|
Human 12 GDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTW 76
|:|...:..|: |::.|.:| |....|:.|.::..::||.....:..:.|.|.|:|.|
Worm 5049 GEVYSGSVVHV-KSAKSSEP--------TSGANFLSPLKDTEVEEGDMLTLQCTIAGEPFPEVIW 5104
Human 77 HRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQL 141
.::|..:....|..:...:.||.:|.|.:..:.|.|:|...|.|.:|:.....::|| .:|.
Worm 5105 EKDGVVLQKDDRITMRVALDGTATLRIRSAKKSDIGQYRVTAKNEAGSATSDCKVTV----TEQG 5165
Human 142 GQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLK 206
.|| || |||...|.......|....|:.|:.|.|:|.:.|..
Worm 5166 EQP--SK----------------------PKFVIPLKTGAALPGDKKEFNVKVRGLPKPTLQWFL 5206
Human 207 GNVPLQPSARVSVSE-KNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGL--DSANR 268
..:|::...|:::.: .:|...|.|..|.::|.|...|:..|.:|......|.. ||. |..:|
Worm 5207 NGIPIKFDDRITLDDMADGNYCLTIRDVREEDFGTLKCIAKNENGTDETVCEFQ-QGAGHDDGSR 5270
Human 269 SFVRETKATNS---DVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRES 330
..:|.....|. |.|..|.:.:..|..:|:...|
Worm 5271 DDLRYPPRFNVPLWDRRIPVGDPMFIECHVDANPTA----------------------------- 5306
Human 331 KLESCKDSPR---TAPQTPVLQKTSSSITLQAARVQPEP-RAPGLGV-----LSPSGEERKRPAP 386
::|..||..: || .|.:...... |.|::..| ....:|| ::..|:...:
Worm 5307 EVEWFKDGKKIEHTA-HTEIRNTVDG-----ACRIKIIPFEESDIGVYMCVAVNELGQAETQ--- 5362
Human 387 PRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIP 451
||:.. ::: ..:..|.:|:.| ||.....:.:.|...|.::..|:|..||
Worm 5363 ---ATYQV--------EIL-----EHVEEEKRREYA-PKINPPLEDKTVNGGQPIRLSCKVDAIP 5410
Human 452 KPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQL--SCSWTLQV 514
:..|.|:.:|.|:|....:...||:.|:..|.:..:...|.|.|.|.|:||.|.: |||..::|
Worm 5411 RASVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRCVATNAHGTINTSCSVNVKV 5475
Human 515 ERLAVMEVA--PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYA-RSTCEA--- 573
.:..|.:.. |.|:..|.|.....|..|.|:|:|.|.|.|.|.|..|||.::.. |:..|.
Worm 5476 PKQEVKKEGEEPFFTKGLVDLWADRGDSFTLKCAVTGDPFPEIKWYRNGQLLRNGPRTVIETSPD 5540
Human 574 GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP-----TAP 633
|...|.:.::...|.|.|.|.||||.|:....| |.|.:.:..|:| || ..|
Worm 5541 GSCSLTVNESTMSDEGIYRCEAENAHGKAKTQA--TAHVQMALGKTE--------KPKMDEGKPP 5595
Human 634 IFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQ--HSLCIQEVF 696
.|:..|||:.|..|:.:.:..:|:|.|.|.|.|..:|..:.|...|.:....:: :.|.|:...
Worm 5596 KFILELSDMSVSLGNVIDLECKVTGLPNPSVKWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNAT 5660
Human 697 PEDTGTYTCEAWNSAGEVRTQA-----------VLTVQEPHDGTQPWFISKPRSVTASLGQSVLI 750
..|.|||.|.|.|..|...|:: |:|..:| |.|..|...|..:.||.:.:
Worm 5661 VHDEGTYRCVATNENGSATTKSFVRMDDGLGSGVVTASQP-----PRFTLKMGDVRTTEGQPLKL 5720
Human 751 SCAIAGDPFPTVHWLRDGKALCKDTGHFEV-LQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECS 814
.|.:...|.|.:.|.:|| |:...:...:: |..:.|.||::........|.|.::..|..|...
Worm 5721 ECKVDASPLPEMVWYKDG-AIVTPSDRIQISLSPDGVATLLIPSCVYDDDGIYRVIATNPSGTAQ 5784
Human 815 CQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDV 879
.: ..::.:.||| |.|.
Worm 5785 DK-----GTATVKKLPR-----------------DSGA--------------------------- 5800
Human 880 RGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVK 944
:|..: ||:.....:.|.:...:...|| |:..||...:....
Worm 5801 ----RRSAD-------------------RDVFDANKAPKLMEPLENIRIP-EKQSFRLRCKFSGD 5841
Human 945 PKTV----SEEER--------KVHSPQQV--------------DFRSVLAKK-GTSKTPVPEKVP 982
||.. .:.|| .:.||..| .:|.|.... |:::|
Worm 5842 PKPTIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQDAGGYRCVAENTYGSART------- 5899
Human 983 PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLK- 1046
:.|...:.|.:| |.:..||..| .||...:.||: :..|||.:::.
Worm 5900 -----SCDVNVIRGDRK--PRDIDSSIRE---GKAPGFTTPLT----------IRRAKPGDSVTF 5944
Human 1047 ---PMGNAKPA-ETLKPMGNAKPDENLK-SASKEELKKDVKNDV--------NC----KRGHAGT 1094
|.||..|: :.||.......||.:| .|:.:..::.:.:|| .| :.|.|.|
Worm 5945 ECLPFGNPFPSIKWLKDGLELFSDEKIKMEAAADGTQRLILSDVTFLSEGYFRCVATNEHGTAST 6009
Human 1095 TDN---------------EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLN 1144
... |...|.:...|..::.|.::.:.||..:.:....:..|..|:.|..:
Worm 6010 KAELVIEGDRTIGSRPLPEVNGEPEECKPRIRRGLYNMSIHEGNVVEMIVCATGIPTPTVKWYKD 6074
Human 1145 GKTL----KTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTV----DDAP 1201
|:.: ...|.:|.:.|..:..:.|..|.|:|.|.|...|.|..|.|:....:.: ..|.
Worm 6075 GQEIVGDGPDGKRVIFTDERGIHHLVIVNASPDDEGEYSLEATNKLGSAKTEGSLNIIRPRHIAD 6139
Human 1202 ASENTKAP-------EMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKV 1259
|.|....| ::|::...:.:|.:. |..|...|||:
Worm 6140 ADERGGMPFPPGFVRQLKNKHVFNHMPTIF----DCLVVGHPAPE-------------------- 6180
Human 1260 RAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGS-KLTILAARQEHCGCYTLLVE 1323
|| |....|:|.....:|:::...|| .|.||....|..|.|....:
Worm 6181 -----VE--------------WFHNGKKIVPGGRIKIQSCGGGSHALIILDTTLEDAGEYVATAK 6226
Human 1324 NKLGSRQAQV-------------------------------NLTVVDKPDPPAGTPCASDIRSSS 1357
|..||..:.. .|.....|.||...|...::....
Worm 6227 NSHGSASSSAVLDVTVPFLDSIKFNGEIDVTPYLTEEYGFKKLNTASLPTPPDRGPFIKEVTGHY 6291
Human 1358 LTLSWYGSSYDGGSAVQ-SYSIEIWDSANKTWKEL------ATCRSTSFNVQDLLPDHEYKFRVR 1415
|||||..:........| :|.|||.:...|.|..| ..|: |::|.....|:||||
Worm 6292 LTLSWIPTKRAPPRYPQVTYVIEIRELPEKQWSLLEYNIPEPVCK-----VRNLELGKSYQFRVR 6351
Human 1416 AINVYGTSEPSQESELTTVGEKPE--------------EPKDE---------------------- 1444
|.|:||.|:||..|..:.:...|: :|..|
Worm 6352 AENIYGISDPSPASPPSRLMAPPQPVFDRRTNKVIPLLDPYAEKALDMRYSEQYACAPWFSPGVV 6416
Human 1445 ----------------------------------------------------------------- 1444
Worm 6417 EKRYCAENDTLTIVLNVSGFPDPDIKWKFRGWDIDTSSPTSKCKVYTYGGSETTLAITGFSKENV 6481
Human 1445 --------------------------------------------VEVSDDDEKEPEVDYR----- 1460
::|..|.|..||:.:.
Worm 6482 GQYQCFAKNDYGDAQQNIMVDLATRPNFIQPLVNKTFSSAQPMRMDVRVDGEPFPELKWMKEWRP 6546
Human 1461 -----------------------------------------------TVTINTE----------- 1467
|||:..|
Worm 6547 IVESSRIKFVQDGPYLCSLIINDPMWRDSGIYSCVAVNDAGQATTSCTVTVEAEGDYNDVELPRR 6611
Human 1468 ------QKVSDFYDI---EERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIM 1523
::|.:.|:| :|:|.:. |..||:.||.| |:.|.|......:.:.:.:.|.
Worm 6612 RVTIESRRVRELYEISEKDEKLAAE--GAPFRVKEKAT-----GREFLAQLRPIDDALMRHVDIH 6669
Human 1524 NCLHHPKLVQCVDAF-EEKANIVMVLEIVSGGELFERIIDEDFELTE-----RE-CIK-YMRQIS 1580
|.|.||.:||..... :||..:|:.....|..:....:.....|:.| || |:: ::||:.
Worm 6670 NSLDHPGIVQMHRVLRDEKLALVVFDNANSTIDGLSSLAHPGVEIAEPKGVNRETCVRVFVRQLL 6734
Human 1581 EGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLEN---AGSLKVLFGTPEFVAPEV 1642
..::::|...|.||||:||.|:..: .::||.|||.||||.. .|.:| |:||||:||:
Worm 6735 LALKHMHDLRIAHLDLRPETILLQD---DKLKLADFGQARRLLRGLITGEIK---GSPEFVSPEI 6793
Human 1643 INYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFIS 1707
:...|:..||||||.||:.|:|::|||||.|||||||||||.|. .||.......|.||.||:.
Worm 6794 VRSYPLTLATDMWSTGVLTYVLLTGLSPFHGDNDNETLANVDSC--QFDSSPLGNFSYDAGDFVK 6856
Human 1708 NLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMA 1772
.||.:...:||...:.|.|||: :.:.::.:.||.|.::::..:.||.:....|:.......:.
Worm 6857 KLLTEIPVSRLTVDEALDHPWI--NDEKLKTEPLSADTLREFKYQHKWLERRVFVQQTPSEQILE 6919
Human 1773 MISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDL--------E 1829
.|.|.:..::...:|.:|......|..: :|....::.|....|..:..::. :
Worm 6920 AILGPATAQAQQNAPVAPEGRRPAEIYD-----YLRIQPKKPPPTVEYVPQPRKEHPPFIDEFGQ 6979
Human 1830 VVEGSAARFDCKIEGY-------------PDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISD 1881
:::|.| || :.||. |.|: :.:|:..:||..:......|....|..|
Worm 6980 LIDGDA--FD-RPEGTGFEGPHRQPPQIPPQPQ----RPNQAAHDSRRHEQQPQHQGQPQRIPVD 7037
Human 1882 VCGDD--DAKY 1890
..|.. |.:|
Worm 7038 QYGRPLVDPRY 7048
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