Protein Alignment l(2)dtl and Dtl

DIOPT Version :10

• Sequence 1: NP_524871.1
• Gene: l(2)dtl / 46326
• FlyBaseID: FBgn0013548
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_001414360.1
• Gene: Dtl / 305073
• RGDID: 1310439
• Length: 729
• Species: Rattus norvegicus
• Alignment Length: 792
• Identity: 229/792 - (28%)
• Similarity: 340/792 - (42%)
• Gaps: 214/792 - (27%)

  Fly    49 PEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQC------HFNAVFDL 107
            |.|| |...|.......||||:|||:|.:.|.:|        |.......|      |:||||||
  Rat    49 PVPP-FGCTFCTAPSMEHILAVANEEGFVRLYNT--------ESQTSKKTCFKEWMAHWNAVFDL 104

  Fly   108 EWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILI 172
            .|.||:::.|:|:||.||:.|:|....:.|  :..||..|:||.||.:...|||.||||||.|:|
  Rat   105 AWVPGELKLVTAAGDQTAKFWDVKAGELMG--TCKGHQCSLKSVAFSKFQKAVFCTGGRDGNIMI 167

  Fly   173 WDIRANLNMDLTSRVDNCIYSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLIS 237
            ||.|.|.......:|:....:.:|....||...:|::..........:..|:|.:.|||.:|::|
  Rat   168 WDTRCNKKDGFYRQVNQISGAHNTADKQTPSKPKKKQNSKGLAPSVDSQQSVTVVLFQDENTVVS 232

  Fly   238 CGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPYAGSSTFR-GFTNLIVDASGTRLYANCMDNTIYC 301
            .||.||:|||||||:|||||::||:......|.|:||.: |:::|::|::|:.|:|||.|:.||.
  Rat   233 AGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGTSTRKLGYSSLVLDSTGSTLFANCTDDNIYM 297

  Fly   302 YNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHAEEPLVALAGHTVE 366
            :|:......|||.:.|..|||||:||.||||.::|:||||||.||||.:.....|...|.||:.|
  Rat   298 FNMTGLKTSPLAVFNGHQNSTFYVKSSLSPDDQFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQE 362

  Fly   367 VTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAERAEKYRGTASYVREFGKKAFGPSSGN 431
            ||.|.|..|....|.|||||...||||:...|:...|.::......|:...:|.  || ||
  Rat   363 VTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPEGDKHSIVGWTSQKKKEV--KA-GP---- 420

  Fly   432 HKYNLRDLESTPRSLKRLMDQNERTPGSVEKTTTKRSFLEMLGVAGQETEATEQPQKRAKPLESR 496
                    .|.|.||.        ||                         .:.|:.:..|..|
  Rat   421 --------VSAPNSLS--------TP-------------------------AKAPRSQCSPSAS- 443

  Fly   497 GRRLFGPSSQETACRHIQLQSINEEDASPSKRQKENSAAEDVSPLHKLLSTPSHSPLSENVN--H 559
                 .|||..|.                       |.|.|:             ||..|.:  .
  Rat   444 -----SPSSARTP-----------------------SCAGDL-------------PLPSNTSTFS 467

  Fly   560 VYTSPPTT-SAAAAAVAADALNPPPISAAIYSPTS---NLPNYVLDGEAPHLGIMSPKRKAKEKV 620
            |.|:|.|| |..:...::.:::|.|       |:|   :|.|:|....:....:..|..:.|
  Rat   468 VKTTPVTTRSPVSRRGSSSSVSPKP-------PSSFKMSLRNWVTRTPSSSPPVTPPASETK--- 522

  Fly   621 DWLTNIRKQKLMSGRAHVTLSEKISEEQQADVLASPR-----------LQSLRQ---------SE 665
              :::.||       |.:.:|:|.|   |||..:..|           |:|::|         :|
  Rat   523 --ISSPRK-------ALIPVSQKSS---QADACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTE 575

  Fly   666 CSPRIHA--------SPRRRISHTDGGGGTPAGSSSHS-HSQSQPKTPTSSRRNSETTLLRFFSI 721
            ...::.:        |..:.:...|..|.|.:..:..: .|.|:|.:|.|.           |:.
  Rat   576 LDGQVESLHLDLCCLSGTQEVLSQDSAGPTKSSKTEGTGTSISEPPSPVSP-----------FAS 629

  Fly   722 QRSSSVP---------AEETTTTNAAP---------------SSSDPHPPAVTAPAA-------- 754
            :....:|         :|.....|::|               .:|.|..|:...|::
  Rat   630 EGCGPLPLPLGPCGEGSEMVGKENSSPENKNWLLAMAAKHKAENSSPRSPSSQTPSSRRQSRKTS 694

  Fly   755 ------TPLSMR 760
                  ||.|||
  Rat   695 PGPVTITPNSMR 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)dtl	NP_524871.1	WD40	52..393	CDD:475233	146/347 (42%)
		WD40 repeat	53..99	CDD:293791	13/45 (29%)
		WD40 repeat	105..143	CDD:293791	15/37 (41%)
		WD40 repeat	148..212	CDD:293791	24/63 (38%)
		WD40 repeat	220..263	CDD:293791	25/42 (60%)
		WD40 repeat	270..316	CDD:293791	18/46 (39%)
		WD40 repeat	324..361	CDD:293791	19/36 (53%)
		WD40 repeat	367..392	CDD:293791	12/24 (50%)
Dtl	NP_001414360.1	None