Protein Alignment MYH9 and MYO1

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 2068
• Identity: 619/2068 - (29%)
• Similarity: 1058/2068 - (51%)
• Gaps: 363/2068 - (17%)

Human    27 AAKKLVWVPSDKSGFEPASL-------------KEEVGEEAIVELVENGKKVKVNKDDIQKMNPP 78
            ::..:||:|.:|..|....|             :|::|....::..|....|:|...|:..:||.
Yeast     8 SSNMIVWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPS 72

Human    79 KFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGK-- 141
            .|.|||:|:|||.|||.|||:||::||...|||||||||.|.||||.||.:|||:.:.:|..|
Yeast    73 TFDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHN 137

Human   142 ---------KRHE-MPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVAS 196
                     ..|| :||||:||.:.||.:::.:.:|||||.||||||||||||||::||||.:.|
Yeast   138 RLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITS 202

Human   197 SHKS-------KKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANI 254
            ...|       .......|.::||:|||||:||||:||:|:|||||||||:|.|:.:|.|.||:|
Yeast   203 GSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHI 267

Human   255 ETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYN--KYRFLSNGHV-TIPGQQDK 316
            |.|||||||.:.|..:||.:||||.||||..:....:|.|:..|  .|:.|||.:. .|||..|.
Yeast   268 EWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDV 332

Human   317 DMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGIN 381
            :.|:|.:.|:.|:|..:::...:.:|::.:|.:|||.|..:| .:|||..::.:|  :...||::
Yeast   333 ENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDR-AEQASFKNDVSA--ICSNLGVD 394

Human   382 VTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGA- 445
            ..||...||.||.|.|:::|.:::..:||.|.:.||::..|||:|.::|..|||.||    .|:
Yeast   395 EKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLD----HGSA 455

Human   446 --SFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDL 508
              ::||:|||||||||:.|||||||||||||||||.||:.||:|||.||.:|.|:|::||:|.||
Yeast   456 TLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDL 520

Human   509 QPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHY 573
            |..|||||....|.|:|.|||||...||:||:||..|::.....:....|..:||:  .|.:.||
Yeast   521 QLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKN--GFILKHY 583

Human   574 AGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWK---DVDRIIGLDQVAGMSETALPGA 635
            ||.|:|..:.||.||.||||||:.:||..|.:..:|:|::   :.....|::  |.:|...:..:
Yeast   584 AGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVE--ANISNQEVKKS 646

Human   636 FKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEG 700
            .:|  ..|:|....::||...|:..|.:|:|:||||||||:.||....:..|:||||||||||||
Yeast   647 ART--STFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEG 709

Human   701 IRICRQGFPNRVVFQEFRQRYEILTP-NSIPKGF-----MDGKQACVLMIKALELDSNLYRIGQS 759
            ||:.|:|:|||:.||||.|||.||.| ||....|     ...||.|..::.:|:||:.:|:||.:
Yeast   710 IRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNT 774

Human   760 KVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKL-R 823
            |:||:|||||.||:::|:|:.:::|...|..|||..||......|:|...:|:......|.:| :
Yeast   775 KLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVK 839

Human   824 NWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ---- 884
            ...|:.||.::||||..|..........|::.|::       |.|.|||: :.:.:.||.|
Yeast   840 EDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLK-------NDLQEMES-KKKFLEEKNQKTVN 896

Human   885 ----LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI 945
                .|:.|..|.|...:.|.|..|:....:.|::...||   |.|::|    :..||.::.||:
Yeast   897 ELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDL---VSEKDE----ISREKLEVAQNL 954

Human   946 QELEEQLEE-EESARQKLQLEKVTTEAKLKKL--EEEQII--LEDQNCKLAKEKKLLEDRIAEFT 1005
            :|..::::. :|:.|::        ||.|:||  :..::|  :.|.||.::|
Yeast   955 EEAHQKIQGLQETIRER--------EATLEKLHSKNNELIKQISDLNCDISK------------- 998

Human  1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
                  |:.|:||.|                           :::.|||.:...|.|.|...:.:
Yeast   999 ------EQSSQSLIK---------------------------ESKLKLENEIKRLKDVINSKEEE 1030

Human  1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
            |.....:|:..||:|...|..:|:..   |:|:.:::.|.::.|:|       |:.....:|:|.
Yeast  1031 IKSFNDKLSSSEEDLDIKLVTLEKNC---NIAMSRLQSLVTENSDL-------RSKNENFKKEKA 1085

Human  1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200
            .|..:|:..::||              .|.:::::..||.|...:|..:..:.|    |.:...|
Yeast  1086 ALNNQLKNKESEL--------------LKMKEKIDNHKKELATFSKQRDDAVSE----HGKITAE 1132

Human  1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVK----VLLQGKGDSEHKRKKVEAQLQELQVKF 1261
            |.|...|....|:|.:|.|:...|.:.|...:.:    .|::...||  |.|::||:|.: ::..
Yeast  1133 LKETRIQLTEYKSNYQKIKEEYSNFQRETKEQEQKKRNSLVESLNDS--KIKELEARLSQ-EISL 1194

Human  1262 NE-------GERVRTELA-------------DK----------------VTK-LQVELDNVTGLL 1289
            |:       |..|.|.::             ||                :|: |:.|::....|:
Yeast  1195 NQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLI 1259

Human  1290 SQ---SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED--------------E 1337
            |:   ::::.:..:.:...:::|::..::|:|:.: ..:.|.:.|.:..|              |
Yeast  1260 SRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMD-PSIPLDSILNEPLDNCPDKESDINKLMLE 1323

Human  1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC-------LETAEEVKRKLQKDLE 1395
            .:..:.||:.|..|.::.|..|:.||::.  .|.:.|.|:..       .|.:||..:.|:..|:
Yeast  1324 VDYLKRQLDIETRAHYDAENAISALHSKF--RKIQGESSLSSSDIYKLKFEASEERVKSLEDKLK 1386

Human  1396 GLSQR-------------------HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
            .:..|                   :||::..| |||..|  ||:.|::     .:.:.|...|:.
Yeast  1387 TMPLRDRTNLPVGDIIKNRDSISKYEEEIRYY-KLENYK--LQEILNE-----SNGKLSQLTLDL 1443

Human  1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
            :|.|..:.|..|:.       :|.:.:.|:.|::.:.||            :.:::..:||...|
Yeast  1444 RQSKSKEALLSEQL-------DRLQKDLESTERQKELLS------------STIKQQKQQFENCM 1489

Human  1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
            :||..::..:.:.:|.|:::    |:.|:.|.:.:|:|:.:             |.|..|..:||
Yeast  1490 DDLQGNELRLREHIHALKQA----EEDVKNMASIIEKLKTQ-------------NKQKEKLIWER 1537

Human  1572 DLQGRDEQSEEKKKQL-VRQVREMEAELEDE---RKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
            :::..|...:.::..| :::|::::..|.|:   .|:|..||..|.:...::..|:..::.:.|.
Yeast  1538 EMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKA 1602

Human  1633 RDEAIKQLRKL-----------QAQMKDCMRELDD-TRA------SREEILAQAKENEKKLKSME 1679
            .....|:...|           :|::.|.:::||. |:.      .::.|....||..:|.:::.
Yeast  1603 ETNLKKEFATLKYKLETSTNDSEAKISDLLKQLDHYTKVVEMLNNEKDAISLAEKELYQKYEALN 1667

Human  1680 AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE----ELEE 1740
            .|...|:.::.:..:.|::.:.:.::..|.:..|:...:.:.::.:.:..:|..|||    ::|:
Yeast  1668 TECESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSSTQKNKEITEKIKYLEETLQLQMEQ 1732

Human  1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN-----ENARQQLERQNKELKVKLQEM--- 1797
            ...|.||:.......|...|:.:.:       .|||     ||  |.|::.|.:|:::|:.:
Yeast  1733 NSRNGELVKTLQASCNGYKDKFDDE-------KQKNIDLYEEN--QTLQKLNTDLQLQLKNLHER 1788

Human  1798 --EGTVKSKYKASITALEAKIA-----QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855
              :.|.|:.:.:.|..||..::     :.||...|::.||  |.::::....:..||   ::...
Yeast  1789 LSDTTEKNAWLSKIHELENMVSLETDLKYEEMKKNKSLER--AVEELQTKNSQQTDV---IELAN 1848

Human  1856 RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ---RANASRRKLQRELEDATE 1905
            :|..::::...|...::..|::.:.:.|.|.:   |.|:|.|...:|:....|
Yeast  1849 KNRSEFEEATLKYEAQISDLEKYISQQELEMKKSIRDNSSYRDKVQEMAQEIE 1901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		376/858 (44%)
		Myosin_N	27..72	CDD:460670	11/57 (19%)
		Motor_domain	95..764	CDD:473979	324/702 (46%)
		Actin-binding	654..676		11/21 (52%)
		Myosin_tail_1	841..1921	CDD:460256	241/1206 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960		8/32 (25%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	573/1842 (31%)
		Smc	1607..>1901	CDD:440809	59/307 (19%)