Protein Alignment MYH11 and Mhc

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1944
• Identity: 784/1944 - (40%)
• Similarity: 1187/1944 - (61%)
• Gaps: 41/1944 - (2%)

Human     9 DDEKFLFV--DKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTV 71
            |...:|||  ::..|:.   ...:.:|:..|:|.||:|:....||..|||.|.|.| :.|:...:
  Fly    12 DPTPYLFVSLEQRRIDQ---SKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGETRDL 72

Human    72 GKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSE 136
            .||.:|::||||:.|.|||:.||.||:||||||||:||::.|||||||||||.:||||..|:|:.
  Fly    73 KKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTN 137

Human   137 KIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASS 201
            :...||:||:|:|:||||:||:|.||..||.:..:||:|.||||||||||||||||.|.|.|.:|
  Fly   138 RCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS 202

Human   202 HKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGA 266
            .|       |...:.:.|.||.|::|.||:||||||||||:|||||||||||||:|..||.:.||
  Fly   203 KK-------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260

Human   267 NIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRS-DLLLEGFNNYTFLSNGFVPIPAAQDD 330
            :||||||||:|.|.|...||::||||.:::|:...::. .||.:...:|..:|.|.|.:.:..|.
  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDA 325

Human   331 EMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGIN 395
            |.|..|.:|..|:||:::|:..:.::.::|:.:|.:.||:....:||.........:|..|.|.:
  Fly   326 EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD 390

Human   396 VTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGAS 460
            ..:..:::|.||||||.:.|.:.:..:|...::.||.|..::|||:|::.:.|:.|| |.::...
  Fly   391 TAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQH 454

Human   461 FLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 525
            |:|:||||||||||.|.|||||||:|||||||.|||.||:|||||||||||||.|||||:|||.|
  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLC 519

Human   526 IELIERPNNPPGVLALLDEECWFPKATDKSFVEKLC-TEQGSHPKFQKPKQLK---DKTEFSIIH 586
            |:|||:   |.|:|::|:||..||||||::|.|||. |..|....|||||..|   ....|:|.|
  Fly   520 IDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAH 581

Human   587 YAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASK 651
            |||.|.||.:.||.||.|||||.|......|.:|.:.:::.|.....|..:.||        ..:
  Fly   582 YAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--------GGR 638

Human   652 TKK-GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGI 715
            .|| |.|.||...|||||..||||||:|.|:||||||||..|:.|.:||.||:.||.||||||||
  Fly   639 GKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGI 703

Human   716 RICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTG 780
            ||||:|||||:::.:|:.||:|:....: :|....|:|..::||.::|..:.||:|.:|:|||.|
  Fly   704 RICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAG 767

Human   781 VLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845
            ||..:||.||.::..::...||..||||:||.|.|.|:|..|:||:|||...||:||.|.|::|:
  Fly   768 VLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLW 832

Human   846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
            .||||||.|:|.|:|:...|::.:|.:|.........||||..:::|..||..|.:.|..|....
  Fly   833 QKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGAL 897

Human   911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
            .:.:|...:|.|:|.:||..|.:::.||.:|||...||..::||..|::..|::.:|:.|...||
  Fly   898 QDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQK 962

Human   976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
            .:.:|.|.:.:|:.|.|||...|:..|||:||:|:..|........|...|:|..:|.|:|.|.|
  Fly   963 AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLE 1027

Human  1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
            ..:.|||..|::|:|.|.::||.|||:|||.....|.:|||:....||:..:.:|::||.:..|:
  Fly  1028 QTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAK 1092

Human  1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
            |:||........::|:||:..|.:|:|::::||.||.|||||:.||..|||.|...||:...:|:
  Fly  1093 LEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATS 1157

Human  1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
            .|.||..|||.|::.|::.|:|....||:.:..:|:||..||.|:.||::|..:.||..:|.|..
  Fly  1158 AQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNE 1222

Human  1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
            ...:..||...:..:...|...|...|:|:..:.|:|||..:..|...:.:....||..|...:.
  Fly  1223 YYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLL 1287

Human  1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
            ..|.|||.:..:|:|...||::||:||:.|..||:|::..:..|.|.||.:.::|::|::||.|.
  Fly  1288 RQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEG 1352

Human  1366 KQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQ---KEIENLTQQYEEKAAAYDKLE 1426
            |.:|:|.:|..|.:....:.|.: |..:..|.|||.|::.|   .|.|...:...:|...   ||
  Fly  1353 KADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIG---LE 1414

Human  1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
            |||.||..|::||.:::|....:.:..||||:.||:::.|.|......|.|.|.::.|.|...|:
  Fly  1415 KTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTE 1479

Human  1492 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
            ...|..|.||..|..|.:.|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..||
  Fly  1480 LFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE 1544

Human  1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
            |.|..|:..|:..||.::.:..::.:.:|.:|.::|:.|..|:..||.|...:..||.|.|.:|.
  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAE 1609

Human  1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
            |...|||||.|:.:||:..|.|.|...||.|.:::.|.|:||.|..||:.:.:||:.......:|
  Fly  1610 ALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISE 1674

Human  1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEE 1750
            ::|.:|:.:|.:.:..|..|:|.|:||:.|..:..|:| :.:|.:|| :...||:||:.:..|..
  Fly  1675 RRANALQNELEESRTLLEQADRGRRQAEQELADAHEQL-NEVSAQNASISAAKRKLESELQTLHS 1738

Human  1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
            :|:|.....:...::.:||...|.:|::||..|:..||..|..|:.||:|.|||:.:|.|.|...
  Fly  1739 DLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANA 1803

Human  1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
            ....|..|..||.::.:||.:::.|.|....|.|:|::.::::||:..|.|::||..|:.::..:
  Fly  1804 LKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVD 1868

Human  1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
            |...::|..|||:|||||.:....|..||.|:||:||.|..:...:.::..::|.|.|:
  Fly  1869 KLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670	17/44 (39%)
		MYSc_class_II	99..778	CDD:276951	340/684 (50%)
		Actin-binding. /evidence=ECO:0000250	668..690		16/21 (76%)
		Actin-binding. /evidence=ECO:0000250	769..783		8/13 (62%)
		Myosin_tail_1	855..1935	CDD:460256	365/1084 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		19/55 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979		23/67 (34%)
		C-terminal	1942..1979
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	15/42 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	340/684 (50%)
		Myosin_tail_1	842..1922	CDD:460256	365/1083 (34%)