Protein Alignment MYH11 and Mhcl

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Alignment Length: 1859
• Identity: 500/1859 - (26%)
• Similarity: 834/1859 - (44%)
• Gaps: 355/1859 - (19%)

Human    28 ADWAAKRLVWVPSEKQGFEA------ASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSK 86
            ||.:....||: ..:.||.|      ||...::.:::.:.|:.||:::||.:||::|.|.|....
  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDL 562

Human    87 VEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMP 151
            |||:.||..||||||||.||:||.|.||:|.:|...:||||...|.:||||:|.|::|.|..:||
  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627

Human   152 PHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSF 216
            ||:|::|.|||||:::.|.|||::..|.||:||:.:.|..:.|||:.|.::.           :|
  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYN-----------NF 681

Human   217 AYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQ 281
            ...|....|.   .|||||||.||..|.|::|..:.:.::||.||.|..|:::..|.|:.||.|:
  Fly   682 INAEKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRR 743

Human   282 ARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEM-----FQETVEAMA 341
            ...|.:|||...::|||...::.:|.||...:..  |:.|:.:....:|..     |..||:|..
  Fly   744 LGHEHSFHIMTRLLAGAAGLLQKELHLENITSED--SHPFISLSQKLEDRHRAANDFMRTVQAFE 806

Human   342 IMGFSEEEQLSILKVVSSVLQLG--NIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRS-- 402
            .:....:....|..:::::..||  .:......:|.:....:.|||:|...|:|:|:.|.:.:
  Fly   807 TLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAF 871

Human   403 -ILTPRIKVGRDVVQKAQTK----EQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFL 462
             :..|....|.....|:.|.    |.|...:|||....|......::..:|:.:..:....||.:
  Fly   872 GLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIM 936

Human   463 GILDIAGFEIFEVN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFID 517
             ::|..||:    |          :...|..||..|:||.||:||..:..::.|.:|     .::
  Fly   937 -LIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVE 991

Human   518 FGLDLQ------PCIELIE---------------RPNNPPGVLALLDEECWFPKATDKSFVEKLC 561
            ..:||.      |.|.||:               |.::..|:|.|||||..:|.:.|.:|:|:|.
  Fly   992 IEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF 1056

Human   562 TEQGSHPKFQKPKQLKDKTEFSIIHYAG--KVDYNASAWLTKNMD-PLNDNVTSLLNASSDK--- 620
            :..|........::.....:|.:.|..|  .|.|....|:..:.: |...|..|||..||.:
  Fly  1057 SHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEIN 1121

Human   621 --FVADLWKDVDRIV------GLDQMAKMTESSLPSASKTKKGMFRTVGQL-YKEQLGKLMTTLR 676
              ::..|.:....:|      ||:....:...|....|.|..|:.|....| .|..:..::.|||
  Fly  1122 RLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLR 1186

Human   677 NTTPNFVRCIIPNHEKRSGK-----------------------LDAFLVLEQLRCNGVLEGIRIC 718
            .|..:||.|.:..|  .:||                       ::..|:..|||.:.|||..|:.
  Fly  1187 RTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLH 1249

Human   719 RQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKAL-ELDPNLYRIGQSKIFFRTGVL 782
            |.|||..:...||.:|:.:||.:     ....|...:..|.|: |||...||||.|:|.||:|||
  Fly  1250 RLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVL 1309

Human   783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK 847
            :.||.:||:.::|.|:..||.||||||||..::|:.|..|::.||||..|:|.:|:|.||||..:
  Fly  1310 SELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVR 1374

Human   848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
            |.|||.|.|.||:::...:||...:.:.:|.|.:..|::.::.:|.                 |:
  Fly  1375 VTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLE-----------------AK 1422

Human   913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
            ..|:.|.||    |.....|....|||.|       .|||.|:.:::.|...:::..:...:||:
  Fly  1423 LSELTVDLA----EERSTAHIATERLEAE-------TAERLKLEKELGDQTNKVKNLQETTEKLE 1476

Human   978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL-----KN 1037
            :|.:.|:                               |||  |...|:|.|:|...:     |.
  Fly  1477 MELICAK-------------------------------SDL--NGISEDEDAENEDGVGGGVYKL 1508

Human  1038 KHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
            |:|.:..|||...::    .|...::|..||:.||...||.:|::.:.:..:.:.|.:..|...|
  Fly  1509 KYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNE 1573

Human  1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
            :......|:::.|:.|...||.|:.:.....||:.:..||.|:.:..::|    :.|:|.|..||
  Fly  1574 MNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK----DVLQAEKFTLE 1634

Human  1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1228
            .||..|....|.   :|:::..|::.|:|.|.....:                |:..|.:|:|..
  Fly  1635 QTLADTRLDLEF---KEEKLASLQRELEEMTFGGGTE----------------EEFAQLRRSKNE 1680

Human  1229 LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
            .::..:..|:|..::||::::|.|||..:|   ..||...:|          ||.|...:..:|:
  Fly  1681 TERRAKEQEEELDEMAGQIQLLEQAKLRLE---MTLETMRKE----------ARRESQQRDEELE 1732

Human  1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET---RQKLNVSTKLRQLEEERNSL 1355
                       |..|...|..|   :|..||:...|   |.|   |:|..:..:|..:|:
  Fly  1733 -----------EVRGNGYKKIK---ALECQLETEHE---ERTLLLREKHELERRLSSMED----- 1775

Human  1356 QDQLDEEME--AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418
            :|::|.:.|  ..|.|.|.:......|.|::.:|:    .::|...||..    |..|..|.|:.
  Fly  1776 RDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLE----RLKADTPGKTL----IRQLRNQLEDA 1832

Human  1419 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
            .:|.....|.:...:.||.::....|...:..::.|::..                |..|||||.
  Fly  1833 ESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERAN----------------AAHRDRAEL 1881

Human  1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
            :|:.:|.:        ||..|..::...|.|.|..|.           .||.|.|.....:|.:.
  Fly  1882 QAQIEENE--------EELGELMKKYSATVKQLNTEQ-----------INVSEAEFKLNEMEAER 1927

Human  1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYET 1610
            ..:|.|:.||:..|...|:..   :.:|..:..:.|   ::|::|.|..:..|.:|:.|::.::.
  Fly  1928 NNLKEQVAELQHRLDNVENLG---DPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKE 1989

Human  1611 ELEDERKQRALAAAAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
            .||              ||:.::   |..|:||...||          |.|..::|.:.|.....
  Fly  1990 ALE--------------KLQNEVTQSKMREMQAQDVIK----------KSQKSLRDMREEFHAVS 2030

Human  1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE---KEELAEELASSLSGRNAL 1734
            :...|.....|:.|||.:.:|::...|:.||..|  .::.|||:   :||..|||:.|
  Fly  2031 SREQESLTRRKDLEKKVEQMESEGAALKNDLRLA--LQRIADLQQAMEEEGEEELSES------- 2086

Human  1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
             ||.......|:.||:.|...         .|::::||:
  Fly  2087 -DESLSSVGSISDLEDRLRPV---------HVKRSSQQS 2115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670	13/50 (26%)
		MYSc_class_II	99..778	CDD:276951	219/762 (29%)
		Actin-binding. /evidence=ECO:0000250	668..690		7/21 (33%)
		Actin-binding. /evidence=ECO:0000250	769..783		9/13 (69%)
		Myosin_tail_1	855..1935	CDD:460256	213/942 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	460/1699 (27%)
		MYSc_Myo18	575..1305	CDD:276837	219/762 (29%)