Protein Alignment MYH11 and Myo61F

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1104
• Identity: 328/1104 - (29%)
• Similarity: 539/1104 - (48%)
• Gaps: 190/1104 - (17%)

Human    97 NEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTA 161
            :|.:.:.||::|:...|||||.|...:.|||||.||||::..|..|:.|..:||||||:|:.|.|
  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNA 114

Human   162 YRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSH---KGKKDTSITQGPSFAYGELEK 223
            :||::::...|.:|.:||||:||||.:|||:|::|..:.:.   :|.||
  Fly   115 FRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKD---------------- 163

Human   224 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTF 288
            :||::||:|||||||||.:|||||||||::.|.||..|..:|.||..|||||||.:.|...||.|
  Fly   164 KLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNF 228

Human   289 HIFYYMIAGAKEKMRSDLLLE-GFNNYTFLSNGF-VPIPAAQDDEMFQETVEAMAIMGFSEEEQL 351
            ||||.::|||.|.:..:|.|| ..:.|::|::|. ..:....|.:.|::..:|:.::.|::|||.
  Fly   229 HIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQR 293

Human   352 SILKVVSSVLQLGNIVFKKERNTDQASMPD--NTAAQKVCHLMGINVTDFTRSILTPRIKVGRDV 414
            .|..:|:|:|.|||:.|.:.....:.:..|  .|||:    |:|:|.::...::....|....||
  Fly   294 EIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAAR----LLGVNASELEAALTHRTIDARGDV 354

Human   415 VQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALD--KTHRQGASFLGILDIAGFEIFEVNS 477
            |.....:|.|.:|.:|||||.|:|||.|::.|:|.:|.  :|.....:.:|||||.|||||:.||
  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNS 419

Human   478 FEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALL 542
            |||.|||:.||||||||.......||:||:||||||..::: .|.:....|||..:.  |::::|
  Fly   420 FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEEKHK--GIISIL 481

Human   543 DEECWFP-KATDKSFVEKLCTEQGSHPKF----QKPKQLKD---KTEFSIIHYAGKVDYNASAWL 599
            ||||..| :.|||:|:|||..:...|..:    :.|..:|.   :.||.::||||:|.|:.:.:|
  Fly   482 DEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFL 546

Human   600 TKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLY 664
            .||.|.|..::...|:.:.:..|.:.:               .|..|.|..:.:..:.:     :
  Fly   547 DKNNDLLFRDLKETLSKAGNGIVRNCF---------------PEKELRSLKRPETAITQ-----F 591

Human   665 KEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQ 729
            :..|..||..|....|:::|||.||..:.:...:..|||.|::..|::|.:|:.|.||..|..::
  Fly   592 RASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYE 656

Human   730 EFRQRYEILAANAIP--KGFMDGKQACILMIKALELDPNLYRIGQSKIFFR-TGVLAHLEEERDL 791
            .|.:||:.|:.:..|  ||....|.....::|.|..|...||:|::|:|.| ...|...|:....
  Fly   657 LFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQE 721

Human   792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR 856
            |..::....||..:|.:.|:.:.|.:.|:.   ::|..|...|
  Fly   722 KKHEIAAIIQAHWKGLMQRRKYLKLRAQVI---IMQSYCRRKL---------------------- 761

Human   857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---LYAEAEEMRV 918
                       .|:..:::::|.::::...:......:..|...|:..|..:   |...|:|:..
  Fly   762 -----------AQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPT 815

Human   919 RLAAKK--------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
            ::..|.        :|...|||.:.        |....:..|.|:..|               ||
  Fly   816 KVLDKSWPHAPGHCEEASGILHRLH--------RLHLARIYRLKLTPQ---------------QK 857

Human   976 LQLE-KVTAEAKIKKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
            .|.| ||.||...|..::.......   |.:::.||.   .:|::|...:....|:.
  Fly   858 RQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEH---IQRVNDFVASTFGSEQL-------- 911

Human  1037 NKHESMISELEVRLKKEEKSRQ---------------ELEKLKRKLEGDASDF----HEQIADLQ 1082
             |::|..::.:   :...|||.               :..|.|.:|..|..||    |..  ||
  Fly   912 -KYQSFCTKFD---RHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHND--DL- 969

Human  1083 AQIAELKMQLAKKEEELQAALARLDD---------------EIAQKNNALKKIRELEGHISDLQ 1131
             .:..:.:.|.|.:.:|...:.|:.:               .|..:|:....:.:.:|.:.|:|
  Fly   970 -MVIRIPLDLKKDKGDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQ 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951	259/697 (37%)
		Actin-binding. /evidence=ECO:0000250	668..690		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	769..783		5/14 (36%)
		Myosin_tail_1	855..1935	CDD:460256	55/326 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	259/697 (37%)
		Myosin_TH1	863..1049	CDD:461801	34/189 (18%)