Protein Alignment MYH11 and didum

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Alignment Length: 1712
• Identity: 492/1712 - (28%)
• Similarity: 804/1712 - (46%)
• Gaps: 290/1712 - (16%)

Human    36 VWVPSEKQGFEAASIKE--EKGDEVVVELVENGK----KVTVGKDDIQKM-NPPKFSKVEDMAEL 93
            :|||.....:|:|:::|  .||...:....::||    |:.....|:..: ||.......|:..|
  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78

Human    94 TCLNEASVLHNLRERYFS-GLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAI 157
            :.|:|..||||||.|:.. .:||||.|:..|.:|||..:|:|...|:..|:|....::.|||:|:
  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143

Human   158 ADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELE 222
            |:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|.      |.||        :|
  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE------SETQ--------VE 194

Human   223 KQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEKSRAIRQARD 284
            :::|.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.
  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259

Human   285 ERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVP-IPAAQDDEMFQETVEAMAIMGFSEE 348
            ||.:||||.:.| |:.|. .:|:|:..:.:.||:.|..| |....|.|.|.|||:||.::|||.:
  Fly   260 ERNYHIFYQLCA-ARSKY-PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322

Human   349 EQLSILKVVSSVLQLGNI-VFKK------ERNTDQASMPDNTA-AQKVCHLMGINVTDFTRSILT 405
            :...|:|:::.:|.|||| |.||      |.::|...:..|.. .|....|:.::..|..|.:|.
  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387

Human   406 PRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGF 470
            .:|:...:.|....:.|.|..|.:||||..|.:||::|:..:||:|:...:| .||:|:|||.||
  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGF 451

Human   471 EIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNP 535
            |.||||||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||:|||   :.
  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE---SR 512

Human   536 PGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLT 600
            .|||.||||||..||.:|:|:..||..:....|.|:||:  ...|.|.|.|::..|:|:.:.:|.
  Fly   513 LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLE 575

Human   601 KNMDPLNDNVTSLL---NASSDKFVADLWKDVD--------------RIV---GLDQMAKMTESS 645
            ||.|.::..:|.:|   |.|..|.|..| :::|              |:|   |..|....|...
  Fly   576 KNRDTVSKELTQVLSESNMSLAKQVMTL-EEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRR 639

Human   646 LPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNG 710
            :..:.:.:|    |||..::|.|..|::||..|||::||||.||.:|.:.|.:...:::|||..|
  Fly   640 VVPSKQHRK----TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700

Human   711 VLEGIRICRQGFPNRIVFQEFRQRYEILA-ANAIPKGFMDGKQACILMIKALELDPNLYRIGQSK 774
            |||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:.||.|.::
  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQ 763

Human   775 IFFRTGVLAHLEEERD-----------------------LKITDVIMAFQAMCRGYLARKAFAKR 816
            ||||.|.:|.||:.|.                       |:|..||...|...||||||    :|
  Fly   764 IFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLAR----ER 824

Human   817 QQQLTAMKVIQRNCAAYLKL----RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQK 877
            .|::       |...|.|.|    |.|...|.:.:::..:...              :|..|...
  Fly   825 TQKM-------REARAGLILSKYARGWLCRRRYLRLRHSISGI--------------QTYARGML 868

Human   878 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR------------LAAK-----KQ 925
            |.|       |...:.:....:|.|......|...|.:.|.|            ||.:     |.
  Fly   869 ARN-------KFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKA 926

Human   926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
            |.:.|.| ||.:....|::...:|....::.:...:|:.:..|....:.||:|:| |.||:.|.:
  Fly   927 EAKTISH-MENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFKNV 989

Human   991 ----EDEILVMDDQNNKLSKER----KLLEER-------ISDLTTNLAEEEEKAKNLTKL----- 1035
                :|:..:::..|.:|..||    :||||.       ||...|...|.||..:.:.::
  Fly   990 KAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAK 1054

Human  1036 ------KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA- 1093
                  :|:.:.|::|::.|...|  :.|...|.|..:|.:.....|:::.|.|....|..:.|
  Fly  1055 NAEVNQRNQEDRMLAEIDNRELNE--AYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKAS 1117

Human  1094 ----KKEEELQAALAR--LD----DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
                :.|:::..|.|:  ||    .::..||.:......|...:..:.|:           ||||
  Fly  1118 NASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEE-----------EKQK 1171

Human  1149 -RDLGEELEALKTELEDTLDS------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
             :.|.|:...|.:..:.|.||      ....::||::.:|..|.:|         |..::.|:..
  Fly  1172 HKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIK---------HGVEINELNA 1227

Human  1207 KHAQAVEELTEQLEQFKRAKANL---DKNKQTLEKENADLAG----ELRVLGQAKQEVEHKKKKL 1264
            :||...||:..:.|:..:.||.|   .::.::||.|:..:.|    ||       .|..|.:|.:
  Fly  1228 QHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNEL-------MEAFHSQKLI 1285

Human  1265 EAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA-----EGKAIKLAKDVASLSSQ 1323
            ..|:: ||::...:......|:..::.:|.||.:.:..::.|:     :.....|.::...|..:
  Fly  1286 NRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRE 1350

Human  1324 LQDTQE---LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM---------------EAKQNLE 1370
            ||....   |:|||.:.   .:.||:...::...|:.:::|||               ..||..:
  Fly  1351 LQKAVAQFLLVQEELKL---ANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQ 1412

Human  1371 RHISTLNIQLSDSKKKLQDFAS-----TVEALEEGKKRF-------QKEIENLTQQYEEKAAAYD 1423
            .....:....||..|.||...|     ||..|..|...:       ..::.|......|..:.:.
  Fly  1413 NPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFV 1477

Human  1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
            ...|..:|....:::.|:.|.|...|: ||.|:....|:.:    ..:::..:::........|.
  Fly  1478 IQIKKMHRTPHPIENRVIWLVNSITLL-NLMKQYGDVDEYV----KFNTEKQNQQQLKNFNLFEY 1537

Human  1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV--GKNVHELEKSKRALETQ---- 1547
            ....|.|...|.:||     :.:...:|..::...:.:.|::  |:..|.:.....::...
  Fly  1538 RRVILDLIVNLYQAL-----IMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPE 1597

Human  1548 ------MEEMKTQLEELEDELQ 1563
                  .:::..|||....:.|
  Fly  1598 HGGGPAWKQLIGQLEHFYKQFQ 1619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670	11/45 (24%)
		MYSc_class_II	99..778	CDD:276951	284/712 (40%)
		Actin-binding. /evidence=ECO:0000250	668..690		12/21 (57%)
		Actin-binding. /evidence=ECO:0000250	769..783		7/13 (54%)
		Myosin_tail_1	855..1935	CDD:460256	163/825 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	284/712 (40%)
		IQ	900..922	CDD:197470	4/21 (19%)
		SMC_prok_B	<942..1365	CDD:274008	99/452 (22%)
		Myo5_CBD	1424..1792	CDD:271254	35/206 (17%)