DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH9 and Prm

DIOPT Version :9

Sequence 1:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens
Sequence 2:NP_523982.2 Gene:Prm / 39002 FlyBaseID:FBgn0003149 Length:879 Species:Drosophila melanogaster


Alignment Length:848 Identity:238/848 - (28%)
Similarity:415/848 - (48%) Gaps:54/848 - (6%)


- Green bases have known domain annotations that are detailed below.


Human  1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167
            |..:..||.:|..||:|||.||..|.:.|::|.||..::..:...||:.......|.|...||:.
  Fly    34 LSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDA 98

Human  1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
            |:..|:|.||:.....|.....:::||::.:.:..||:|...:.||..||.|...:.|..||.::
  Fly    99 ELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQ 163

Human  1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV--------------RTELADKVTKLQVELD 1283
            ::...:.|..||....|:|..:.||.||..|..|.              ..||...|..|:|:||
  Fly   164 IESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLD 228

Human  1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348
            .|      |.|||..:        |||:|.:..|::|:|::..|.:.|.|||.|.:|.|.|||||
  Fly   229 TV------SFSKSQVI--------SQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279

Human  1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGC-LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412
            .||:.:||:|:...:|.....:.|....|.. .|..||::||.|..:..|.:..|..:...:.||
  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344

Human  1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE-----EKTISAKYAEERDRAEAEAR 1472
            |.||||..|::.|::||:....|...|.|.....::...|     ::||......:||     .:
  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRD-----LK 404

Human  1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
            .|....:.....|::..:...:|.|.||:...::.:...:.:::.:.:||||...|.||.:.:|:
  Fly   405 NKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDEL 469

Human  1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE-LEDE 1601
            ....:|.|...:|.|....||..:....:...||.|..:||:.|..:||...::.::.|. :|.|
  Fly   470 TAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAE 534

Human  1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNR---DEAIK----QLRKLQAQMKDCMRELDDTRA 1659
            .:.::.....:|||::.:.:||..:|.|||..   .:.||    ||.:|||..:|..|:|..|  
  Fly   535 TRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQAT-- 597

Human  1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724
                 |.|....:::|..:..|:.:::..|.:|.||||..:.:.:|.|..|...:......:..|
  Fly   598 -----LDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIK 657

Human  1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE 1789
            .:||..::.:..:.||......:.::|.:|..:::..:...::.|:....|.|..::.||.:.|.
  Fly   658 SKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKN 722

Human  1790 LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
            |.::|:|:|....:..|..|:.|||:|..||.:|:.|.:......|.:|:.|:.:|:||:|.:::
  Fly   723 LSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEED 787

Human  1855 RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919
            ::|....:|..||::.::...:|||.|.|..:|:.....|:.|||||.|.:.||.....::.::.
  Fly   788 QKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRA 852

Human  1920 KLR 1922
            |.|
  Fly   853 KHR 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838
Myosin_N 29..68 CDD:367160
Motor_domain 95..764 CDD:354959
Actin-binding 654..676
Myosin_tail_1 841..1921 CDD:366712 236/845 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137 8/18 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960 17/46 (37%)
PrmNP_523982.2 Myosin_tail_1 <34..853 CDD:279860 236/844 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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