DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)dtl and AHI1

DIOPT Version :10

Sequence 1:NP_524871.1 Gene:l(2)dtl / 46326 FlyBaseID:FBgn0013548 Length:769 Species:Drosophila melanogaster
Sequence 2:NP_060121.3 Gene:AHI1 / 54806 HGNCID:21575 Length:1196 Species:Homo sapiens


Alignment Length:702 Identity:148/702 - (21%)
Similarity:242/702 - (34%) Gaps:199/702 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 YCPDFNPEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQCHFNAVFDL 107
            :|.||:....|.:|..|:.||| .|:......|:..             :.|.|   |.|.::||
Human   613 FCLDFSHNGRILAAACASRDGY-PIILYEIPSGRFM-------------RELCG---HLNIIYDL 660

  Fly   108 EWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSY--VGHTRSVKSAAFKRTDPAVFATGGRDGAI 170
            .|:......:::|.|.|||:|:   :.|...|::  :.|...|.:|.|......:..||..|..|
Human   661 SWSKDDHYILTSSSDGTARIWK---NEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMI 722

  Fly   171 LIWDIRANLNMDLTSRVDNCI----YSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQD 231
            .||.:.        .|.|:.|    :..|                         .|.|..|.|..
Human   723 RIWKVE--------MREDSAILVRQFDVH-------------------------KSFINSLCFDT 754

  Fly   232 NDTLISCGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPY------AGSSTFRG--FTNLIVDASGT 288
            ....:..|...|||.||:      .|.|.....|.:.:      ...:.|:|  .:.|.:..:|.
Human   755 EGHHMYSGDCTGVIVVWN------TYVKINDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGK 813

  Fly   289 RLYANCMDNTIYCYNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHA 353
            ||..:..|:|:...:|.....|.   :.|..|....|.|.|:|.|.:|.:||.|...|:||.:..
Human   814 RLLIHTKDSTLRIMDLRILVARK---FVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETG 875

  Fly   354 EE-----------PLVALAGHTVE--VTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAE 405
            |:           |:..::.|..|  |...|:|.:.  ||:....|     :.:..     .|||
Human   876 EQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQNE--PILLYIYD-----FHVAQ-----QEAE 928

  Fly   406 RAEKYRGTASYVREFGKKAFGPSSGNHKYN--LRDLESTPRSLKRLMDQNERTPGSVEKTTTKRS 468
            ..::|.||.            |..|.|:..  |......|......:|:...|    |.::||..
Human   929 MFKRYNGTF------------PLPGIHQSQDALCTCPKLPHQGSFQIDEFVHT----ESSSTKMQ 977

  Fly   469 FLEMLGVAGQETEATEQPQKRAKPLESRGRRLFGP---SSQETACRHIQLQSINEEDASPSKRQK 530
            .::      |..|...:..:......::......|   |||:                  ||.::
Human   978 LVK------QRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQ------------------SKLKQ 1018

  Fly   531 ENS-AAEDVSPLHK--LLSTPSHSPLSENVNHVYTSPPTTSAAAAAVAADALNPPPISAAIYSPT 592
            .|. .|:::  ||:  ...|...|...:..||...:.||.                  .|:|..|
Human  1019 SNMLTAQEI--LHQFGFTQTGIISIERKPCNHQVDTAPTV------------------VALYDYT 1063

  Fly   593 SNLPNYVLDGEAPHLGIMSPKRKAKEKVD-WLTNIRK-QKLMSGRAHV---TL-----------S 641
            :|..:.:.......:.:.     .|:..| |..:|.| |:......||   ||           |
Human  1064 ANRSDELTIHRGDIIRVF-----FKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERS 1123

  Fly   642 EKISEEQQADVLAS--PRLQSLRQSE-------CSPRIHASPRRRISHTDGG 684
            ..:|.|::..:..|  |:.||:.:::       .....|:..|:..||.|.|
Human  1124 PPLSPEEKTKIEKSPAPQKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQG 1175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)dtlNP_524871.1 WD40 52..393 CDD:475233 84/367 (23%)
WD40 repeat 53..99 CDD:293791 10/45 (22%)
WD40 repeat 105..143 CDD:293791 11/39 (28%)
WD40 repeat 148..212 CDD:293791 13/67 (19%)
WD40 repeat 220..263 CDD:293791 12/42 (29%)
WD40 repeat 270..316 CDD:293791 10/47 (21%)
WD40 repeat 324..361 CDD:293791 14/47 (30%)
WD40 repeat 367..392 CDD:293791 6/24 (25%)
AHI1NP_060121.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 56..186
Interaction with HAP1. /evidence=ECO:0000269|PubMed:23532844 141..434
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 215..242
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..327
WD40 <587..897 CDD:441893 79/345 (23%)
WD 1 607..649 11/49 (22%)
WD40 repeat 612..652 CDD:293791 12/52 (23%)
WD 2 652..691 14/44 (32%)
WD40 repeat 658..695 CDD:293791 11/39 (28%)
WD 3 695..735 12/47 (26%)
WD40 repeat 700..737 CDD:293791 12/44 (27%)
WD 4 742..781 13/69 (19%)
WD40 repeat 748..783 CDD:293791 10/40 (25%)
WD 5 797..837 10/42 (24%)
WD40 repeat 803..840 CDD:293791 8/39 (21%)
WD 6 841..880 14/38 (37%)
WD 7 885..926 9/52 (17%)
SH3_AHI-1 1055..1106 CDD:212746 11/73 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1115..1196 13/61 (21%)
Blue background indicates that the domain is not in the aligned region.

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