Protein Alignment MYH9 and Myo61F

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1008
• Identity: 323/1008 - (32%)
• Similarity: 515/1008 - (51%)
• Gaps: 146/1008 - (14%)

Human    93 NEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTA 157
            :|.:.:.|||:|:...|||||.|...:.:||||.||||:::.|:.|:.|..:||||||:|:||.|
  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNA 114

Human   158 YRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFG 222
            :||::::...|.:|.:||||:||||.:|||:|::|  |.|......:| ::.:||::||:|||||
  Fly   115 FRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA--ACSGNQTTVEG-VKDKLLKSNPVLEAFG 176

Human   223 NAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEH 287
            ||||.:|||||||||::.|.||..|..:|.||..|||||||.:.|...||.|||||.||:||.|.
  Fly   177 NAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEA 241

Human   288 LKTDLLLE-PYNKYRFLSNG-HVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLG 350
            |..:|.|| ..:.|.:|::| :.|:....|.|.|::..:|:.::...:|||..:..:::.:|.||
  Fly   242 LLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLG 306

Human   351 NIVFKKERNTDQASMPD--NTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFA 413
            |:.|.:.....:.:..|  .|||:    |||:|.::....:....|....|.|.....:|.|.:|
  Fly   307 NVGFTEVEGNAKVNSRDLVVTAAR----LLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYA 367

Human   414 IEALAKATYERMFRWLVLRINKALD--KTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKL 476
            .:|||||.|:|:|.|||.|:|.:|.  :|:....:.:|||||.|||||..|||||.|||:.||||
  Fly   368 RDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKL 432

Human   477 QQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFP-KATDK 540
            ||||.......||:||:||||||..::: .|.:...:|||:.  ..||:::|||||..| :.|||
  Fly   433 QQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEEK--HKGIISILDEECLRPGEPTDK 494

Human   541 SFVEKVMQEQGTH---------PKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNI 596
            :|:||:.|:...|         |...|...|:|  :|.::||||:|.|..:.:|.||.|.|..::
  Fly   495 TFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRD--EFRLVHYAGEVTYSVNGFLDKNNDLLFRDL 557

Human   597 ATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATL 661
            ...|.::.:..|...:.:.: :..|.:    .|||:               ..::..|..||..|
  Fly   558 KETLSKAGNGIVRNCFPEKE-LRSLKR----PETAI---------------TQFRASLNNLMDIL 602

Human   662 RNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTP 726
            ....|:::|||.||..:.|...:..|||.|::..|::|.:|:.|.||..|..::.|.:||:.|:.
  Fly   603 MCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSK 667

Human   727 NSIP--KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFR--------------------AGVLA 769
            ::.|  ||....|.....::|.|..|...||:|::|:|.|                    |.:.|
  Fly   668 STWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQA 732

Human   770 H----LEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKV-----LQRNCA------AY 819
            |    ::..:.||:...:|..|:.||..||::|..||::....::.     :.||.|      .:
  Fly   733 HWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEF 797

Human   820 LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEE----LVKVREKQLAAENRLTEMETLQSQLMA 880
            :......|.....|..|...:.:.........||    |.::....||...||
  Fly   798 IANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRL------------ 850

Human   881 EKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQ---------- 935
             ||..|::.|.|.::.||        ...|.:.......:....:|:....:|:|
  Fly   851 -KLTPQQKRQFELKVLAE--------KVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTF 906

Human   936 -AEKKKMQQNIQELEEQ-----------------LEEEESARQK--LQLEKVTTEAKLKKLEEEQ 980
             :|:.|.|....:.:..                 :.:.::.:||  |.|:|:  :..|....::.
  Fly   907 GSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI--DFTLTNHNDDL 969

Human   981 IILEDQNCKLAKEKK---LLEDRIAEFTTNLTE 1010
            :::... ..|.|:|.   |:..||.||:|.:.:
  Fly   970 MVIRIP-LDLKKDKGDLILIIPRIIEFSTYIID 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		287/797 (36%)
		Myosin_N	27..72	CDD:460670
		Motor_domain	95..764	CDD:473979	265/686 (39%)
		Actin-binding	654..676		9/21 (43%)
		Myosin_tail_1	841..1921	CDD:460256	36/207 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	265/686 (39%)
		Myosin_TH1	863..1049	CDD:461801	24/150 (16%)