Protein Alignment MYH11 and Myo28B1

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Alignment Length: 1971
• Identity: 500/1971 - (25%)
• Similarity: 850/1971 - (43%)
• Gaps: 403/1971 - (20%)

Human    36 VWVPSEKQ------GFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQK-MNPPKFSKVEDMAEL 93
            |||..:..      .|.|..::.||...:|.:  :..|:..|...|:.| |:......||||..|
  Fly    13 VWVKPQNTTSEFAVPFGARIVRTEKTQTLVCD--DRNKQFWVPAGDVLKAMHITSQEDVEDMITL 75

Human    94 TCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIA 158
            ..|.|.::|.||:.||...|||||:|...|.:|||:.||||:.:.:.:|:.|...|:||||:||:
  Fly    76 GDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAIS 140

Human   159 DTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEK 223
            |.|::.:.:.:|:|.::.:|||||||||:||.::||||.::..|..                :|:
  Fly   141 DNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW----------------IEQ 189

Human   224 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTF 288
            |:::||||:|||||||||:|||||||||:|.|.|...|.|.||.|:.|||||||.:.|:||||.:
  Fly   190 QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNY 254

Human   289 HIFYYMIAG--AKEKMRSDLLLEGFNNYTFLS-NGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQ 350
            ||||.|:||  ..|:.|..|..:..:.|.:|: .|...:|...|.:.|.:...||.::.|..||.
  Fly   255 HIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEV 319

Human   351 LSILKVVSSVLQLGNIVF--KKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRD 413
            .|||.:::::|.|||:.|  .:..|...|.:.|....|:|..|:||.::....::....|.|..:
  Fly   320 WSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGE 384

Human   414 VVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSF 478
            .|..:.:||.|....:|..|:.|:.:|..|:.|:|:.::|...|..:.:|:|||.|||.|:.|||
  Fly   385 HVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSF 449

Human   479 EQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLD 543
            |||||||.||.|||.|...:|.:||:|||.|.|.|..|:| .|.|..::||..  .|..:::|:|
  Fly   450 EQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGM--KPMNLMSLID 511

Human   544 EECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLND 608
            ||..|||.||::.:|||..:.|:...:.|.|..:... |.|.||||.|.||...:|.||.|..:.
  Fly   512 EESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSL-FGIRHYAGVVMYNPLGFLEKNRDSFSG 575

Human   609 NVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMT 673
            ::.:|:..|::|::.|::..              |..:.:|.|..     |:...::..|..||.
  Fly   576 DLRTLVQRSTNKYLVDIFPH--------------EMPMDTAKKQP-----TLCVKFRNSLDMLMR 621

Human   674 TLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 738
            ||....|.|:|||.||..|.....|..|.:.|||.:|::|..||.|.|:|.|..::.|.:||.:|
  Fly   622 TLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLL 686

Human   739 AANAIPKGFMD----GKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMA 799
            .....|....|    .:|.|.:   ||..|.: .:.|::|:|.|....|.||.:|...:...|:.
  Fly   687 VPPVGPLEQCDCRKLARQICEV---ALPADSD-RQYGKTKLFLRDEDDASLELQRSQLMLKSIVT 747

Human   800 FQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL-FTKVKPLL---QVTRQEEE 860
            .|...|..|.|: :.||.::  |:..:||.....|:.|.:|..|. |.::...:   |:|.:...
  Fly   748 IQRGIRRVLFRR-YMKRYRE--AIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTM 809

Human   861 MQAKEDELQKTKERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923
            ::.:..:||.........::..|:|  .:|.:||.:|: ||:                    .||
  Fly   810 VRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEE-LLK--------------------LAK 853

Human   924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
            .:|.||:|...:  |:|:::|.|:.|.|::      |..|::|:.|.|||..|.:..|..:.:.|
  Fly   854 MKEAEELLRLQQ--LKEQKEREQREQQEKR------LQEEQRLKAEAAARNALAMAAVQQKRRTK 910

Human   989 KLEDE------------------------------------ILVMDDQNNKLSKERKLLEERISD 1017
            .::.|                                    |..:.:....:..|..  ::.:.|
  Fly   911 PVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESS--KQMVDD 973

Human  1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE------LEKLKRKLEGDASDFHE 1076
            :...|.:|.:.|  |.||.|    :.|...:||.|...:..:      |:.......|.|:..||
  Fly   974 VFRFLNDEPDAA--LRKLNN----ISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHE 1032

Human  1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
            :        ..||..|.|.|..:        ||:|.|...|..:|    .:.||.:.:.|.....
  Fly  1033 R--------KPLKKSLLKHEHPI--------DEMASKAIWLTILR----FMGDLPDVVSSPTLHV 1077

Human  1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
            ...|....||        ..|.:|.||...:..:|..        ::.:.:...|.|.:.||..|
  Fly  1078 FDNENLMSDL--------ASLLNTSDSYKPRLFVRQS--------QRRIPKPLASGEKEAQEFYQ 1126

Human  1207 -------KHAQAV--------------EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
                   .|.:.:              :|:..|:.:    :..|:.::.:..:....|:..|...
  Fly  1127 HWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICK----QLYLNPSRSSYSRGWLLLSLCLSCF 1187

Human  1251 GQAKQEVEHKKK-------KLEA--QVQELQSKCSDGERARAELNDKVHKLQN------EVESVT 1300
            ..:|:...|.:.       :|:|  .:|.|:....:|.|.:.....::|.::.      ::..:.
  Fly  1188 PPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMD 1252

Human  1301 GMLNEAEGKAIKLAKD-------------------VASLSSQL-------QDTQELLQEETRQKL 1339
            |.....:..|...|::                   |.||:.:|       :...:.:.|..:::|
  Fly  1253 GQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQRQL 1317

Human  1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN-IQLSDSKKKLQDFASTVEAL----EE 1399
            :...||...:|   ......|..|:.|.....:...|| ::..:.:.:.:...:.|.||    |.
  Fly  1318 DAPWKLYIRKE---MFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFVEY 1379

Human  1400 GKKRF--------------------QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
            |....                    ::.|||.::..   ||.|:|    .:.:::|.:||:::..
  Fly  1380 GPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLI---AATYEK----SSYVKEEQNDLLLEAQ 1437

Human  1445 NQRQ----LVSNLE---KKQRKFDQLLAEEKNISSK------------YADERDRAEAEAREKET 1490
            .:.:    |.::|.   :..|.|:.:..|...:.|.            ..||.::..|
  Fly  1438 KRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLA------- 1495

Human  1491 KALSLARALEEALEAKEEL-----ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR-------A 1543
             :...:..|:..:|:.::|     :..|.:|:.      ||..|..:.::.:..:.|       |
  Fly  1496 -SCCFSEVLKVHVESDDKLHVMTFQHVNFVLQC------SSAQDANEVINYMLDNLRQRSSYGVA 1553

Human  1544 LETQMEEMKTQLEELED----------ELQA-TEDAKLR-------------------LEVNMQA 1578
            |:..:|      .:|||          |.:| ...|:|.                   |..|::.
  Fly  1554 LDPVVE------GDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRV 1612

Human  1579 L---------------KGQFERDLQARDEQNEEKRRQLQ-RQLHE--YETELEDERKQRALAAAA 1625
            |               :|:|:...:.....|..:|||.. .||.|  :...|:.::  ..|:..:
  Fly  1613 LATLTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDK--APLSKFS 1675

Human  1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
            .:.|:..|....::.....   ::|:.....:...|.|..|  .:...:.|.||..|.::.....
  Fly  1676 PEPLKAPLLKAVVKVPPLF---QQALVMHHHILKYMGDIAR--SNLPVNTDLIFQPALQHPLLCD 1735

Human  1691 SLEADLMQLQEDLAAAERARKQADL---------EKEELAEELASSLSGR-NALQDE-KRRLEAR 1744
            .|...||:...|..::|..::..||         ....:..||...|..| :||.|. .:||:..
  Fly  1736 ELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALADACLKRLKRS 1800

Human  1745 IAQLEEELEEEQGNMEAMSDR 1765
            :||.:.:.......:|.:..|
  Fly  1801 LAQGQRKKAPHLIEVEGIQQR 1821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670	10/45 (22%)
		MYSc_class_II	99..778	CDD:276951	260/687 (38%)
		Actin-binding. /evidence=ECO:0000250	668..690		11/21 (52%)
		Actin-binding. /evidence=ECO:0000250	769..783		4/13 (31%)
		Myosin_tail_1	855..1935	CDD:460256	199/1132 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		2/15 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	260/687 (38%)
		IQ	765..785	CDD:197470	5/21 (24%)
		Atrophin-1	<820..>946	CDD:460830	31/154 (20%)
		MyTH4	1031..1239	CDD:470587	44/247 (18%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	12/93 (13%)
		B41	1248..1429	CDD:214604	29/190 (15%)
		PH-like	1454..1547	CDD:473070	16/106 (15%)
		MyTH4	1674..1819	CDD:214535	29/149 (19%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020