DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH11 and Myo81F

DIOPT Version :10

Sequence 1:NP_001035203.1 Gene:MYH11 / 4629 HGNCID:7569 Length:1979 Species:Homo sapiens
Sequence 2:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster


Alignment Length:2106 Identity:504/2106 - (23%)
Similarity:878/2106 - (41%) Gaps:443/2106 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    89 DMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPH 153
            ||.|::.::|..:..||..||.|.:||||:|...:.|||||.:.|::::.:..|...|..::.||
  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76

Human   154 IYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAY 218
            ::|:|:.||.|::.|..:|:.:.:|||||||||:||.::|||..:.|:               ..
  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITSN---------------VS 126

Human   219 GELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAR 283
            ..:::|:|:||.||||||||||.:||||||||||:::.||....|.|..|..||||:||...|:.
  Fly   127 SWVQQQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSE 191

Human   284 DERTFHIFYYMIAGAKEKM----RSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMG 344
            .||.:||.|.::|..::.:    ...|....|..|...||. ..|....:.:.|.....|..::.
  Fly   192 GERNYHIMYQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNS-EKINMNLESKKFDAVTMAFTVLQ 255

Human   345 FSEEEQLSILKVVSSVLQLGNIVF-KKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRI 408
            ..:.....:.||:||:|.||||.| ..:......:..|..|...:..|:|::..||.:.:|..:|
  Fly   256 IPQFVIDGVFKVISSILWLGNIEFIDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLLIRQI 320

Human   409 KVGRDVVQ-KAQTKEQADFAVE---ALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAG 469
            .|..::.: ..:.||    |:|   |||||.|.::|.|:::::|...: ..:..|.|||:|||.|
  Fly   321 NVRGNITEIPLKIKE----ALENRHALAKALYSKMFTWLVSKINNCTN-PGQDDAKFLGVLDIFG 380

Human   470 FEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNN 534
            ||.|..|||||||||||||||.:.|||.:|.|||..|:.|||.:|.::| .|..||:|::|:|  
  Fly   381 FENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKP-- 442

Human   535 PPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKD-KTEFSIIHYAGKVDYNASAW 598
            |..|..||.|:|..|:.:|.:|:..:.||..|||.:.|....:. :|||.|.||||.|.|....:
  Fly   443 PRCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYAVGGF 507

Human   599 LTKNMDPLNDNVTSLLNASSDKFVADL--WKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVG 661
            :.||.|...|.:...::.|.|.|:.||  ::|:..|          .||.|..|...|   .||.
  Fly   508 VEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQDIQFI----------NSSYPRGSSKSK---CTVS 559

Human   662 QLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRI 726
            ..::.||..|:..|:||.|.:||||.||.:||....::.|||:||:..||::.|||.|:|||..:
  Fly   560 DNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHL 624

Human   727 VFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDL 791
            ..::|..||:.|..|   |.|...::....:::...:....::||:||||.|......||..|..
  Fly   625 SHKDFIVRYKCLIKN---KSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKD 686

Human   792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRN-WQWWRLFTKVKPLLQVT 855
            .:....:..|...:.|..:|:|.:.:|             |.|:::: ::.|||..:   .:::.
  Fly   687 TLYKNAVIIQKNWKKYYIQKSFLRNKQ-------------AVLRIQHAYRGWRLRIR---FMRMR 735

Human   856 RQEEEMQAK-----EDELQKTKERQQKAENELKELEQKHSQLTE--EKNL--LQEQLQAETELYA 911
            |....:|::     ..|:.......::.:.|||:.:..:.|||.  .|.|  .:..:|.|..:.|
  Fly   736 RSAIVIQSRLRGVFAREVAAALREMKRVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLA 800

Human   912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE---EEEAAR 973
            ...: .:|.:||.             |.::.|  ......|..:.|..::|:...:   |.:.|.
  Fly   801 HISD-NIRASAKP-------------LSDKND--SDSNTARSSIKQNTVNLDNMFDFLCESKGAF 849

Human   974 QKLQLEKVTAEAK--IKKLEDEI-LVMDDQNNKLSKE----------RKLLEERIS------DLT 1019
            :...::::.....  :|.|::|| |.:..:::..|::          |.|.|..:.      .::
  Fly   850 ENALIKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSIS 914

Human  1020 TNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADL 1081
            .|| :|...:|.||.||....|         :|||:....:.:.:|  .|....:|.|       
  Fly   915 ANLNSEPIYEAINLYKLTTTKE---------IKKEKYMLLDYKSIKDNSKKPSTSSVF------- 963

Human  1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
                  :|.|:.::|..             :|....|||.||.  :.|:.:|:..:.:..|..|.
  Fly   964 ------VKYQIDERENR-------------RKQRVEKKIHELT--LIDIHKDIHIDNSFYNILEF 1007

Human  1147 QK-----RDLGEELEALKTELE--DTLDSTATQQ------------------------------- 1173
            .:     .||..:...:.|..:  .:.|.||..:                               
  Fly  1008 AENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFR 1072

Human  1174 --------ELRAKREQEVT--VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ--------LE 1220
                    ||.|:||.::.  ::...::.|....|..:|.:||.......:.|::        :.
  Fly  1073 ELCKYMRGELNAERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIV 1137

Human  1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQ------------------AKQEVEHKKKK---- 1263
            .|:.:|.........::|...:|.|:||...|                  :..||...::.    
  Fly  1138 AFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQWCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIV 1202

Human  1264 -----LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG-----MLNEAEG----KAIKLA 1314
                 |:|:.:.:....:|      ...|.|.||..::...|.     ..|..:|    |:....
  Fly  1203 CRFFFLDARTKAIDVHPTD------TAGDAVQKLAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYL 1261

Human  1315 KDVASLSSQLQDTQELLQEETRQKLNVST--------KLRQLEEERNSLQDQLDEEMEAKQNLER 1371
            .||.|.....|.|    ...|::..|.|:        |.|..:......||.::..|...|.:..
  Fly  1262 YDVISSWEMKQAT----YAGTKKTTNGSSSGENQFVFKKRLFKSTHELSQDPVEVSMLYSQAVHS 1322

Human  1372 HISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIEN-----LTQQYEEK------AAA 1421
            .:......:|:    ....||...:..:...:.|..:..:|.:     :::..|::      |.|
  Fly  1323 VVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPEYYSDINSFLPIRISKTREQQFWIPILAQA 1387

Human  1422 YDKLEKTKNRLQQELDDL--------------VVDLDNQRQLVSNLEKKQRKFDQLL---AEEKN 1469
            :.:...::|.|..::..|              .|:......|.||:..... :|.::   .|:|:
  Fly  1388 HRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNYKGYWNLASNIILGIH-YDGIMFINPEDKS 1451

Human  1470 I--SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM--EDLVSS---- 1526
            :  ..||.|    .|:...:.....::::            |.|:.::||..:  ..|:.|    
  Fly  1452 VVFQFKYVD----IESILLDPSDSFITIS------------LNRSAQLLKTSLYGSSLIESQKCF 1500

Human  1527 ------KDDVGKNV------------HELEKSKRALETQMEEMKTQLEELEDELQATEDAKL--R 1571
                  |:|:|..:            :.||.||:...|..          ||.|:..::..|  |
  Fly  1501 VFETPQKNDIGSLIISYYPALSNWILNNLECSKKYKGTTK----------EDRLRLYQNVVLCRR 1555

Human  1572 LEVNMQALK-----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ---------RALA 1622
            ..|:|..:|     |.|.|:         ..||..:.:|.:..:|:....::         ....
  Fly  1556 HLVDMNIVKKPHDFGGFLRN---------TLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTFW 1611

Human  1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD-------FQRELEDARASRDE--- 1677
            |.:|:::...:        |.|..:|||      |..|:.|       .....|....:.||   
  Fly  1612 AFSKQQIPFCI--------STISDQEEA------LMIQVFDSILTYSGLGSSGESISRAEDEHIR 1662

Human  1678 IFATAKENEKKAKSLEADL-MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
            |..:..:...|.:||..:| :||.:.......|..:.:|:...|...|.|.:  ..:::..::.|
  Fly  1663 IIQSIMDKCMKKESLLNELYLQLIKQTTDHPDANSRVNLKNWALLSVLCSVI--LPSMKAVRKYL 1725

Human  1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE-LR 1805
            .|.:.:...:...|:|.....::.....||         .|.|  .|...|..:.|...|:. ..
  Fly  1726 IAHLKRCSSDFLSEEGKYARYAENCFFRTQ---------GTRR--RQWTPSREEILCTTNRRPCY 1779

Human  1806 SKLHEMEGAVKS-KFKSTIAA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
            ||.:.|:|...| :|:.:..|      ::.||..|:........|....::.....::|:.:::.
  Fly  1780 SKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLDNAKGYSIYEVIGNSERSLSSEEKVCDVMA 1844

Human  1864 QVEDERKMAEQYKEQAEKGNARVKQLKR---------------QLEEAEEESQRINANRRKLQRE 1913
            :.|..:..::|   ..:|....:.|..:               .||:..|:....:.....|:.|
  Fly  1845 KWEKYQITSQQ---GFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVEKELLYHQILHNLRSE 1906

Human  1914 LDEATESNEAMGREVNALKSKLRRGN 1939
            ....||....|   :.||:|:|.||:
  Fly  1907 RYPITEMEAIM---LTALQSQLERGD 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH11NP_001035203.1 Myosin_N 31..76 CDD:460670
MYSc_class_II 99..778 CDD:276951 254/690 (37%)
Actin-binding. /evidence=ECO:0000250 668..690 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 769..783 7/13 (54%)
Myosin_tail_1 855..1935 CDD:460256 229/1321 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..889 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1807 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1873..1979 17/82 (21%)
C-terminal 1942..1979
Myo81FNP_001303492.1 Motor_domain 23..673 CDD:473979 254/689 (37%)
MyTH4 1091..1194 CDD:459939 16/102 (16%)
FERM_F1_DdMyo7_like 1198..1299 CDD:340728 21/110 (19%)
B41 1202..1419 CDD:214604 36/226 (16%)
PH-like 1415..1523 CDD:473070 20/124 (16%)
MyTH4 1664..1771 CDD:459939 21/119 (18%)
FERM_F1_DdMyo7_like 1775..1880 CDD:340728 16/107 (15%)
B41 1781..1992 CDD:214604 29/155 (19%)
PH-like 1988..2076 CDD:473070
Blue background indicates that the domain is not in the aligned region.

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