DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH11 and jar

DIOPT Version :10

Sequence 1:NP_001035203.1 Gene:MYH11 / 4629 HGNCID:7569 Length:1979 Species:Homo sapiens
Sequence 2:NP_001014650.2 Gene:jar / 42889 FlyBaseID:FBgn0011225 Length:1268 Species:Drosophila melanogaster


Alignment Length:1342 Identity:386/1342 - (28%)
Similarity:605/1342 - (45%) Gaps:285/1342 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    34 RLVWVPSEKQGFEAASIKEEKGDEVVVELVENG-KKVTVGKDDI-QKMNPPKFSKVEDMAELTCL 96
            :||||....:|:....|.|....|..|...:.. .|.|...||| ...:.|:  ..:|..||..|
  Fly     6 QLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQ--DHDDNCELMLL 68

Human    97 NEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHL-PIYSEKIVDMYKGKKRHEMPPHIYAIADT 160
            |||:.|.||:.||:...||||.....:.||||:.: .:|:...:..|.|:...|:|||::||||.
  Fly    69 NEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADK 133

Human   161 AYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEKQL 225
            |.|.|...:..|||:.:|||||||||:||.:::||..   ||    |::         |.:|.::
  Fly   134 AIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---SH----DSA---------GPIETKI 182

Human   226 LQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHI 290
            |.|||:|||||||||.:|:|||||||||.:::|....:||..|..|||||||...|:.:||.:|:
  Fly   183 LDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHV 247

Human   291 FYYMIAGAKEKMRSDLLLEGFNNYTFLS--------------------------NGFVPIPAAQD 329
            ||.::|||.:::|..|.|...::|.:||                          .|.:..|...|
  Fly   248 FYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDD 312

Human   330 DEMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKK----ERNTDQASMPDNTAAQKVCH 390
            .:.|....:|:..:|.|:.|:|.|..:|::||.||||.|::    .|...|.|.....:......
  Fly   313 YQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSG 377

Human   391 LMGINVTDFTRSILTPRIKVGR------DVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNK 449
            |:|::.|:. |:.|..|:...:      .|:.......:|..|.:|||||.|.|||..|:..:|:
  Fly   378 LLGVDQTEL-RTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQ 441

Human   450 ALDKTHRQGASF-LGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEW 513
            ::.   .|.::| :|:|||||||.|.||||||.||||.|||||:.||..:...|||.|:|||:..
  Fly   442 SIP---FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNV 503

Human   514 NFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQ--- 575
            ..|.| .|.|..|||||..:|  |:..|||||...||.:...|..::.....:|.:...|:.   
  Fly   504 PEITF-TDNQDIIELIEAKSN--GIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRL 565

Human   576 -----LKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGL 635
                 |:|:..|.:.|:||.|.||...::.||.|.|:.::..|:....:..:..|:         
  Fly   566 KAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF--------- 621

Human   636 DQMAKMTESSLPSASKTK---KGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKL 697
                       ||.|.|.   |..|.:||..:|.|||:||..|.....||:|||.||.:....:.
  Fly   622 -----------PSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQF 675

Human   698 DAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGF--MDGKQACILMIKA 760
            :..|.|.||:|:|.:..:.:...|:|:|::|.:....|:    :.:|...  :..:..|..|.::
  Fly   676 EGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYK----SVLPPELVSLPARTFCEAMFQS 736

Human   761 LELDPNLYRIGQSKIFFRTGVLAHLEE------ERDLKITD-----------VIMAFQAMC---- 804
            |.|....::.|.:|:|||.|.....:.      |..|.|..           |..|..|:|    
  Fly   737 LNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKL 801

Human   805 ------------------RGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 851
                              ||:||||....|.|.:..:..|:.|....:::.:.            
  Fly   802 RNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASG------------ 854

Human   852 LQVTRQE------EEMQAKEDELQKTKERQQKAENELKEL----EQKHSQLTEEKNL-LQEQLQA 905
            |::.|:|      :..:..:|.::|.|...:..:.|:..:    ....::||.:.|. |:||.||
  Fly   855 LKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQA 919

Human   906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE---RKKMAQQM-------- 959
            |       |:.|:|...:..|.|....|.|.:.:.||...::|:||   |:|.|:..        
  Fly   920 E-------EQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEED 977

Human   960 ----LDLEEQLEEE----EAARQKLQLEKVTAEAKIK-------KLEDEILVMDDQNNKLSK--E 1007
                |.|:||||:|    ...||:|:.|:...|..::       ::||...|:.:..|..|.  .
  Fly   978 RRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGP 1042

Human  1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK------ 1066
            .||:.  .|.:.:|:|         ::..||.|:      ||.:::...:|:.:..|.|      
  Fly  1043 NKLIS--FSQVVSNIA---------SRYLNKSEN------VRAQQQALGKQKYDLSKWKYSELRD 1090

Human  1067 ----------LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
                      ||....:||.::....|..|:.:.:....|.|   ...|...|.|.|...|    
  Fly  1091 AINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENE---RAPRSVMEAAFKQPPL---- 1148

Human  1122 ELEGHISDLQEDLDSE---------RAARNKAEKQKRDL------GEELEALKTELEDTLDSTAT 1171
                 :..:||.:.::         ||  |..:..||.|      |:.:              |.
  Fly  1149 -----VQPIQEIVTAQHRYFRIPFMRA--NAPDNTKRGLWYAHFDGQWI--------------AR 1192

Human  1172 QQELRAKR--------EQEVTVLKKALDEE--TRSHEAQVQE 1203
            |.||.|.:        ..::.:.:.:|:|.  ||...|::.|
  Fly  1193 QMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILE 1234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH11NP_001035203.1 Myosin_N 31..76 CDD:460670 12/42 (29%)
MYSc_class_II 99..778 CDD:276951 251/729 (34%)
Actin-binding. /evidence=ECO:0000250 668..690 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 769..783 6/13 (46%)
Myosin_tail_1 855..1935 CDD:460256 93/429 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..889 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1807
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1873..1979
C-terminal 1942..1979
jarNP_001014650.2 Myosin_N 7..49 CDD:460670 12/41 (29%)
MYSc_Myo6 71..754 CDD:276833 251/729 (34%)
CBD_MYO6-like 765..913 CDD:409646 27/159 (17%)
ERM_helical <954..1020 CDD:466641 18/65 (28%)
MYO6_MIU_linker 1002..1093 CDD:480843 21/107 (20%)
MyUb_Myo6 1076..1116 CDD:439319 7/39 (18%)
Myosin-VI_CBD 1160..1246 CDD:465157 18/91 (20%)
Blue background indicates that the domain is not in the aligned region.

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