Protein Alignment MYH9 and Mhcl

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Alignment Length: 2068
• Identity: 530/2068 - (25%)
• Similarity: 878/2068 - (42%)
• Gaps: 588/2068 - (28%)

Human    24 ADWAAKKLVWVPSDKSGFEPA-------SLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFS 81
            ||.:..:.||: ..:.||..|       |.::|..:.:: .|:.||:::.|::||::|.|.|...
  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSL-RLLHNGEQLTVDEDDVEKQNSPALD 561

Human    82 KVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEM 146
            .|||:.||..||||||||.|::||.|.||:|.:|...:|:||...|.:|||::|.|::|.|..:|
  Fly   562 LVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDM 626

Human   147 PPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQL 211
            |||:|::..|||||:::.|.|||::..|.||:||:.:.|..:.|||..|.::.:          .
  Fly   627 PPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNN----------F 681

Human   212 LQAN------PILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKE 270
            :.|.      .|||||||.||..|.|::|..:.:.::||..|.|..|:::..|.|:.||.|:...
  Fly   682 INAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGH 746

Human   271 ERTFHIFYYLLSGAGEHLKTDLLLE---PYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIP 332
            |.:|||...||:||...|:.:|.||   ..:.:.|:|.........:..:.|..|::|...:.|.
  Fly   747 EHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNID 811

Human   333 EEEQMGLLRVISGVLQLG--NIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTR---GILTP 392
            .:...|:..:::.:..||  .:......:|.:....:.|||:|.|.|||:|:.|.:.   |:..|
  Fly   812 AKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQP 876

Human   393 RIKVGRDYVQKAQTK----EQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDI 453
            ....|.....|:.|.    |.|...:|||....|......:|..||:.:..:....|| |.::|.
  Fly   877 NAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLIDT 940

Human   454 AGFE------------IFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGL 506
            .||:            :.||..      ||..|:||.||:||..:..::.|.:|     .::..:
  Fly   941 PGFQNPASCGQQVGATLADLRH------NYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEM 994

Human   507 DLQ------PCIDLIEKPAGPP-----------------GILALLDEECWFPKATDKSFVEKVMQ 548
            ||.      |.|.||:|  .|.                 |:|.|||||..:|.:.|.:|:|::..
  Fly   995 DLASECHPGPLISLIDK--APQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFS 1057

Human   549 EQGT---HPKFQK---PKQLKDKADFCIIHYAG--KVDYKADEWLMKNMD-PLNDNIATLLHQSS 604
            ..|.   |...:|   |:|      |.:.|..|  .|.|..|.|:..:.: |...|..:||..||
  Fly  1058 HYGDREHHSLLRKCAGPRQ------FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSS 1116

Human   605 DK-----FVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVG--------QLYKEQLAK 656
            .:     ::..|.:....::.....||:..|.......:.:..|.|.|        |: |..:..
  Fly  1117 REEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQV-KFTVDG 1180

Human   657 LMATLRNTNPNFVRCIIPNHEKKAGK-----------------------LDPHLVLDQLRCNGVL 698
            ::.|||.|..:||.|.:..|  .|||                       ::..|:..|||.:.||
  Fly  1181 IIDTLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVL 1243

Human   699 EGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKAL-ELDSNLYRIGQSKVF 762
            |..|:.|.|||..|...||.:|:.:|..:     ....|...|..|.|: |||...||||.|::.
  Fly  1244 EAARLHRLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILAVNELDVASYRIGPSQIL 1303

Human   763 FRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQW 827
            ||:|||:.||.:||:.::|.||..||.||||||||..::|:.|..|::.:|||..|:|.:|:|.|
  Fly  1304 FRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPW 1368

Human   828 WRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
            |||..:|.|||.|.|.||::....|||:.:|.|       |.::|..:|::.||..:|:.:|
  Fly  1369 WRLLVRVTPLLNVHRTEEQLKTANEELLMLRAK-------LEKIECDRSEVKAENQKLEAKL--- 1423

Human   893 TELCAE-AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956
            :||..: |||   |.||         |....|:|.|       .||:.|:::.:.:...:::..:
  Fly  1424 SELTVDLAEE---RSTA---------HIATERLEAE-------TAERLKLEKELGDQTNKVKNLQ 1469

Human   957 SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA---EFTTNL--TEEEEKSK 1016
            ...:||::|.:..::.|..:.|:: ..|:::.......||..:|:|   |||...  |:.|...:
  Fly  1470 ETTEKLEMELICAKSDLNGISEDE-DAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLE 1533

Human  1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
            .|..||...|..::|..|.:   .:|||.:.:.:||.:..:.:::|           |:|.|
  Fly  1534 QLVALKKHLEMKLSDAYEEV---VEQRQVVGQWKRKAQKMTNEMND-----------LRMLL--- 1581

Human  1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
                       ||:.|:.|:..||.|:.:::...||:.:..||.::.:..::|    :.|:|.|.
  Fly  1582 -----------EEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK----DVLQAEKF 1631

Human  1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211
            .||.||..|....|.   :|:::..|::.|||             .......|   |:..|.:|.
  Fly  1632 TLEQTLADTRLDLEF---KEEKLASLQRELEE-------------MTFGGGTE---EEFAQLRRS 1677

Human  1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT 1276
            |...|:..:..|.|..|:|.::::|.|                                     .
  Fly  1678 KNETERRAKEQEEELDEMAGQIQLLEQ-------------------------------------A 1705

Human  1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341
            ||::|:                              |.|.:::|.|::       .|..|
  Fly  1706 KLRLEM------------------------------TLETMRKEARRE-------SQQRD----- 1728

Human  1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406
                ||.||.:.|..|:|..|..|              |||..|.:..|      |.::||
  Fly  1729 ----EELEEVRGNGYKKIKALECQ--------------LETEHEERTLL------LREKHE---- 1765

Human  1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471
                       |::.|..:                                    |:|||.:.:|
  Fly  1766 -----------LERRLSSM------------------------------------EDRDRVDRDA 1783

Human  1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536
                          |||:.||                              |.:..|..:..:::
  Fly  1784 --------------EEALNQK------------------------------LRRDLRKYKALLKD 1804

Human  1537 MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601
            .:||||.|                         :.|..|         |.|:||:|.   :|||.
  Fly  1805 AQTQLERL-------------------------KADTPG---------KTLIRQLRN---QLEDA 1832

Human  1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666
            ...||:|:.||:..|.:|.:::|..|.:::.|::|.:   :..|..:|           |.|:.|
  Fly  1833 ESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEE---RANAAHRD-----------RAELQA 1883

Human  1667 QAKENEKKL----KSMEAEMIQLQEE---LAAAERAKRQAQQERDELADEIA---------NSSG 1715
            |.:|||::|    |...|.:.||..|   ::.||....:.:.||:.|.:::|         .:.|
  Fly  1884 QIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLG 1948

Human  1716 KGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
            ..::|:..| |||.|..:||..||.||..         :|.|:: |:|           :::.|.
  Fly  1949 DPSMAMMSK-RLELRTKELESRLELEQAT---------RARLEV-QVN-----------RHKEAL 1991

Human  1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
            ::|  ||:..:.|::||:                                  |...:::::|.|:
  Fly  1992 EKL--QNEVTQSKMREMQ----------------------------------AQDVIKKSQKSLR 2020

Human  1846 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE-AQRANASRRKLQR----------- 1898
            |:       |........:..::.||.|.|::::|:.|.| |...|..|..|||
  Fly  2021 DM-------REEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEE 2078

Human  1899 ---ELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARK-----GAGDGS 1943
               ||.::.|:..::. .:|.|:::||    |..|.|...:.     |.|.||
  Fly  2079 GEEELSESDESLSSVG-SISDLEDRLR----PVHVKRSSQQSLNGSIGGGGGS 2126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		286/919 (31%)
		Myosin_N	27..72	CDD:460670	12/51 (24%)
		Motor_domain	95..764	CDD:473979	222/767 (29%)
		Actin-binding	654..676		7/21 (33%)
		Myosin_tail_1	841..1921	CDD:460256	232/1116 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960		23/87 (26%)
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	490/1903 (26%)
		MYSc_Myo18	575..1305	CDD:276837	222/767 (29%)