DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYLK and cmk1

DIOPT Version :9

Sequence 1:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens
Sequence 2:	NP_593464.1	Gene:	cmk1 / 2542442	PomBaseID:	SPACUNK12.02c	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	308	Identity:	104/308 - (33%)
Similarity:	165/308 - (53%)	Gaps:	9/308 - (2%)

- Green bases have known domain annotations that are detailed below.

Human  1463 TINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFF-KAYSAKEKENIRQEISIMN-- 1524
            |::.:|.:...|.:...||.|.:..|...|..:|.|::|.|.. |....|:::.::.||:|:.
pombe    20 TVDQKQLLPCKYRVGRVLGGGTYATVREAVHIETNKMYAAKIMNKKMMEKKQDFVKNEIAILKRV 84

Human  1525 CLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQ 1589
            ...||.::..||.||...|:.::.|:.:|||||:||..:. ...|.:....||..:..|:|:|..
pombe    85 SYEHPNILHLVDFFETVNNLYLITELATGGELFDRICAKG-SFYEADAAALMRTTTSAVKYLHDN 148

Human  1590 GIVHLDLKPENIMCVNK-TGTRIKLIDFGLARRLENAG--SLKVLFGTPEFVAPEVINYEPIGYA 1651
            ||||.||||||::..:| ..:.:.:.||||:...|::.  .|....||||::||||......|..
pombe   149 GIVHRDLKPENLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRRTGYGKP 213

Human  1652 TDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKN 1716
            .|||:||||.|.|:||.:||...:..|.:..:.:..:.|:|..:..||:.|||||...|:.|...
pombe   214 VDMWAIGVITYFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDFIKKCLENDPSK 278

Human  1717 RLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRA 1764
            ||.....|:||:|.:  |......|..:..:.:.||:.::...|||||
pombe   279 RLTAADALKHPFLSE--KRPATSNLLPNVRENFNARKTFRTAYNAVRA 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352
		Ig8_hMLCK_like	1248..1345	CDD:143239
		FN3	1341..1433	CDD:238020
		STKc_MLCK1	1471..1729	CDD:271093	92/263 (35%)
		I-set	1819..1909	CDD:254352
cmk1	NP_593464.1	STKc_CAMK	30..290	CDD:270687	91/260 (35%)
cmk1	NP_593464.1	S_TKc	31..291	CDD:214567	92/260 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910