Protein Alignment MYH9 and myh9b

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_001427874.1
• Gene: myh9b / 561431
• ZFINID: ZDB-GENE-030131-998
• Length: 1960
• Species: Danio rerio
• Alignment Length: 1959
• Identity: 1602/1959 - (81%)
• Similarity: 1782/1959 - (90%)
• Gaps: 11/1959 - (0%)

Human     7 DKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDD 71
            ||:||||:|.:||||||||||.||||||||::.|||..|||||.|:|.:|||.::|||::|||||
Zfish     5 DKFLYVDRNLVNNPLAQADWATKKLVWVPSERLGFEAGSLKEEHGDEVVVELADSGKKIRVNKDD 69

Human    72 IQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVE 136
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
Zfish    70 IQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVD 134

Human   137 MYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSK 201
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||:|
Zfish   135 MYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKTK 199

Human   202 KDQ-------GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLL 259
            |||       ||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   200 KDQSSSVLSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLL 264

Human   260 EKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETME 324
            ||||||||||||||||:|||:|:|.|:.|:::|.||.||||||||||:||||||||:||:.||:|
Zfish   265 EKSRAIRQAKEERTFHMFYYMLTGVGDKLRSELCLEGYNKYRFLSNGNVTIPGQQDRDMYVETVE 329

Human   325 AMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGI 389
            ||||||..|||.:|||||||.||||||:.|||||::|||||||:||||||.||:|:|||||||.|
Zfish   330 AMRIMGFSEEEHVGLLRVISSVLQLGNMSFKKERHSDQASMPDDTAAQKVCHLMGMNVTDFTRAI 394

Human   390 LTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIA 454
            |:|||||||||||||||:|||:||:||||||||||||||||:|||||||||||||||||||||||
Zfish   395 LSPRIKVGRDYVQKAQTQEQAEFAVEALAKATYERMFRWLVMRINKALDKTKRQGASFIGILDIA 459

Human   455 GFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPA 519
            |||||:|||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
Zfish   460 GFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPA 524

Human   520 GPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEW 584
            .||||||||||||||||||||||||||:|||||||||.|||:|||:|||||||||||||||||||
Zfish   525 SPPGILALLDEECWFPKATDKSFVEKVLQEQGTHPKFHKPKKLKDEADFCIIHYAGKVDYKADEW 589

Human   585 LMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQL 649
            |||||||||||:||||:||:|:||||||||||||:|||:||||||  ||||||||||||||||||
Zfish   590 LMKNMDPLNDNVATLLNQSTDRFVSELWKDVDRIVGLDKVAGMSE--LPGAFKTRKGMFRTVGQL 652

Human   650 YKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVF 714
            |||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
Zfish   653 YKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVF 717

Human   715 QEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKI 779
            ||||||||||||||||||||||||||:|||:|||||.|||||||||||||||||||||||||:||
Zfish   718 QEFRQRYEILTPNSIPKGFMDGKQACMLMIRALELDPNLYRIGQSKVFFRAGVLAHLEEERDMKI 782

Human   780 TDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQE 844
            |||||.|||.||||:|||||||||||||||:|:||||||||||||||||||||||||||||||||
Zfish   783 TDVIINFQAWCRGYVARKAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQE 847

Human   845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
            |||.||||||.||||||..||.:|.|||..|.||.|||:.||||||||.:|||||:|:|.||.||
Zfish   848 EEMQAKEEELSKVREKQQVAEQQLVEMEVKQQQLNAEKMALQEQLQAEMDLCAEADEMRNRLVAK 912

Human   910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK 974
            |||||||.|||||||||||||..|||||||||||||.:||:||:|||:|||||||||||.|||||
Zfish   913 KQELEEILHDLEARVEEEEERANHLQAEKKKMQQNIADLEQQLDEEEAARQKLQLEKVTMEAKLK 977

Human   975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
            |.|||.::|:|||.||:|||||:|:|||||||||.|||||||||.||||||||||||||:|||||
Zfish   978 KTEEEVMVLDDQNNKLSKEKKLMEERIAEFTTNLAEEEEKSKSLQKLKNKHEAMITDLEDRLRRE 1042

Human  1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104
            |||||||||.|||||||||:|.||||||||||||||.||||||||||.||||:||||||||:|.|
Zfish  1043 EKQRQELEKNRRKLEGDSTELHDQIAELQAQIAELKAQLAKKEEELQEALARIEEEAAQKNLAQK 1107

Human  1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV 1169
            ||||||||:||||||||.|||:|.||||.:||||||||||||||||||||||||||||:|||.||
Zfish  1108 KIRELESQLSELQEDLELERAARTKAEKHRRDLGEELEALKTELEDTLDSTAAQQELRTKRETEV 1172

Human  1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
            ..|||.|||:||.||..:.|:|||||||.:||.|||||.||.|.::||:||.||:||.||..|::
Zfish  1173 AQLKKALEEDAKVHEQVMAEIRQKHSQAFDELNEQLEQVKRNKVSVEKSKQALESERNELQIELQ 1237

Human  1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299
            .|:||||:|||:|||.||||||||||..|.||.|.|||:::||:|.|||||..|||.::.||.|.
Zfish  1238 TLMQGKGESEHRRKKAEAQLQELQVKHTESERQRIELAERLTKMQAELDNVNTLLSDAEGKSIKA 1302

Human  1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
            :||.|.:||||||.||:||||.||||||:|:|:|:|||::|.|||||||||||.||||||.|:.|
Zfish  1303 SKDCSTVESQLQDVQEVLQEETRQKLSLNTRLRQLEDEQHSLREQLEEEEEAKRNLEKQIGTMQA 1367

Human  1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429
            |:.|||||||...|.||.|||.::::|:|||.:|||.:|:.||:|||:||||||||||||:|||.
Zfish  1368 QLVDMKKKMEQESGSLECAEESRKRVQRDLEAVSQRLDERNAAFDKLDKTKTRLQQELDDMLVDQ 1432

Human  1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494
            ||.||...|||||||||||:|||||:|||:|||||||||||||||||:.|:|||.||...:.|.|
Zfish  1433 DHLRQIVSNLEKKQKKFDQMLAEEKSISARYAEERDRAEAEAREKETRMLALARELETLTDMKEE 1497

Human  1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
            |:|.||..|.|||||:|||||||||||:|||||||:|||:|||||||||||||||||||||||||
Zfish  1498 LDRTNKLLRAEMEDLVSSKDDVGKSVHDLEKSKRAMEQQLEEMKTQLEELEDELQATEDAKLRLE 1562

Human  1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
            ||:||||||:|||||||||..||||:||::||||||.|||||||||::|:|||||:|:|||:|||
Zfish  1563 VNMQAMKAQYERDLQGRDELGEEKKRQLLKQVREMEMELEDERKQRTLAMAARKKMELDLKELEA 1627

Human  1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689
            .||.||||||||:|||:|:||||||.:|||:|||.||||||||:||||||:|||||||||:||||
Zfish  1628 AIDQANKNRDEALKQLKKVQAQMKDLLRELEDTRLSREEILAQSKENEKKVKSMEAEMIQMQEEL 1692

Human  1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKK 1754
            |||||||||||||||||.|||.|.:.||||..||:||||||||||||||||||.||||:|||||:
Zfish  1693 AAAERAKRQAQQERDELQDEINNQAAKGALGSEERRRLEARIAQLEEELEEEQNNTELVNDRLKR 1757

Human  1755 ANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
            |.||.||:|.:|..|||.:|:.|.||.|.||||||||:||.|:||||||||||:|.||||||.||
Zfish  1758 ALLQTDQMNVELTAERSTSQRLEGARSQQERQNKELKLKLTELEGTVKSKYKATIAALEAKIGQL 1822

Human  1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884
            |||||.||:|||.|.|.|||||||||:|:|||||||||.||||||:||.::|:||||||||||||
Zfish  1823 EEQLDVETRERQQASKLVRRTEKKLKEVILQVDDERRNTEQYKDQSDKLNSRMKQLKRQLEEAEE 1887

Human  1885 EAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDG 1949
            |||||||:|||||||||||||:||||||||:|||:|||||||||.:.|.::|.|.  .|||:.:.
Zfish  1888 EAQRANANRRKLQRELEDATESADAMNREVNSLKSKLRRGDLPFTMRRIVSRSGI--ESDEDPEA 1950

Human  1950 KADGAEAKP 1958
            |::..|.||
Zfish  1951 KSETPEPKP 1959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		746/837 (89%)
		Myosin_N	27..72	CDD:460670	29/44 (66%)
		Motor_domain	95..764	CDD:473979	609/675 (90%)
		Actin-binding	654..676		20/21 (95%)
		Myosin_tail_1	841..1921	CDD:460256	833/1079 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		20/21 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		13/18 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960		58/82 (71%)
myh9b	NP_001427874.1	None