DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH10 and didum

DIOPT Version :9

Sequence 1:XP_011522177.1 Gene:MYH10 / 4628 HGNCID:7568 Length:2037 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2004 Identity:547/2004 - (27%)
Similarity:890/2004 - (44%) Gaps:412/2004 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    66 VWIPSERHGFEAASIKE--ERGDEVMVELAENGK----KAMVNKDDIQKM-NPPKFSKVEDMAEL 123
            :|:|.....:|:|:::|  .:|...:....::||    |...:..|:..: ||.......|:..|
  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78

Human   124 TCLNEASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAI 187
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|..:||..|||....::.|||:|:
  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143

Human   188 SESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQESPKPVKHQG 252
            :|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|                 :.:.
  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-----------------ESET 191

Human   253 ELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEKSRAVRQ 314
            ::||::|.::||:|:||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.|.|
  Fly   192 QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQ 256

Human   315 AKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIP-IPGQQDKDNFQETMEAMHIMGF 378
            |:.||.:||||||.:...::  .:|:|:..:.::||:.|..| |....|.:.|.||::||.::||
  Fly   257 AQGERNYHIFYQLCAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGF 319

Human   379 SHEEILSMLKVVSSVLQFGNISFKK-------ERNTDQASMPENTV-AQKLCHLLGMNVMEFTRA 435
            |.::|..::|:::.:|..|||...|       |.::|...:..|.: .|....||.::..:..|.
  Fly   320 SIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRW 384

Human   436 ILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDI 500
            :|..:|:...:||....:.|.|..|.:||||..|.:||:::|..:||:|:...:| .||||:|||
  Fly   385 LLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDI 448

Human   501 AGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERP 565
            .|||.||:|||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||  
  Fly   449 YGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE-- 510

Human   566 ANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADE 630
             :..|||.||||||..||.:|:::..||:.:......|:|||  .....|.|.|::..|:|..:.
  Fly   511 -SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNG 572

Human   631 WLMKNMDPLNDNVATLLHQSSDRFVAELWK-DEIQNIQRASFYDSVSGLHEPPVDRIV---GLDQ 691
            :|.||.|.::..:..:|.:|:.....::.. :||..:...|...|..|      .|:|   |..|
  Fly   573 FLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLG------GRVVISAGRKQ 631

Human   692 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 756
            ....|......:.:.:|    |||..::|||..|::||..|.|::||||.||.:|.|.|.:...:
  Fly   632 QGNDTRRRVVPSKQHRK----TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKI 692

Human   757 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT-PNAIPKGFMDGKQACERMIRALELDPN 820
            :.|||..||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:
  Fly   693 IQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDED 755

Human   821 LYRIGQSKIFFRAGVLAHLEEERD-----------------------LKITDIIIFFQAVCRGYL 862
            .||.|.::||||||.:|.||:.|.                       |:|..:|...|...||||
  Fly   756 KYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYL 820

Human   863 ARKAFAKKQQQLSALKVLQRNCAA------YLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEE 921
            ||:...|.::..:.| :|.:....      ||:|||     ..:.::...:......:..|..:.
  Fly   821 ARERTQKMREARAGL-ILSKYARGWLCRRRYLRLRH-----SISGIQTYARGMLARNKFHAMRDH 879

Human   922 LLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 986
            ...| :.|..|.|.|  ..|.:|:  ..:||:.  .||....|.    .|.:....|.|.:.|.|
  Fly   880 YRAV-QIQRFVRGAL--ARRAYQK--RRRNIII--CQAAIRRFL----ARRKFKRMKAEAKTISH 933

Human   987 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 1051
                           ::|:...::..|..:::::||..  |....|:..|:|..:.||:.|:...
  Fly   934 ---------------MENKYMGLENKIISMQQRIDELN--RDNSNLKHKTSEISVLKMKLELKKT 981

Human  1052 EDQNSKFIKEKKLMEDRIAEC-SSQL-AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1114
            .:...|.:|.....:|::.|. :.|| ||.:||.:.|.:..:.||..||       :::..|||.
  Fly   982 LEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWIS-------QKQTWRQEN 1039

Human  1115 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1179
            |                  ||:.||||: :.:||..|..|            :|...:::.|:..
  Fly  1040 E------------------ELRRQIDEI-IDMAKNAEVNQ------------RNQEDRMLAEIDN 1073

Human  1180 QIAELQEDFESEKASRNKAEKQKRDLSEELEAL---------------KTELEDTLDTTAAQQEL 1229
            :  ||.|.::.....:...|.:...|.|||..|               .::.||.:...:|:..|
  Fly  1074 R--ELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL 1136

Human  1230 RTKREQE--------------VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQ-LEQAKRF 1279
            ...|..:              |.:|:..||||.:.|:.               |.|| ::.:.|.
  Fly  1137 DINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKV---------------LQEQYIKLSSRH 1186

Human  1280 KANLEKNK-QGLETDNKELACEVKVLQQVKAESEH--KRKKLDAQVQELHAKVSEGDRLRVELAE 1341
            |...:..: ..||.:|::|..|   ..|::...:|  :..:|:||    ||.:.|..|.|   .|
  Fly  1187 KPTEDSFRVSELEVENEKLRSE---YDQLRTSIKHGVEINELNAQ----HAALQEEVRRR---RE 1241

Human  1342 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL---NLSSRIRQLE 1403
            :..:|:      :.||::::...   :.:..||:.:..|..||::....|||   .|.|.::.:.
  Fly  1242 ECIQLK------AVLLQQSQSMR---SLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAIT 1297

Human  1404 EEKNS-LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1467
            ||.|| |.|..:|.|  |.|.||          |..:||..:  :|:..|::....|:..:...:
  Fly  1298 EEHNSKLVEMTQEIE--RLNNEK----------DELQKVMFE--SIDEFEDSNVDTLRQNDRYLR 1348

Human  1468 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1532
            |..:||:|...|      :|:||......|...||....||.|        .||:.|  |.....
  Fly  1349 RELQKAVAQFLL------VQEELKLANAKLKAYRQDGGQLEHK--------IEEEMI--RNKSNG 1397

Human  1533 DRAEAEAREKETKALS-----------LARALEEALEAKEE---------FERQNKQLRADMEDL 1577
            ..|:..|...:.|:.:           |.:.|:..|.|...         |......:.....||
  Fly  1398 TSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDL 1462

Human  1578 MSSKDDV----GKNVHELEKSKRA---LEQQV---EEMRTQLEELEDELQATEDAKLRLE-VNMQ 1631
            .::.|||    .|.|.:::|..|.   :|.:|   ....|.|..::......|..|...| .|.|
  Fly  1463 TNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQ 1527

Human  1632 AMK----AQFER---DLQTRDEQNEEKKRLLIKQVREL------EAELEDERKQRALAVASKKKM 1683
            .:|    .::.|   ||.....|      .||.|::.|      .|.|.::..||.......:..
  Fly  1528 QLKNFNLFEYRRVILDLIVNLYQ------ALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSR 1586

Human  1684 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ------------- 1735
            ...:....:.......|..::|.||.....|.:.:  .|:...|  ::||.|             
  Fly  1587 ATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHF--GLDNCYA--EQIFHQLLYFICAVALNCL 1647

Human  1736 ---------------------------SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1773
                                       ||:....:.:..|.:.|:.:.|.|     |.:||:...
  Fly  1648 MLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQS-----RKSEQDVQT 1707

Human  1774 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1838
            :.|..|:.::             |::.::.:..:.:....|:.|....|.|   :.|||      
  Fly  1708 ICDLCTSLST-------------AQVLKVMKSYKLDDYESEITNVFLEKLT---EKLNA------ 1750

Human  1839 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSK----FKATISALEAKIGQLE 1888
                      :|:::.|.:        |..:..|    ||......:.|:..:|
  Fly  1751 ----------RQMQKSNSD--------EFTIDQKFIQPFKVVFRYSDIKLEDIE 1786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH10XP_011522177.1 Myosin_N 64..102 CDD:280832 9/41 (22%)
Myosin_head 117..832 CDD:278492 282/732 (39%)
MYSc_Myh10 129..832 CDD:276952 278/720 (39%)
Myosin_tail_1 909..1989 CDD:279860 227/1107 (21%)
DUF342 <1105..1194 CDD:302792 19/88 (22%)
DUF2317 <1172..1283 CDD:302887 27/140 (19%)
COG5134 <1399..1527 CDD:227463 35/128 (27%)
GBP_C <1565..1671 CDD:303769 29/129 (22%)
coiled coil 1661..1671 CDD:293879 3/15 (20%)
DUF106 <1706..>1757 CDD:303007 12/90 (13%)
DUF2570 1834..>1928 CDD:305162 8/59 (14%)
didumNP_724569.1 MYSc 65..778 CDD:214580 291/750 (39%)
MYSc_Myo5 84..767 CDD:276831 278/720 (39%)
IQ 900..922 CDD:197470 6/29 (21%)
GBP_C <971..1086 CDD:303769 37/154 (24%)
coiled coil 1049..1068 CDD:293879 5/31 (16%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 29/127 (23%)
Myo5_CBD 1424..1792 CDD:271254 73/418 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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