Protein Alignment MYH11 and ck

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 2205
• Identity: 548/2205 - (24%)
• Similarity: 893/2205 - (40%)
• Gaps: 511/2205 - (23%)

Human    25 VAQADWAAKRLVWV-PSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDD-----------IQ 77
            |.:.|:     :|: |:..:.|:.|.     |..||   ...|:::.|..||           |:
  Fly     4 VTRGDY-----IWIEPASGREFDVAI-----GARVV---SAEGRRIQVRDDDGDEVWLAPERRIK 55

Human    78 KMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMY 142
            .|:......||||..|..|:||.:|.||..||...|||||:|...|.||||:.||||:...:.:|
  Fly    56 AMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLY 120

Human   143 KGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKD 207
            |.:|..|:||||:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..
  Fly   121 KERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW--- 182

Human   208 TSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYL 272
                         :|:|:|:|||||||||||||::|||||||||:|.|:|...|.|.||.||.||
  Fly   183 -------------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYL 234

Human   273 LEKSRAIRQARDERTFHIFYYMIAG--AKEKMRSDLLLEGFNNYTFLSNG-FVPIPAAQDDEMFQ 334
            |||||.:.|...||.:|:||.::||  |.||.|.||.:..  :|.:|:.| .:......|...|.
  Fly   235 LEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA--DYKYLTGGNSITCEGRDDAAEFS 297

Human   335 ETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKE--RNTDQASMPDNTAAQKVCHLMGINVT 397
            :...||.::.||::|...|:|:::::|..|||.:|..  .|.|...:|::...::|..|:|:.:.
  Fly   298 DIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQ 362

Human   398 DFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFL 462
            ....::....:....:.|....:::|:....:|..|..|.|:|..|:.::|.|:.|......:.:
  Fly   363 PLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAI 427

Human   463 GILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIE 527
            |:|||.|||.|:.|||||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..::
  Fly   428 GVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALD 491

Human   528 L--IERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGK 590
            |  |::.|    ::||:|||..|||.||::.:.||....|||..:.|||. ...|.|.:.|:||.
  Fly   492 LIAIKQLN----IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGV 551

Human   591 VDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLW-KDVDRIVGLDQMAKMTESSLPSASKTKK 654
            |.|:...:|.||.|..:.::..|::.|::||:..:: :|:       :|...|....|
  Fly   552 VFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI-------EMGAETRKRTP------- 602

Human   655 GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICR 719
                |:...:::.|..||.||.:..|.|:|||.||..|:....|..|...|||.:|::|.|||.|
  Fly   603 ----TLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRR 663

Human   720 QGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAH 784
            .|:|.|..|:||.:||..|.. .:|.......||....|.|:.|..:.|::|.:|:|.:......
  Fly   664 AGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLF 727

Human   785 LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL-FTKV 848
            ||:|||..:|..|:..|...||::.|:.|.:.:   .|...:||....|.:.:.::..|: :.::
  Fly   728 LEQERDRVLTRKILILQRSIRGWVYRRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRL 789

Human   849 KPLLQ---VTRQEEEMQAKEDELQ----------------------KTKERQQKAENELKELEQK 888
            :.|::   ::.:...::.....||                      ::..|:..|....::|..:
  Fly   790 QALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLE 854

Human   889 HSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
            |.|..|   :||.:...|.||.....:....:|  :|...:.|||:|.|
  Fly   855 HKQFAE---VLQLRKLEEQELLHRGNKHAREIA--EQHYRDRLHELERR---------------- 898

Human   954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
                   :::||||.    |:::::.........:|.|:.:    |....:......|.:..||.
  Fly   899 -------EIQEQLEN----RRRVEVNMNIINDAARKQEEPV----DDGKLVEAMFDFLPDSSSDA 948

Human  1019 TTNLAEEEEKAKN-LTKLKN-KHESMISELEVRLKKEEKSRQELEKL--------------KRKL 1067
            .|.....|....| |...:| ..:.:|:.:.:...:|:.|..:.:|.              |:.|
  Fly   949 PTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKAL 1013

Human  1068 EGDASDFHEQIADLQAQIAEL------------------KMQLAKKEEELQAALARLDDEIAQKN 1114
            :......|.|...|.||...:                  :|.......::.|.|.|
  Fly  1014 KHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGR--------- 1069

Human  1115 NALKKIRELEGHISDLQEDL---DSERAARNK----AEKQKRDLGEELEALKTELEDTLDS---- 1168
            |.::.....|..:..|..|.   ...|:.|:|    ..|:|..|||::.....:.|.|.||
  Fly  1070 NFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSW 1134

Human  1169 -----TATQQE---------LRAKREQEV--TVLKKALDEETRSHEAQ----------------- 1200
                 |:..::         |||:...|:  .:.|:..:...:|..|:
  Fly  1135 LQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEK 1199

Human  1201 --------VQEMRQKHAQAVEELTE---------------QLEQFKRAK------ANLDKNKQTL 1236
                    ::|....:|...||..:               :|:..|..|      ..:|.|.:||
  Fly  1200 FVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTL 1264

Human  1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS----DGERARAELNDKVHKLQNEVE 1297
            ..::|..|.||                    ..:|..|.|    .|......|.|||..|.:..:
  Fly  1265 LADSATTAREL--------------------CNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGD 1309

Human  1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL---QEETRQKLNVSTKLRQL----------- 1348
            .|...:::.|..|.:......:...:|...:|:.   .|.|..::..:...:|:
  Fly  1310 HVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRC 1374

Human  1349 --EEERNSL-QDQLDEEMEAKQNLERHISTL-----NIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
              ||:...: ..|...|.....::||..:.|     :..||...|.::.:|:.|  |:..||.:.
  Fly  1375 DKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV--LQAYKKSYY 1437

Human  1406 KEIENLTQQYEEKAAAYDK----------LEKTKN---RLQQELDDLVVD--------LDNQRQL 1449
            .:.:....:.:|...:|.|          .|..:|   .|.:  :|:::.        :|:|.|:
  Fly  1438 VKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPK--NDVIIAVNWTGVYVVDDQEQV 1500

Human  1450 VSNL----------EKKQRKFDQLLA------EEKNISSKYADE-RDRA-----EAEAREKETKA 1492
            :..|          :|..:.|.|..:      ||....|..|:: ||..     ..:.|.|...|
  Fly  1501 LLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIA 1565

Human  1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD------------VGKNVHELEKSKRALE 1545
            |...||..:.          ...|.....||:..:|:            :|:.....|:.....|
  Fly  1566 LQDYRAPSDG----------TSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAE 1620

Human  1546 TQMEEMKTQLEELEDEL------QATEDAKLRLEVNMQAL---------------------KGQF 1583
            | :..:.|..:..:|.|      :|....:|.:..|..|:                     |...
  Fly  1621 T-VYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTM 1684

Human  1584 ERDLQARDEQNEEKRR--------QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
            .:.|....:::||..|        .|.|:|...|...|    :...|.||..|..|||.....:.
  Fly  1685 SKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----EACFAFAAILKYMGDLPSKRPRM 1745

Human  1641 DSAIKG------------REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
            .:.|..            |:|...||.|   |:.|.:..:.:.|.
  Fly  1746 GNEITDHIFDGPLKHEILRDEIYCQLMK---QLTDNRNRMSEERG-------------------- 1787

Human  1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN--ALQDEKRRLEARIAQLEEELEEEQ 1756
            .:||.|...|.|..:.          |.:||...|..|.  ..||...||:..|...:.:....|
  Fly  1788 WELMWLATGLFACSQG----------LLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQ 1842

Human  1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
            ..:||:.   .|.||...::.....|:.: .:.:.|.|.:....|...|..|...||
  Fly  1843 VEVEAIQ---HKTTQIFHKVYFPDDTDEA-FEVDSSTRAKDFCNNISQRLSLRTSEG-------- 1895

Human  1822 TIAALEAKIAQLEEQVEQ----------------EARE----------------KQAATKSLKQK 1854
              .:|..|||.....|.:                :||.                |:..|.::..|
  Fly  1896 --FSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGK 1958

Human  1855 DKKLKEILLQVEDERKMAEQY----KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
            |:....|....::..|:...|    :|:|.|..|.|.:::  ..|.::|.|.|....|:|
  Fly  1959 DRNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVR--FGENKQELQAIPQMLREL 2016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670	11/56 (20%)
		MYSc_class_II	99..778	CDD:276951	265/686 (39%)
		Actin-binding. /evidence=ECO:0000250	668..690		11/21 (52%)
		Actin-binding. /evidence=ECO:0000250	769..783		3/13 (23%)
		Myosin_tail_1	855..1935	CDD:460256	243/1351 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		5/45 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979		12/42 (29%)
		C-terminal	1942..1979
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	265/686 (39%)
		MyTH4	<1138..1245	CDD:214535	13/106 (12%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	22/117 (19%)
		B41	1251..1467	CDD:214604	43/237 (18%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	17/99 (17%)
		SH3	1560..1624	CDD:473055	13/74 (18%)
		MyTH4	1701..1849	CDD:214535	39/184 (21%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	17/107 (16%)
		B41	1856..2068	CDD:214604	33/174 (19%)
		FERM_C2_MyoVII	2064..2159	CDD:270020