DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYLK and cmk-1

DIOPT Version :9

Sequence 1:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens
Sequence 2:	NP_500139.1	Gene:	cmk-1 / 176989	WormBaseID:	WBGene00000553	Length:	348	Species:	Caenorhabditis elegans

Alignment Length:	336	Identity:	125/336 - (37%)
Similarity:	191/336 - (56%)	Gaps:	29/336 - (8%)

- Green bases have known domain annotations that are detailed below.

Human  1470 VSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFF-------KAYSAKEKENIRQEISIMNCLH 1527
            :.:.||..:.||:|.|.:|| |.|.|:.   ||:.:       ||...|| |::..||.::..|.
Worm    18 IREKYDFRDVLGTGAFSKVF-LAESKSD---AGQMYAVKCIDKKALKGKE-ESLENEIKVLRKLR 77

Human  1528 HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIV 1592
            |..:||..|.::||..:.:|:|:|:|||||:||:.:. ..||::....:||:.|.|.::|..|:|
Worm    78 HNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKG-SYTEQDASNLIRQVLEAVGFMHDNGVV 141

Human  1593 HLDLKPENIMCVNK-TGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWS 1656
            |.||||||::..|: ..::|.:.||||: :.|::|.:....|||.:|||||:..:|.|.|.|:||
Worm   142 HRDLKPENLLYYNQDEDSKIMISDFGLS-KTEDSGVMATACGTPGYVAPEVLQQKPYGKAVDVWS 205

Human  1657 IGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCT 1721
            ||||.|||:.|..||..::|....|.:....::||...:|:|||.|||||::|:..|.:.|..|.
Worm   206 IGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQ 270

Human  1722 QCLQHPWLMKDTKNMEAKKLSKD-------RMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSG 1779
            ..|.|||:..:|      ..:.|       .:||.:|:|.|:|..||..||.:| .|..:|..|.
Worm   271 DALSHPWISGNT------AYTHDIHGTVAVHLKKSLAKRNWKKAYNAAAAIRQL-QMLRLSSNSN 328

Human  1780 RKSSTGSPTSP 1790
            |.....|...|
Worm   329 RLQKQASQQQP 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352
		Ig8_hMLCK_like	1248..1345	CDD:143239
		FN3	1341..1433	CDD:238020
		STKc_MLCK1	1471..1729	CDD:271093	105/265 (40%)
		I-set	1819..1909	CDD:254352
cmk-1	NP_500139.1	STKc_CaMKI	18..277	CDD:270985	104/265 (39%)
cmk-1	NP_500139.1	S_TKc	22..278	CDD:214567	105/262 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920