Protein Alignment MYH11 and Myo31DF

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Alignment Length: 1025
• Identity: 325/1025 - (31%)
• Similarity: 516/1025 - (50%)
• Gaps: 128/1025 - (12%)

Human    87 VEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMP 151
            |:|...|..::....:.|||:|:.:|.||||.|..||.:|||:.:.||..:.:..|||::..|..
  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73

Human   152 PHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSF 216
            ||::||||:|||.:.|.::|..||.:|||||||||.:|.:::|:|.|.::          ||.:
  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNA----------QGQN- 127

Human   217 AYGELEK---QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRA 278
               |:|:   .|:|:|.|||.||||||.:|||||||||::.|.||.....||..|..|||||||.
  Fly   128 ---EIERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRV 189

Human   279 IRQARDERTFHIFYYMIAGAKE-KMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAI 342
            ::|...||.||.||.::.||.: ::|...|.:....|.:|:.|.:.|...:.|  ::.|..|...
  Fly   190 VQQQPGERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDILTEKSD--YKGTCNAFKT 252

Human   343 MGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPR 407
            :|||.:|..:|.:.:::||.|||:.|  :...|:..:.:....:....|:.:..|:.:.::....
  Fly   253 LGFSTDEVQTIWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRV 315

Human   408 IKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKAL----DKTHRQGASFLGILDIA 468
            |..|.:|:||.....||::..:|||||.|:|||.||::|:|:|:    .||..:..|.:|:|||.
  Fly   316 IAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIY 380

Human   469 GFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPN 533
            |||||:.|||||.||||.||||||||...:...||||||||||||..|::..:...| :|:|:|:
  Fly   381 GFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPH 444

Human   534 NPPGVLALLDEECW-FPKATDKSFVEKLCTEQGSHPKFQ----KP--KQLKDKTEFSIIHYAGKV 591
            .  |::|::||.|. ..|.||.:.:..:......||.:.    ||  |:||.:.:|.|.||||.|
  Fly   445 K--GIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDV 507

Human   592 DYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGM 656
            .||.:.::.||.|.|..:...||:.|.|..::::|.:     |...:.|.|:..|
  Fly   508 IYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPE-----GAQDIKKTTKRPL---------- 557

Human   657 FRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQG 721
              |.|.|::..:..|:.||....|.:||||.||..|.|...|...|..|:|..|:||.:|:.|.|
  Fly   558 --TAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAG 620

Human   722 FPNRIVFQEFRQRYEILAANAIPKGFMDG--KQACILMIKALELDPNLYRIGQSKIFFRT-GVLA 783
            |.:|..:.:|..||::::....| .|..|  :....::|:..:...:: :.|.:|||.|: ..|.
  Fly   621 FVHRQRYDKFLLRYKMISQYTWP-NFRAGSDRDGVRVLIEEKKFAQDV-KYGHTKIFIRSPRTLF 683

Human   784 HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKV 848
            .||.:|:..|..::...|...||::.|:.|.|.:..:|    |.|...|| |||::        |
  Fly   684 ALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAIT----IVRAYKAY-KLRSY--------V 735

Human   849 KPLLQVTRQEEEMQ--AKEDELQKTKERQQKAENELKELEQ-------KHSQLTEEKNLLQEQLQ 904
            :.|....|:.::|:  .|..:..:.....:|.|.:|..:..       .|.....|...|:.|:.
  Fly   736 QELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQII 800

Human   905 AETEL------YAEAEEMRVRLAAKKQELE--EILHEMEARLEEEEDRGQQLQAE---------- 951
            |.|.|      :.:|........|..||..  |..:.....:......|:..|..
  Fly   801 AATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFN 865

Human   952 --RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL--------EDEILVMDDQNNK--- 1003
              .|:..:..:..:..:.:.:..:.|.:..|.|  .||::|        .|:::|.....||
  Fly   866 HFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRT--IKIRELTSISVSPGRDQLIVFHSSKNKDLV 928

Human  1004 ---LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
               .|:...|.|:||.::...:.            |..|:...:||.|.:
  Fly   929 FSLESEYTPLKEDRIGEVVGIVC------------KKYHDLTGTELRVNV 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951	259/695 (37%)
		Actin-binding. /evidence=ECO:0000250	668..690		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	769..783		5/14 (36%)
		Myosin_tail_1	855..1935	CDD:460256	41/239 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		3/30 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	259/695 (37%)
		Myosin_TH1	801..977	CDD:461801	31/180 (17%)