Protein Alignment MYH11 and CG31638

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_723186.2
• Gene: CG31638 / 33910
• FlyBaseID: FBgn0051638
• Length: 704
• Species: Drosophila melanogaster
• Alignment Length: 813
• Identity: 171/813 - (21%)
• Similarity: 311/813 - (38%)
• Gaps: 213/813 - (26%)

Human   934 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998
            |.||..|.|...::.|.:|              |..||..:..|:||..
  Fly    34 MSARYGETEWEARESQRQR--------------ELHEARARAAQMEKTM---------------- 68

Human   999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL 1063
                          :..||.|.|..|:..|.:|                    :..|:|:|.::|
  Fly    69 --------------KWWSDCTANWREKWSKVRN--------------------ERNKAREESKQL 99

Human  1064 KRKLEG---DASDFHEQIADLQAQIAELKMQLAK------------------KEEELQAALARLD 1107
            ..||:|   :|.....:..||:.||.:||.::.|                  ::.|.....|...
  Fly   100 SLKLDGVMKEAHSLKREKNDLELQITQLKKEMEKVHTLMMKHAGQFHRADTSEDAEANGRDANCS 164

Human  1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK-------TELEDT 1165
            .:|:  ::.||.|...:|.::.|..|:              :||..|..|:|       ||
  Fly   165 PDIS--SDGLKNINSEDGLVTKLPNDV--------------KDLDIEEFAMKGAMPKHLTE---- 209

Human  1166 LDSTATQQELRAKRE------------QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
            ||..|..:|.|..::            |::::|:..|||..::.:|:..|..:.| :::|:||.:
  Fly   210 LDEAAAAEEKRLIQQLSKDDFDEDYLLQKISMLQLRLDEAQKTLQAERDEKLELH-KSIEKLTLE 273

Human  1219 L-------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
            :       |:.:.||....:...||::::   ..|:|::..:.||....::.||.::.||
  Fly   274 IQDVRGRQEEMRSAKQEAVRELLTLQEQH---RAEMRIVNNSLQEEIAARENLERRLTEL----- 330

Human  1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
                 |.||    ..||.|..|..|.....|.:.:.:.:|...|.::|:|.||....:.|.....
  Fly   331 -----RTEL----EHLQAENASEWGKRERLESEKLAMERDNKKLRAELRDYQERSDRKCRPMQAN 386

Human  1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
            ..:||.|::|.:....::.|...:...|::.::..|.:|..:.::.:.:.:.|       ||.::
  Fly   387 DVELRALQQELSERNKEISEVKMSHAKLKKLLAETNTELGHAVRRAEQYEAEV-------KRLRQ 444

Human  1407 EIENLTQQYEEKAAAYDKLEKTKN---RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
            .:|.|.:   |.|.|.|:|:...|   |||:..|:||...:..:..:.:|:.::....||
  Fly   445 RVEELKR---ELAGAEDELDSAVNQVRRLQRSNDELVGQTEGLQVQIQHLQNRRAPSPQL----- 501

Human  1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
                     |.....:.|.|        .|:|...:....:....::.......|.||.:.....
  Fly   502 ---------RGMGGVQLRNK--------IAVELPNDCLPNINDLRQIFDDSQAGLRSSHNGSDAA 549

Human  1534 VHELEKSKRALETQMEEMKTQLEELEDELQATE-----------DAK-LRLEVNMQALKG---QF 1583
            :|.....||:..|:    :|.|::.:....|:.           ||| ..||.|:...|.   :|
  Fly   550 MHHAASVKRSSHTE----RTLLQQQQSSAAASAAAAAAAAAAFFDAKPTHLEENIFESKSRNLEF 610

Human  1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
            ||..|..|..:.:.....|||      ...:.|...|.::|::..|...||.......|::..::
  Fly   611 ERAKQKFDNPHGQHHHHHQRQ------RSGNGRYGSAGSSASRANLALPLKGTTNGGSSSVSSKD 669

Human  1649 EAIKQL-RKLQAQMKDFQR---ELEDARASRDE 1677
            |..:|| .|.|:....:.|   .|:..:.|.||
  Fly   670 ELNRQLYEKEQSAGAGYARNSINLDGLKVSDDE 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951
		Actin-binding. /evidence=ECO:0000250	668..690
		Actin-binding. /evidence=ECO:0000250	769..783
		Myosin_tail_1	855..1935	CDD:460256	171/813 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
CG31638	NP_723186.2	Smc	<233..>496	CDD:440809	66/290 (23%)