Protein Alignment MYH11 and Myo10A

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Alignment Length: 2205
• Identity: 532/2205 - (24%)
• Similarity: 886/2205 - (40%)
• Gaps: 537/2205 - (24%)

Human    85 SKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLP-IYSEKIVDMYKGKKRH 148
            |.||||..|..|:|||:|.|||.||..|||||::|...:.|||||..| .|..::...|.|:...
  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219

Human   149 EMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQG 213
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||            ::..|
  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLA------------AVVPG 269

Human   214 PSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRA 278
            ...|...:.:|:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.
  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRI 333

Human   279 IRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIM 343
            :.||..||.:|:||.::.|..|..||...|...:.|.:|:.|.....:.:.|  ::....||.::
  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD--WESLQGAMQVL 396

Human   344 GFSEEEQLSILKVVSSVLQLGNIVFKKER---NTDQASMPDNTAAQKVCHLMGINVTDFTRSILT 405
            |.||.|:..|::|:::||.|||:.|.:.:   ..:...:..:...:...||:.|:.....|: ||
  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-LT 460

Human   406 PRIKVGRDVVQKAQTK---EQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDI 467
            .|....|  .::..|.   :||..|.:|.|||.|..||.|:::|:|..:.|.....|..:.||||
  Fly   461 SRTTEAR--AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDI 523

Human   468 AGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERP 532
            .|||....||||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.:
  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK- 586

Human   533 NNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASA 597
             .|.|:..|||:|..||:|||.||:||..........:.:|:  ....||.:.||||:|.|....
  Fly   587 -KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDG 648

Human   598 WLTKNMDPLNDNVTSLLNASSDKFVADLWKDV--DRIVGLDQMAKMTESSLPSASK----TKKGM 656
            :|.||.|.|..:|..||.:|....|.:|.|.:  .|..|         .:||..|.    |.|..
  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG---------KTLPKGSNGRFVTMKPR 704

Human   657 FRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQG 721
            ..||...:.:.|.:|:.::....|.|||||.||.||.:.::|...||:|||..|:|:.|:|.::|
  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769

Human   722 FPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALE---LDPNLYRIGQSKIFFRTGVLA 783
            :|.|:.||.|.:||..|..:.:.:| ...::.|..:::|:.   ::...|::|.:::|.|..:..
  Fly   770 YPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833

Human   784 HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVI---QRNCAAYLKLRN-----WQ 840
            .||..|..::....::.|...||.|.|:..|:||...|.::..   ||....|.:||.     .:
  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQR 898

Human   841 WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--NELKELEQKHSQLT-----EEKNL 898
            .||       ..|..|:.:::::.....|:.:|..|:|.  .|.|:...:.|||:     .|...
  Fly   899 LWR-------GRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAF 956

Human   899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ--------------QLQ 949
            :..:||..:..:.:...::|        |..:.....:.::..||.||              :||
  Fly   957 IYSKLQGWSPPHGDRHLVKV--------LGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQ 1013

Human   950 AERKKMAQQML--------DLEEQL------------EEEEAARQKLQLEKVTAEA-KIKKLEDE 993
            ..|:.:...:|        |.::.|            :..|.|::||..:.:..:| ..:.|.||
  Fly  1014 PRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDE 1078

Human   994 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN------KHESMISELEVRLKK 1052
            |||.             |..::..|..|..|    |..|.:|..      :..:..|:..:|...
  Fly  1079 ILVQ-------------LCNQVHGLPPNSGE----ATRLWQLLGQCLCCFQPSAAFSKYLMRFVD 1126

Human  1053 EEKSRQELEKLKRKL--------------EGDASDFHEQIADLQA--QIAELKMQLAKKEEELQ- 1100
            :|........|.|:|              .|....|.....:.:|  :..::.:.|...:|..|
  Fly  1127 DEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQT 1191

Human  1101 ------------AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS---ERAARNKAEKQKRD 1150
                        ||||.....:|.:...|.        :.|.|:..||   :......|||   :
  Fly  1192 VAVDSWTSCEEAAALAVSSLGVASRGWTLV--------LDDGQQLTDSCGLDYVMDLIAEK---E 1245

Human  1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE--------ETRSHEAQVQEMRQK 1207
            |.....|.:::|            ||:..:...|.|..|:..        .|.|.:..|...|:
  Fly  1246 LCPAFPAPRSDL------------LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERR- 1297

Human  1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
                     ...|...|:.|   .|::..|:|.:...|:....||||...:.....|...:..:.
  Fly  1298 ---------SSRELLSRSSA---LNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVP 1350

Human  1273 SKCSDGE------RARAELNDKVHKLQN--EVESVTG---MLNEAEGKAIKLAKDVASLSSQLQD 1326
            :.|...|      .:.:.|||:.|..:.  .|...||   ..::..|:....|.. .|.||:..|
  Fly  1351 TDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASH-GSHSSKYAD 1414

Human  1327 -----TQELLQEETRQKLNVSTKLRQLE--EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
                 |:.....:|.:..::::.:|::.  .:.:.:...||:             ..:..|..|.
  Fly  1415 KAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDD-------------LFSPVLDGSL 1466

Human  1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
            .:|.|..|...::..|             .||::..|..:::        :|||.:.|:.....|
  Fly  1467 DELSDARSLAASIRGG-------------SYEQENEAESEID--------DLDDYINDIFQPIPL 1510

Human  1450 VSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKET------KALSLARALEEALEAK 1506
            |.||||...| |||.|..|  .::|| .:|||. |:|..:.:.      :.:.:|..|:: |.:|
  Fly  1511 VQNLEKLTSK-DQLAAIIKGGGVASK-PEERDE-ESEIEDLDDYINELFEPIPVAEGLDK-LTSK 1571

Human  1507 EEL------------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
            |.|            ...:.:|...|:  :..:.:.|..:::.:..:..|::.|.:.....::|.
  Fly  1572 EHLAVSIRGGGSTDSNGADPLLHQLMQ--LPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLL 1634

Human  1560 DELQATE-----------------------------------DAKLRLE------VNMQALK--- 1580
            .:.||.:                                   .:.:|::      |.|::|:
  Fly  1635 AQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPP 1699

Human  1581 -----------------------------------------GQFERDLQARDEQNEEKRRQLQR- 1603
                                                     .|.|...|..::....|.||.||
  Fly  1700 PPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRK 1764

Human  1604 -----QLHEYETE---LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG-------REEAIKQ 1653
                 |.|:..:.   :|.....|..:|.|   :|.:..::|......:.|       |.|....
  Fly  1765 TTPQAQHHQMTSNGGMMESGPGARGASATA---IEWEEFEIESPTPPPMSGQLMRSSIRLETTTT 1826

Human  1654 LRKLQAQMKDFQRELEDARASRDEIFAT--AKENEK------------KAKSLEADLMQLQEDLA 1704
            ........:|..||.:|.......:..|  ||::.:            |.| |.:::.|..|.:.
  Fly  1827 TTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLK-LSSEMRQRLEQVT 1890

Human  1705 AAERAR-------------KQADLEKEELAEELA---SSLSGRNA----LQDEKRRLEARIAQLE 1749
            |....|             |..|..|..|.::|.   :|:||.|:    :.|....:..:|.::|
  Fly  1891 AGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERME 1955

Human  1750 EELE---------------------------------------------------EEQGNMEAMS 1763
            .:|.                                                   |.:.:....|
  Fly  1956 GKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSS 2020

Human  1764 DRVRK----------------ATQQAEQLSN---ELATERSTAQKNESARQQLERQNKELRSKLH 1809
            .:|.|                |.:|.:.:|:   .|....:::....:|.:|.||:....||:..
  Fly  2021 SQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSR 2085

Human  1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874
            :.|...:|.:..  |.:|...:....:.|:|.||::.         ::|.|| .|||.||:..:.
  Fly  2086 DREDYSESVWDR--AEVEGPASGSGSEKEREKRERER---------ERLYEI-RQVERERESHKV 2138

Human  1875 Y-------------------KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
            |                   :|....|.|..:  ....::.|.|.:|.::....::.|||
  Fly  2139 YQPAPPRVIQASMDTTGGHRREDRTGGLATFR--THMAQKYEHERKRKSSASSGMREELD 2196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951	255/694 (37%)
		Actin-binding. /evidence=ECO:0000250	668..690		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	769..783		3/13 (23%)
		Myosin_tail_1	855..1935	CDD:460256	248/1411 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		14/125 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979		10/62 (16%)
		C-terminal	1942..1979
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	255/694 (37%)
		PTZ00121	<828..>943	CDD:173412	28/121 (23%)
		MyTH4	1014..1171	CDD:470587	30/173 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	16/77 (21%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022