DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH10 and ck

DIOPT Version :9

Sequence 1:XP_011522177.1 Gene:MYH10 / 4628 HGNCID:7568 Length:2037 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2217 Identity:551/2217 - (24%)
Similarity:933/2217 - (42%) Gaps:509/2217 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    56 TQADWTAKKLVWI-PSERHGFEAA-------------SIKEERGDEVMVELAENGKKAMVNKDDI 106
            |:.|:     :|| |:....|:.|             .::::.||||.  ||...:        |
  Fly     5 TRGDY-----IWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVW--LAPERR--------I 54

Human   107 QKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEM 171
            :.|:......||||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.|::
  Fly    55 KAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKL 119

Human   172 YRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRK 236
            |:.:|..|:||||:||.::||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..  
  Fly   120 YKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW-- 182

Human   237 DHNIPQESPKPVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI 301
                             :|:|:|:||||||:||||||::|||||||||:|.|:|...|.|.||.|
  Fly   183 -----------------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKI 230

Human   302 ETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNG-YIPIPGQQDKDN 365
            |.|||||||.|.|...||.:|:||.:|:|.....||.|.|....:|::|:.| .|...|:.|...
  Fly   231 EQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAE 295

Human   366 FQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKE--RNTDQASMPENTVAQKLCHLLGMN 428
            |.:...||.::.||.:||..::|:::::|..|||.:|..  .|.|...:||:...:::..|||:.
  Fly   296 FSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLP 360

Human   429 VMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGAS 493
            :.....|:....:....:.|....:::|:....:|..|..|.|:|..:|.:||.|:.:.:....:
  Fly   361 IQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN 425

Human   494 FIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 558
            .||:|||.|||.|:.|||||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..
  Fly   426 AIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDA 489

Human   559 IDLIE-RPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKAD----FCII 618
            :|||. :..|   ::||:|||..|||.||:|.:.||.:..|||..:.||     |:|    |.:.
  Fly   490 LDLIAIKQLN---IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKP-----KSDINTSFGLN 546

Human   619 HYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPV 683
            |:||.|.|....:|.||.|..:.::..|:.||:::|:.:::..:|:                   
  Fly   547 HFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIE------------------- 592

Human   684 DRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRA 748
                            .|:  :|:| ...|:...:::||..||.||.:..|.|:|||.||..|:.
  Fly   593 ----------------MGA--ETRK-RTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKP 638

Human   749 GKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIR 813
            ...|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|.......||....|.
  Fly   639 MMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRIC 702

Human   814 ALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK 878
            |:.|..:.|::|.:|:|.:......||:|||..:|..|:..|...||::.|:.|.:.:   :|..
  Fly   703 AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLR---AAAI 764

Human   879 VLQRNCAAYLKLRHWQWWRV-FTKVKPLLQ---VTRQEEELQAKDEELLKVKEKQTKVEGELEEM 939
            .:||....|.:.:.::..|| :.:::.|::   ::.:...|:.      .:...|....|.|...
  Fly   765 TVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRG------HIVGLQAHARGYLVRR 823

Human   940 ERKHQQLL------EEKNILA----EQLQAETELFAEAEEMRARLAAKKQELEEILH--DLESR- 991
            |..|:...      ..:.::|    .:|:.|.:.|||..::|      |.|.:|:||  :..:| 
  Fly   824 EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLR------KLEEQELLHRGNKHARE 882

Human   992 VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 1056
            :.|:..|:::.:.|::::|       |||:.    |:::::.........:|.||.:     .:.
  Fly   883 IAEQHYRDRLHELERREIQ-------EQLEN----RRRVEVNMNIINDAARKQEEPV-----DDG 931

Human  1057 KFIKEKKLMEDRIAECSSQL-----AEEEEKAKNLAKIRN-KQEVMISDLEERLKKEEKTRQELE 1115
            |.:   :.|.|.:.:.||..     ..|.....:|...:| .|:.:|:.:.....:|:.:..:.:
  Fly   932 KLV---EAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQ 993

Human  1116 K--------------AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1166
            |              ||:.|......|..|..:|.||  .|.:.:.:    ..|.:......|:.
  Fly   994 KFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQ--ALWITILR----FTGDMPEPKYHTMD 1052

Human  1167 KNNALKVVREL---------------QAQIAELQEDF---ESEKASRNK----AEKQKRDLSEEL 1209
            :.:...|:.::               :||:..|..|.   :..::.|:|    ..|:|..|.|::
  Fly  1053 RMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDV 1117

Human  1210 EALKTELEDTLDTTAAQQELRTKREQEV-----------AELKKAL-----EEETKNHEAQIQDM 1258
            .....:.|.|.|:..:..:.|.....|.           |||:..:     ::.|.|      .:
  Fly  1118 RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN------PL 1176

Human  1259 RQRHATALEEL---------SEQL--------------------EQAKRFKANLEKNK--QGLE- 1291
            :..||.....|         ||:.                    |:.||...|..:|:  ..|| 
  Fly  1177 KSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL 1241

Human  1292 ---TDNKELACEVKVL----QQVKAESEHKRKKLDAQVQELHAKVSEGDR----LRVELAEKASK 1345
               ...|.:...:..:    :.:.|:|....::|..|:.:   |:|..|:    |.:.|.:|.|.
  Fly  1242 QATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSD---KISLKDQFGFSLYIALFDKVSS 1303

Human  1346 LQNELDNVSTLLEEAEKKGIKFAKDAASLES----QLQDTQELL---QEETRQKLNLSSRIRQL- 1402
            |.:..|:|...:.:.|    ::||:..:.|.    :|...:|:.   .|.|..::..:...:|: 
  Fly  1304 LGSGGDHVMDAISQCE----QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVV 1364

Human  1403 ------------EEEKNSLQEQQE-EEEEARKNLEKQVLALQSQLAD-----TKKKVDDDLGTIE 1449
                        ||:...:..||. .|.....::|:....|.:.:.|     ..|.::.....: 
  Fly  1365 RGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV- 1428

Human  1450 SLEEAKKKLLKDAEALSQRLEEKALAYDK----------LEKTKNR------------------- 1485
             |:..||......:....:::|..::|.|          .|..:|.                   
  Fly  1429 -LQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVY 1492

Human  1486 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA------EEKSISARYAEE-RDRA-----EAE 1538
            :..:.:.:.::|......|.:.:|..|.|.|..:      ||.:..:..||: ||..     ..:
  Fly  1493 VVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLK 1557

Human  1539 AREKETKALSLARALEEALEAKEEFER------------------------QNKQLRAD------ 1573
            .|.|...||...||..:.......|:.                        ...|.|.|      
  Fly  1558 KRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETV 1622

Human  1574 --MEDLMSSKDDVGK--NVHELEKSKR--------ALEQQVEEMRTQLEELEDELQ--------- 1617
              :..|.....|:..  |:.|....:|        |:|.: :...|.:|...|..:         
  Fly  1623 YVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR-DRPHTLMEYALDHFRLPPKRTMSK 1686

Human  1618 -ATEDAKLRLEV---NMQAMKAQFERDLQTRDEQNEE---KKRLLIKQVRELEAELEDERKQRAL 1675
             .|..:|...|:   :...:||...|.||:::|..||   ....::|.:.:|.::          
  Fly  1687 TLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSK---------- 1741

Human  1676 AVASKKKMEIDLKD------LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA-----SR 1729
                :.:|..::.|      |:.:|     .|||:..||.|   |:.|.:..:.|.|.     ..
  Fly  1742 ----RPRMGNEITDHIFDGPLKHEI-----LRDEIYCQLMK---QLTDNRNRMSEERGWELMWLA 1794

Human  1730 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1794
            ..:||.|:              .|.:||....|.|||...:                   |...|
  Fly  1795 TGLFACSQ--------------GLLKELLLFLRTRRHPISQ-------------------DSMHR 1826

Human  1795 LEARIAQLEEELEEEQSNMELLNDR----FRKTTLQVDTLNA-ELAAERSAAQKSDNARQQLERQ 1854
            |:..|...:.:....|..:|.:..:    |.|.....||..| |:.:...|....:|..|:|..:
  Fly  1827 LQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLR 1891

Human  1855 NKE---LKAKLQELEGAVKSKFKATISALEAK-----IGQLEEQLEQEAKERAAANKLVRRTEKK 1911
            ..|   |..|:.:          ..||..|..     :..|.:.:::....|..||.........
  Fly  1892 TSEGFSLFVKIAD----------KVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFF 1946

Human  1912 LKEIFMQ-VEDERRHAD---QYKEQMEKANARMKQLKRQLEEAEEEA-----TRANASRRKLQ-- 1965
            :|:::.. |..:.|:||   .|.:::.|......:..|  |||.:.|     .|...::::||  
  Fly  1947 MKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSR--EEAAKLAALVFRVRFGENKQELQAI 2009

Human  1966 ----REL 1968
                |||
  Fly  2010 PQMLREL 2016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH10XP_011522177.1 Myosin_N 64..102 CDD:280832 11/51 (22%)
Myosin_head 117..832 CDD:278492 277/722 (38%)
MYSc_Myh10 129..832 CDD:276952 270/710 (38%)
Myosin_tail_1 909..1989 CDD:279860 240/1338 (18%)
DUF342 <1105..1194 CDD:302792 18/120 (15%)
DUF2317 <1172..1283 CDD:302887 29/177 (16%)
COG5134 <1399..1527 CDD:227463 26/181 (14%)
GBP_C <1565..1671 CDD:303769 26/163 (16%)
coiled coil 1661..1671 CDD:293879 1/9 (11%)
DUF106 <1706..>1757 CDD:303007 11/55 (20%)
DUF2570 1834..>1928 CDD:305162 19/105 (18%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 280/735 (38%)
MYSc_Myo7 77..721 CDD:276832 270/710 (38%)
MyTH4 <1138..1245 CDD:214535 19/112 (17%)
B41 1251..1467 CDD:214604 38/224 (17%)
FERM_B-lobe 1355..1439 CDD:271216 13/85 (15%)
FERM_C1_MyoVII 1461..1559 CDD:270019 14/97 (14%)
SH3 1560..1624 CDD:302595 9/63 (14%)
MyTH4 1701..1849 CDD:214535 40/202 (20%)
B41 1856..2068 CDD:214604 38/173 (22%)
FERM_M 1966..2068 CDD:278785 13/53 (25%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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