Protein Alignment MYH11 and ninaC

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Alignment Length: 1126
• Identity: 262/1126 - (23%)
• Similarity: 474/1126 - (42%)
• Gaps: 248/1126 - (22%)

Human    16 VDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEV---VVELVENGKKV-TVGK--- 73
            ::||..|.|           :.|...:..|....|:.|  ||:   :.|::|..:.| |:.|
  Fly   263 LEKNAENRP-----------MMVEMVEHPFLTELIENE--DEMRSDIAEMLELSRDVKTLYKEPE 314

Human    74 ------------DDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVN 126
                        :..:||.|      ||:|.|....:.:::.:||.|...|..|::.|...:.:|
  Fly   315 LFVDRGYVKRFDEKPEKMYP------EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLN 373

Human   127 PYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKV 191
            ..:....:.::....|:.|.|.|..|||:::||.||:.||..:|.|.|:.:|||.:||:.|.:.:
  Fly   374 SNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLL 438

Human   192 IQYLAVVASSHKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRIN 256
            |::|..:...::|            |.|.:|..:.....::    ||.|..|::|:|......:.
  Fly   439 IKHLCYLGDGNRG------------ATGRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLT 487

Human   257 FDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMR-SDLLLEGFNNYTFLSNG 320
            |..||.:.||....|:|||.|.......:..||||||......::.: .:..|:...||.:|.
  Fly   488 FGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLR-- 550

Human   321 FVP--IPAA-----QDD-----EMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERN 373
             ||  :|.:     :||     |.::|....:..:.|:.::..::.||::::|.:|||.|:  :|
  Fly   551 -VPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFR--QN 612

Human   374 TDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQ-TKEQADFAVEALAKATYE 437
            ...|.:.:.....::..|:.::...|..| ||..|.|...:.::.| |.|:|..|.:|:|...|.
  Fly   613 GKYAEVENTDIVSRIAELLRVDEKKFMWS-LTNFIMVKGGIAERRQYTTEEARDARDAVASTLYS 676

Human   438 RLFRWILTRVNKALDKTHRQGASF----------LGILDIAGFEIFEVNSFEQLCINYTNEKLQQ 492
            ||..:|:.|:|        ...||          :.|.|:.|||.|..|..|||.||..||::|.
  Fly   677 RLVDFIINRIN--------MNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQY 733

Human   493 LFNHTMFILEQEEYQREGIE---WNFID--FGLDLQPCIELIERPNNPPGVLALLDE---ECWFP 549
            .:|..:||.|..|.:.|.|:   .||.|  ..||     .|:.:|:   |:..::|:   .|
  Fly   734 HYNQRIFISEMLEMEAEDIDTINLNFYDNKTALD-----NLLTKPD---GLFYIIDDASRSC--- 787

Human   550 KATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLL 614
              .|:..:....:|:  |.:|.|.   ...||.|:.||.|::.|:..|:...|.|.:...:....
  Fly   788 --QDQDLIMDRVSEK--HSQFVKK---HTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETF 845

Human   615 NASSDKFVADLWKDVDRIVGLDQMAKMTESSLP-------SASKTKKGMFRTVGQLYKEQLGKL- 671
            .:|.|:.:        .::..:|:.|....::|       ..|:.|.....|:......|:..|
  Fly   846 RSSLDESI--------MLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLR 902

Human   672 ----------MTTLRNTTPN------FVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQ 720
                      :|.|:..:.|      |||||..:.|.:.....:.:|.:|::..|||:.:...::
  Fly   903 TLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQK 967

Human   721 GFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR---TGVL 782
            ||.:|:.|.||.:||:.||.:......|. |..|.|:...|:::.  :.:|::|:|.|   ...|
  Fly   968 GFSSRLPFDEFLRRYQFLAFDFDEPVEMT-KDNCRLLFLRLKMEG--WALGKTKVFLRYYNDEFL 1029

Human   783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRN-WQWWRLFT 846
            |.|.|   |::..||.. |:|.|..||||.....:......|..:.:..|..|::. ::.:|...
  Fly  1030 ARLYE---LQVKKVIKV-QSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRV 1090

Human   847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
            ::.||:.               :|:.:..:...:.::...:|    ..||::.|
  Fly  1091 RLPPLVN---------------EKSGQLNENTADFIRPFAKK----WREKSIFQ----------- 1125

Human   912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
                             .:||...||.::..:..||:....::|...:......:..|     ::
  Fly  1126 -----------------VLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFE-----RI 1168

Human   977 QLEKVTAE------AKIKKLE---DEILVMD-----DQNNKLSKE---RKLLEERISD------- 1017
            .:.:|.:.      ..|||:.   |:|...|     |..|.:|::   .:||.:.:.|
  Fly  1169 NMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSP 1233

Human  1018 -----------LTTNLAEEEE 1027
                       ||.|..::|:
  Fly  1234 LQRNPSMTSCALTYNAYKKEQ 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670	11/63 (17%)
		MYSc_class_II	99..778	CDD:276951	189/734 (26%)
		Actin-binding. /evidence=ECO:0000250	668..690		9/38 (24%)
		Actin-binding. /evidence=ECO:0000250	769..783		4/16 (25%)
		Myosin_tail_1	855..1935	CDD:460256	30/208 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		1/23 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	5/29 (17%)
		MYSc_Myo21	346..1022	CDD:276848	189/734 (26%)