DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)dtl and DTL

DIOPT Version :10

Sequence 1:NP_524871.1 Gene:l(2)dtl / 46326 FlyBaseID:FBgn0013548 Length:769 Species:Drosophila melanogaster
Sequence 2:NP_057532.4 Gene:DTL / 51514 HGNCID:30288 Length:730 Species:Homo sapiens


Alignment Length:758 Identity:228/758 - (30%)
Similarity:336/758 - (44%) Gaps:145/758 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 PEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQC------HFNAVFDL 107
            |.|| |...|::.....|:||:|||:|.:.|.:|       |.||. ..:|      |:||||||
Human    49 PVPP-FGCTFSSAPNMEHVLAVANEEGFVRLYNT-------ESQSF-RKKCFKEWMAHWNAVFDL 104

  Fly   108 EWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILI 172
            .|.||:::.|:|:||.||:.|:|....:.|  :..||..|:||.||.:.:.|||.||||||.|::
Human   105 AWVPGELKLVTAAGDQTAKFWDVKAGELIG--TCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMV 167

  Fly   173 WDIRANLNMDLTSRVDNCIYSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLIS 237
            ||.|.|.......:|:....:.:|....||...:|::.............|:|.:.|||.:||:|
Human   168 WDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVS 232

  Fly   238 CGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPYAGSSTFR-GFTNLIVDASGTRLYANCMDNTIYC 301
            .||.||:|||||||:|||||::||:......|.||||.: |:::||:|::|:.|:|||.|:.||.
Human   233 AGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYM 297

  Fly   302 YNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHAEEPLVALAGHTVE 366
            :|:......|:|.:.|..|||||:||.||||.::|:||||||.||||.:....:|...|.||:.|
Human   298 FNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQE 362

  Fly   367 VTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAERAEKYR--GTASYVREFGKKAFGPSS 429
            ||.|.|..|....|.|||||...||||:.   .||.|....:|..  |.||              
Human   363 VTSVCWCPSDFTKIATCSDDNTLKIWRLN---RGLEEKPGGDKLSTVGWAS-------------- 410

  Fly   430 GNHKYNLRDLESTPRSLKRLMDQNERTPGSVEKTTTKRSFLEMLGVAGQETEATEQPQKRAKPLE 494
                                ..:.|..||.|..|::            |.|.| :.|:.:..|..
Human   411 --------------------QKKKESRPGLVTVTSS------------QSTPA-KAPRAKCNPSN 442

  Fly   495 SRGRRLFGPSSQETACRHIQLQSINEEDASPSKRQKENSAAEDVSPLHKLLSTPSHSP-----LS 554
            |      .|||  .||.......:.....:|:...| .|.|:..||:::..|..|.||     ..
Human   443 S------SPSS--AACAPSCAGDLPLPSNTPTFSIK-TSPAKARSPINRRGSVSSVSPKPPSSFK 498

  Fly   555 ENVNHVYTSPPTTSAAAAAVAADALNPPPISAAIYSPTSNL-PNYVLDGEAPHLGIMSPKRKAKE 618
            .::.:..|..|::|        ..:.||.....|.||...| |......:|.  .....:.:.|.
Human   499 MSIRNWVTRTPSSS--------PPITPPASETKIMSPRKALIPVSQKSSQAE--ACSESRNRVKR 553

  Fly   619 KVD--WLTNIRKQKLMSGRAHVTLSEKI-------------SEEQQADVLA---SPRLQSLRQSE 665
            ::|  .|.:::::.:.|......|..::             .|:...|.|.   |.:::....|.
Human   554 RLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGTSI 618

  Fly   666 CSPRIHASPRRRISHTDGGGGT------PAGSSSH--SHSQSQPKTPT-----SSRRNSETTLLR 717
            ..|....||     :.....||      |.|..|.  ....|.|:...     :::|.:|..   
Human   619 SEPPSPISP-----YASESCGTLPLPLRPCGEGSEMVGKENSSPENKNWLLAMAAKRKAENP--- 675

  Fly   718 FFSIQRSSSVPAEETTTTNAAPSSSDPHPPAVTAPAATPLSMR 760
                  |...|:.:|..:........|.|..:     ||.|||
Human   676 ------SPRSPSSQTPNSRRQSGKKLPSPVTI-----TPSSMR 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)dtlNP_524871.1 WD40 52..393 CDD:475233 148/347 (43%)
WD40 repeat 53..99 CDD:293791 14/45 (31%)
WD40 repeat 105..143 CDD:293791 15/37 (41%)
WD40 repeat 148..212 CDD:293791 23/63 (37%)
WD40 repeat 220..263 CDD:293791 26/42 (62%)
WD40 repeat 270..316 CDD:293791 19/46 (41%)
WD40 repeat 324..361 CDD:293791 19/36 (53%)
WD40 repeat 367..392 CDD:293791 12/24 (50%)
DTLNP_057532.4 WD 1 47..89 17/48 (35%)
WD40 repeat 55..96 CDD:293791 14/48 (29%)
WD40 <67..391 CDD:441893 146/333 (44%)
WD 2 96..135 19/40 (48%)
WD40 repeat 101..137 CDD:293791 16/37 (43%)
WD 3 138..178 21/39 (54%)
WD40 repeat 144..197 CDD:293791 20/52 (38%)
DDB1-binding motif 168..171 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 188..210 4/21 (19%)
Nuclear localization signal. /evidence=ECO:0000255 197..203 1/5 (20%)
WD 4 214..253 23/38 (61%)
WD40 repeat 219..312 CDD:293791 45/92 (49%)
DDB1-binding motif 243..246 2/2 (100%)
WD40 repeat 264..304 CDD:293791 18/39 (46%)
WD 5 267..308 16/40 (40%)
WD 6 313..354 24/40 (60%)
WD40 repeat 320..356 CDD:293791 19/35 (54%)
WD 7 358..398 21/42 (50%)
WD40 repeat 363..388 CDD:293791 12/24 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..443 14/90 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..498 10/33 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 599..631 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..703 11/72 (15%)

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