Protein Alignment l(2)dtl and Dtl

DIOPT Version :10

• Sequence 1: NP_524871.1
• Gene: l(2)dtl / 46326
• FlyBaseID: FBgn0013548
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_084042.1
• Gene: Dtl / 76843
• MGIID: 1924093
• Length: 729
• Species: Mus musculus
• Alignment Length: 784
• Identity: 231/784 - (29%)
• Similarity: 340/784 - (43%)
• Gaps: 198/784 - (25%)

  Fly    49 PEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQC------HFNAVFDL 107
            |.|| |...|.......||||:|||:|.:.|.:|        |.......|      |:||||||
Mouse    49 PVPP-FGCTFCTAPSMEHILAVANEEGFVRLYNT--------ESQTSKKTCFKEWMAHWNAVFDL 104

  Fly   108 EWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILI 172
            .|.||:::.|:|:||.||:.|:|....:.|  :..||..|:||.||.:...|||:||||||.|:|
Mouse   105 AWVPGELKLVTAAGDQTAKFWDVRAGELMG--TCKGHQCSLKSVAFPKFQKAVFSTGGRDGNIMI 167

  Fly   173 WDIRANLNMDLTSRVDNCIYSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLIS 237
            ||.|.|.......:|:....:.:|....||...:|::..........:..|:|.:.|||.:||:|
Mouse   168 WDTRCNKKDGFYRQVNQISGAHNTADKQTPSKPKKKQNSKGLAPAVDSQQSVTVVLFQDENTLVS 232

  Fly   238 CGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPYAGSSTFR-GFTNLIVDASGTRLYANCMDNTIYC 301
            .||.||:|||||||:|||||::||:......|.|:||.: |:::|::|::|:.|:|||.|:.||.
Mouse   233 AGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGTSTRKLGYSSLVLDSTGSTLFANCTDDNIYM 297

  Fly   302 YNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHAEEPLVALAGHTVE 366
            :|:......|:|.:.|..|||||:||.||||.::|:||||||.||||.:.....|...|.||:.|
Mouse   298 FNMTGLKTSPVAVFNGHQNSTFYVKSSLSPDDQFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQE 362

  Fly   367 VTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAERAEKYRGTASYVREFGKKAFGPSSGN 431
            ||.|.|..|....|.|||||...||||:.
Mouse   363 VTSVCWCPSDFTKIATCSDDNTLKIWRLN------------------------------------ 391

  Fly   432 HKYNLRDLESTPRSLKRLMDQNERTPGSVEKTTTKRSFLEMLGVAGQETEATEQPQKRAK--PLE 494
                 |.||                    ||...|.|.:..          |.|.:|..|  |:.
Mouse   392 -----RGLE--------------------EKPGDKHSIVGW----------TSQKKKEVKACPVT 421

  Fly   495 SRGRRLFGPSSQETACRHIQLQSINEEDASPSKRQKENSAAEDVSPLHKLLSTPSHSPLSENVNH 559
            .       ||||.|..:..:.:| :...:|||......|.|.|: ||..  |||:.|
Mouse   422 V-------PSSQSTPAKAPRAKS-SPSISSPSSAACTPSCAGDL-PLPS--STPTFS-------- 467

  Fly   560 VYTSPPTT-SAAAAAVAADALNPPPISA--------AIYSPTSNLPNYVLDGEAPHLGIMSPKR- 614
            |.|:|.|| |:.:...:..:::|.|:|:        ...:|:|:.|   :...|....|.||::
Mouse   468 VKTTPATTRSSVSRRGSISSVSPKPLSSFKMSLRNWVTRTPSSSPP---VTPPASETKISSPRKA 529

  Fly   615 -------------------KAKEKVD--WLTNIRKQKLMSGRAHVTLSEKISEEQQADVLA-SPR 657
                               :.|.::|  .|.:: |||.:.....||..:..:|..:.|:.. |..
Mouse   530 LIPVSQKSSQADACSESRNRVKRRLDSSCLESV-KQKCVKSCNCVTELDGQAESLRLDLCCLSGT 593

  Fly   658 LQSLRQSECSPRIHASPRRRISHTDGGGGT------------------------PAGSSSH--SH 696
            .:.|.|....|       .:.|.|:|.|.:                        |.|..|.  ..
Mouse   594 QEVLSQDSEGP-------TKSSKTEGAGTSISEPPSPVSPYASEGCGPLPLPLRPCGEGSEMVGK 651

  Fly   697 SQSQPKTPT-----SSRRNSETTLLRFFSIQRSSSVPAEETTTTNAAPSSSDPHPPAVTAPAATP 756
            ..|.|:...     :::|.:|.:         |...|:.:|.::......:.|.|..:     ||
Mouse   652 ENSSPENKNWLLAIAAKRKAENS---------SPRSPSSQTPSSRRQSGKTSPGPVTI-----TP 702

  Fly   757 LSMR 760
            .|||
Mouse   703 SSMR 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)dtl	NP_524871.1	WD40	52..393	CDD:475233	146/347 (42%)
		WD40 repeat	53..99	CDD:293791	13/45 (29%)
		WD40 repeat	105..143	CDD:293791	15/37 (41%)
		WD40 repeat	148..212	CDD:293791	24/63 (38%)
		WD40 repeat	220..263	CDD:293791	26/42 (62%)
		WD40 repeat	270..316	CDD:293791	17/46 (37%)
		WD40 repeat	324..361	CDD:293791	19/36 (53%)
		WD40 repeat	367..392	CDD:293791	12/24 (50%)
Dtl	NP_084042.1	WD 1	47..89		16/48 (33%)
		WD40 repeat	53..96	CDD:293791	14/50 (28%)
		WD40	65..389	CDD:475233	143/333 (43%)
		WD 2	96..135		19/40 (48%)
		WD40 repeat	102..138	CDD:293791	15/37 (41%)
		WD 3	138..178		22/39 (56%)
		WD40 repeat	143..199	CDD:293791	23/55 (42%)
		DDB1-binding motif. /evidence=ECO:0000250	168..171		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..212		4/22 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	197..203		1/5 (20%)
		WD 4	214..253		23/38 (61%)
		WD40 repeat	219..267	CDD:293791	26/47 (55%)
		DDB1-binding motif. /evidence=ECO:0000250	243..246		2/2 (100%)
		WD 5	269..308		13/38 (34%)
		WD40 repeat	274..312	CDD:293791	13/37 (35%)
		WD 6	313..354		24/40 (60%)
		WD40 repeat	320..357	CDD:293791	19/36 (53%)
		WD 7	358..398		22/100 (22%)
		WD40 repeat	363..388	CDD:293791	12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..445		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	460..491		10/40 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..546		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..705		21/129 (16%)