Protein Alignment MYH11 and Myo95E

DIOPT Version :10

• Sequence 1: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Sequence 2: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1218
• Identity: 286/1218 - (23%)
• Similarity: 447/1218 - (36%)
• Gaps: 376/1218 - (30%)

Human    89 DMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPH 153
            |...|..|:|.|.::|:.:||....||||.|...|.:|||.|:..:|...|..|..|...::|||
  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPH 73

Human   154 IYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVV-------------------- 198
            ||.:.:.||:|:....|||.:|.||||||||||..|.::.:|..:
  Fly    74 IYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTS 138

Human   199 ------------ASS-------------------------------------------------- 201
                        |||
  Fly   139 SASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRH 203

Human   202 ------------HKGKKDTS--------------------ITQ-------------GPSFA---- 217
                        ||..::.|                    .||             .|.:|
  Fly   204 MREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTV 268

Human   218 YG--------------ELEKQ--------------------------------LLQ--------- 227
            ||              .|||:                                |::
  Fly   269 YGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPE 333

Human   228 ----------------------------------------------------------------- 227
                                                                             
  Fly   334 RERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTC 398

Human   228 ANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFY 292
            |:..|||.|||.|:||:||||:||...|..|..|..:|.:|..|:|||:|.......||.|||||
  Fly   399 ADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFY 463

Human   293 YMIAGAK-EKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEM-FQETVEAMAIMGFSEEEQLSILK 355
            .::.||. :.::|..|......|..|.|    ..|.::|.| |..|..::.::|.|.||..||.:
  Fly   464 QLLLGADLQLLKSLKLYRNVEKYELLRN----TTAMEEDRMNFHYTKRSLDVLGLSCEESNSIFR 524

Human   356 VVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQT 420
            |::.||:|||.:|....|.|         ..:.|.:..:.....|..:|....::..:.:.:|.:
  Fly   525 VIAVVLKLGNFIFVPITNID---------GTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANS 580

Human   421 --KEQADFAVE-----------ALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEI 472
              ..|.|...|           .|.:..|.|||.|::.::|::|..|.|:  ..|.:||..|||.
  Fly   581 TNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQRE--KNLALLDFYGFEA 643

Human   473 FEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPG 537
            .:.|||||..|||:.||:.|.|...:...|||.|.|||:||:.||: .|.:...|||::|:.  |
  Fly   644 LDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDY-FDNESICELIDKPSY--G 705

Human   538 VLALLDEECWFPKATDKSF----VEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAW 598
            :|:|::|    |.......    |::.|   ..||.|....  .:...|.|.|||..|:|:...:
  Fly   706 ILSLINE----PHLNSNDALLLRVQQCC---AGHPNFMTTG--SNSMCFQIRHYASVVNYSIHRF 761

Human   599 LTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQL 663
            |.||.|.|...:::....|....|..|:.:.:                |....|||.  .|:...
  Fly   762 LEKNSDMLPKYISAAFYQSKLSLVQSLFPEGN----------------PRRQVTKKP--STLSSN 808

Human   664 YKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVF 728
            .:.||..|:..:::...::|.||.||..|:..:.|..||..|:|...::..:.:||.|....::.
  Fly   809 IRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLH 873

Human   729 QEFRQRYEILAANAIPKGFMDGKQ--ACILMIKALELDPNLYRIGQSKIFFRT-GVLAHLEEERD 790
            .:|..||::|.:...|. |..|.|  ...|:|:.|.|....:.||...:|.|: ..:..||:.|.
  Fly   874 VKFFHRYKLLNSLTWPH-FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRR 937

Human   791 LKITDVIMAFQAMCRGYLARKAFAK-RQQQLTAMKVIQRNCAAYLKLRNWQWWR------LFTKV 848
            |:|:::.:..|.|.|.|.|||.|.: |..|:.....             |:.||      .||..
  Fly   938 LRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSA-------------WRTWRECRFGIPFTGR 989

Human   849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE----TEL 909
            :.|..:.|...|      |.:..|.::| ....:..:.:.:.|....:.||...|:..    :.|
  Fly   990 RHLWSLYRVARE------EYRSLKYKRQ-VRWAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPL 1047

Human   910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA-- 972
            ..|.......||...:.|..|.|..:..:.............|:|:...::     .::.:|:
  Fly  1048 STEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTARNRMREKVTASII-----FKDRKASYG 1107

Human   973 --------------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
                          |...|.:|:.||.     .|:.:|..|..||:::
  Fly  1108 RSVGHPFVGDYVRLRHNQQWKKICAET-----NDQYVVFADIINKIAR 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951	231/950 (24%)
		Actin-binding. /evidence=ECO:0000250	668..690		6/21 (29%)
		Actin-binding. /evidence=ECO:0000250	769..783		4/14 (29%)
		Myosin_tail_1	855..1935	CDD:460256	29/172 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	46/113 (41%)
		Motor_domain	<403..937	CDD:473979	175/579 (30%)
		Myosin_TH1	1092..1288	CDD:461801	12/69 (17%)