.....|:.|.||..| ||||.||...:.
  Fly  2425 PKTPTTNDTITITTNTATVSMDQPDLTQP------TITNTTTTNTTKVPPPV-PPKPCTPVVATT 2482

Human   995 LGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSG--PLKPVGNAKPAETLKPMGNAKPAETL 1057
            .|.:::.|       .:||.:...|.|:..|....|.  ..|.:......:...|:       |.
  Fly  2483 FGQQQQQP-------PQTLTSTRYEQSEHKSTTSSSSFDYFKKIDEETIIQRPNPL-------TF 2533

Human  1058 KPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGT---TDNEKRSE----------------- 1102
            ||:     |..::....:.|.::::: :|...|.|..   :...:|||                 
  Fly  2534 KPL-----DTVVRQPQAQSLAEELRS-LNLIPGDAPEFCYSPKTERSEPKIPLITEKIKILSEVQ 2592

Human  1103 -----SQGTAPAFKQKL------------QDVHVAEGKKLLLQCQVSSDP-----------PA-- 1137
                 .||..|.|...|            ::|.|..|:.::....|.:.|           |:  
  Fly  2593 PKEPPPQGGVPVFPPPLGLQTVQHESTTTKEVKVEYGQPIVRPAAVLATPAQQNPRSPSPKPSAE 2657

Human  1138 ----TIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRG--LYKCVAKN-DAGQAECSCQV 1195
                :.:||..|.|..|:.....|::..:..::......|...  |...:||: ....|..:..|
  Fly  2658 GVAMSRLWTPTGVTGYTSDVEQKSEKTVISKLATPTPTKELNAPFLVNQIAKSIPPTTAPVTHLV 2722

Human  1196 TVDDAPAS--ENTKAPEMKSRR-------------------PKSSLP---PVLGTESDATVKKKP 1236
            .|:..|.:  |...||:::..|                   |...||   |.|...:.|.|:.||
  Fly  2723 NVELEPGTPPEICFAPKVEETRRRSLVETMEQKLEQNLIQGPSKVLPHSVPTLTPNTAAPVQPKP 2787

Human  1237 APKT---PPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQ--------- 1289
            ...|   ||...:|.::..:..|.:   .:..:..|..:..:|      ..|||.|         
  Fly  2788 LGNTTYRPPPPVLPTRLGVYESDYE---SDRYKYSGSESDVEP------GIRKQPQLTTMETSFK 2843

Human  1290 ----------ESEHMKVENS--ENGSKLTILAARQEHCGCYTLLVENKLGSRQ----AQVNLTVV 1338
                      .|.:.|.|:|  |..|..|:..|.|         ::.:....|    |.:..|..
  Fly  2844 SSGYTADTEEHSSYRKSESSFYETKSSSTMGGAPQ---------LQTQFPKLQPEPPAPIYFTAK 2899

Human  1339 DKPD-PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKEL----------- 1391
            .:|. ||...|..|::.|....    |..|...|...:||..:..|::.:..|.           
  Fly  2900 PQPQVPPQVPPSQSNVSSQEAK----GYKYTSSSMTSNYSHNMQSSSSSSHHETKFSSTSAPPPV 2960

Human  1392 --------ATCRSTSFNVQDLLPDHEYKFR-----------VRAINVYGTSEPSQESELTTVGEK 1437
                    |..::.:....|...:.:.:||           ::...|.....|:..:.:.|.|.|
  Fly  2961 VTYPSPIPAQRKTPAAEFSDYSSEIDERFRSVSRANESDAEIKGYRVVFPPTPTPRTNIATNGHK 3025

Human  1438 ------PEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQ-------VF 1489
                  ...|. |.|.:..|...|:.:..:..|..|.|.      |......||.|       ||
  Fly  3026 SPVVVITPSPM-EFEPTPQDYARPKFEPISKEIRHEIKT------ETSSKQSKFMQNQQQNQPVF 3083

Human  1490 RLVEKKTRKVWAGKFFKA------------------YS------------AKEKENIRQ-----E 1519
            :      .|..|.||..|                  |:            |.|.:|:.|     |
  Fly  3084 K------PKPVAAKFIAATQQQQQKQPQATSRPTMYYNAVAGAPMHVAKVATETKNVMQMHESTE 3142

Human  1520 IS--IMNCLHHPKLVQCVDAFEEKANIVMVLE--------------------------IVSGGEL 1556
            .|  ::| :...|.:...|:.:|:.: ..:||                          .|.|   
  Fly  3143 SSQRVVN-MQQTKRIIHFDSPQEQRD-QQILEPFPYSPATSRTPSRQSHLPPPATPTKFVPG--- 3202

Human  1557 FERIIDEDFE------------------LTE------------RECI---KYMRQIS-----EGV 1583
              ...:.|:|                  :|:            |.|.   .|.|.:|     .|.
  Fly  3203 --EFRESDYESEIDGARIQPLWSPYGDGMTKGFRRVAPPQGAGRSCSLPRTYERVLSPMEFDRGP 3265

Human  1584 EYIHKQGIVHLDL-----------------------------------KPENIMCVNKTGTRIKL 1613
            |...|   :|:|:                                   :.:::..:::.||..:.
  Fly  3266 EMPSK---IHVDINTLRKEQRGGSTVTTQNRTQSLNRNTTMRQQQQQQQQQSMDQIDRAGTLPRY 3327

Human  1614 IDFGLARRLENAG---SLKVLFGTPEFV---------------------AP-EVINYEPIGYATD 1653
            ....|.::.||.|   ....|..:.:||                     || |..:.:|..:..:
  Fly  3328 GYSSLQQQAENQGRRMGSTFLQKSHQFVDDVSREIRSSASNGIRPGFKRAPSEGSSQQPQAFRDE 3392

Human  1654 --MWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKN 1716
              :...|..|....:||..|               .:||..|.......:...|:|:        
  Fly  3393 SRVSQYGTKCVDPNTGLIYF---------------KYDFGYEFGILFPGEGHKFVSS-------- 3434

Human  1717 RLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV--------RAIGRLSSMAM 1773
                      .|....:.|..||.:...|...|..:   ...||.:        .|.|..|...:
  Fly  3435 ----------QWNSSGSSNSNAKPIQNGRHSPYPLK---LPPGNELVIPVQHERSAQGYSSDNEV 3486

Human  1774 ISGLSGRKSSTGSPTSP--LNAEKLES-----EEDVSQAFLEAVAEEKP---------------- 1815
            ......|..||..|.:|  :|:.|..|     ..|:....|.|.|...|                
  Fly  3487 QRRSQTRNWSTTKPMAPRTINSHKRYSLPSGHSLDIHLDRLHAQAPRLPPDQMIRTVPELPNTEP 3551

Human  1816 ---HV--------KPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDY 1869
               |:        :|.|...::|:.|..|..|||:|.::.:|.|:|.|..:...:.......|:|
  Fly  3552 VNAHLSRDELAQRQPLFITPLKDIAVGVGGTARFECIVQAHPQPQVNWTHNGGLLESGSRHCIEY 3616

Human  1870 DEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEG 1915
             .:|.|.|.:.....||:..|.|.|:|.||.||.:..|.|.:...|
  Fly  3617 -RNGVCRLTLPQAYPDDNGSYACTAINPLGAATTSGNLTVSSTNRG 3661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYLKXP_024309300.1 I-set 43..133 CDD:254352 27/91 (30%)
I-set 171..260 CDD:254352 28/88 (32%)
23ISL 261..422 CDD:318761 34/170 (20%)
I-set 424..514 CDD:254352 24/96 (25%)
I-set 524..610 CDD:254352 31/205 (15%)
I-set 633..722 CDD:254352 24/88 (27%)
I-set 731..819 CDD:254352 26/89 (29%)
I-set 1108..1197 CDD:254352 21/120 (18%)
Ig8_hMLCK_like 1248..1345 CDD:143239 21/122 (17%)
FN3 1341..1433 CDD:238020 19/122 (16%)
STKc_MLCK1 1471..1729 CDD:271093 62/427 (15%)
I-set 1819..1909 CDD:254352 29/89 (33%)
zorminNP_001261317.1 SPEC 126..332 CDD:238103
SPEC <504..641 CDD:295325
COG1340 960..1298 CDD:224259
RILP-like <1190..1315 CDD:304877
MAP7 1233..1365 CDD:283355
I-set 1390..1479 CDD:254352 27/91 (30%)
IGc2 1403..1469 CDD:197706 22/68 (32%)
I-set 1491..1580 CDD:254352 28/88 (32%)
IGc2 1504..1570 CDD:197706 22/65 (34%)
I-set 1589..1675 CDD:254352 29/146 (20%)
Ig 1605..1675 CDD:299845 26/119 (22%)
I-set 1702..1786 CDD:254352 21/84 (25%)
Ig 1713..1786 CDD:299845 20/73 (27%)
I-set 1811..1902 CDD:254352 8/90 (9%)
Ig 1828..1892 CDD:143165 2/63 (3%)
I-set 1927..2015 CDD:254352 23/89 (26%)
IGc2 1940..2005 CDD:197706 20/66 (30%)
I-set 2142..2231 CDD:254352 24/88 (27%)
Ig 2158..2231 CDD:299845 18/72 (25%)
I-set 2238..2325 CDD:254352 26/87 (30%)
Ig 2254..2324 CDD:299845 23/70 (33%)
I-set 3566..3655 CDD:254352 29/89 (33%)
Ig 3583..3650 CDD:143165 23/67 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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