DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH11 and Prm

DIOPT Version :9

Sequence 1:NP_001035203.1 Gene:MYH11 / 4629 HGNCID:7569 Length:1979 Species:Homo sapiens
Sequence 2:NP_523982.2 Gene:Prm / 39002 FlyBaseID:FBgn0003149 Length:879 Species:Drosophila melanogaster


Alignment Length:870 Identity:231/870 - (26%)
Similarity:422/870 - (48%) Gaps:80/870 - (9%)


- Green bases have known domain annotations that are detailed below.


Human  1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
            |..:..||..|..||:||:.||..|.:.|::|.||..::..:...||:.......|.|...||:.
  Fly    34 LSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDA 98

Human  1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
            |:..|:|.|::.....|.....:::||.:.:.:..||:|...:.||..:|:|...:.|..:|..:
  Fly    99 ELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQ 163

Human  1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
            :....:.|...|....|||..:              :|||.|:.:|...|..::...:....:.|
  Fly   164 IESYNKEKIVSEKHISKLEVSI--------------SELNVKIEELNRTVIDISSHRSRLSQENI 214

Human  1312 KLAKDVASLS--------------SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
            :|.|||..|.              |||:|.:..|::|.|::..:.:.|.|:|.|.:|:::||:||
  Fly   215 ELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279

Human  1363 MEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
            .||:.:|||.:...|...:..:.|. .:.|:..|.:||.::::|..|..|.:..|......:.||
  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344

Human  1427 KTKNRLQQELDDLVVDLDNQ----RQLVS--------NLEKKQRKFDQLL---AEEKNISSKYAD 1476
            |.|.||..|::.|::||:..    |:|..        |:|.|.|..:.::   ..::::.:|:||
  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHAD 409

Human  1477 ERDRAEAEAREKETKALSLARALEEALEAKE---ELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538
                              |.|.:.|..:.|:   :|.|.||.|..::.:...:.:::.:.:||||
  Fly   410 ------------------LVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELE 456

Human  1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
            ...|.||.:.:|:....:|.|...:|.|....||..:....:...||.|..:||:.|..|:|...
  Fly   457 LELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSI 521

Human  1604 QLHEYETE-LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR---EEAIK----QLRKLQAQ 1660
            ::.:.... :|.|.:.:......||||:..:.:||:..|.|.|..   ::.||    ||.:|||.
  Fly   522 EIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAH 586

Human  1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
            .:|.||:|:   |:.|: :|.|   :::...|..:|.:::..|.:|.||::..:|:.||.|..:.
  Fly   587 YEDVQRQLQ---ATLDQ-YAVA---QRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRIN 644

Human  1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
            ...:...:|...|.:||..::.:..:.||....:....:|.:|...:.:.:..::..|:....|.
  Fly   645 ELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKL 709

Human  1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
            |:.::.||.:.|.|..:|.|:|....:..|..|:.|||:|..||.::|:|.|......|.|::|:
  Fly   710 ETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKE 774

Human  1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
            :.:||:|:|.|:::|.....::..:|..|::...:|||.|.|..||:.....|:.||||:.|.:.
  Fly   775 RTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDR 839

Human  1921 NEAMGREVNALKSKLRRGNETSFVP 1945
            .:.....:|.:::|.|....||.||
  Fly   840 ADTAESSLNIIRAKHRTFVTTSTVP 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH11NP_001035203.1 Myosin_N 34..71 CDD:280832
Myosin_head 87..778 CDD:278492
MYSc_class_II 99..778 CDD:276951
Actin-binding. /evidence=ECO:0000250 668..690
Actin-binding. /evidence=ECO:0000250 769..783
Myosin_tail_1 855..1935 CDD:279860 225/858 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..889
FAM76 <997..1089 CDD:292665
V_Alix_like <1027..1299 CDD:187408 48/181 (27%)
crotonase-like 1073..>1131 CDD:304874 4/13 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1807 11/55 (20%)
DUF2570 1787..>1874 CDD:305162 29/86 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1873..1979 22/73 (30%)
C-terminal 1942..1979 3/4 (75%)
PrmNP_523982.2 Myosin_tail_1 <34..853 CDD:279860 225/857 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.