Protein Alignment MYH9 and Mhc

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1939
• Identity: 795/1939 - (41%)
• Similarity: 1189/1939 - (61%)
• Gaps: 49/1939 - (2%)

Human    28 AKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCL 92
            :||..|:|.:|.|:....:|...|:...|.| :.|:...:.||.:|::||||:.|.|||:.||.|
  Fly    34 SKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYL 97

Human    93 NEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTA 157
            |:|||||||::|||:.|||||||||||.|||||..|:|:....:||:||:|:|:||||:||:|.|
  Fly    98 NDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGA 162

Human   158 YRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHK---SKKDQGELERQLLQANPILE 219
            |..|:.:..:||:|.||||||||||||||||.|.|.|.:|.|   :.|.:|.||.|::|.||:||
  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227

Human   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284
            ||||||||:|||||||||||||:|...|.:.||:||||||||:|.|.|...||::||||.::||:
  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292

Human   285 GEHLK-TDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQ 348
            ...:| ..||.:....|..:|.|.||:....|.:.|..|.:|..|:|..::|:..:.|:.:.|:.
  Fly   293 VPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMH 357

Human   349 LGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFA 413
            :|.:.||:....:||.........:||.|.|.:..:..:.:|.||||||.::|.:.:..:|...:
  Fly   358 MGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNS 422

Human   414 IEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQ 478
            |.||.|..::|:|:|||.:.|:.|| |:::...|||:|||||||||:.|.|||||||:|||||||
  Fly   423 IGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQ 486

Human   479 LFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFV 543
            .|||.||:|||||||||||||.|||||:|||.||||||||.   |||::|:||..||||||::|.
  Fly   487 FFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPM---GILSILEEESMFPKATDQTFS 548

Human   544 EKVMQEQ-GTHPKFQKPKQLK---DKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSS 604
            ||:.... |....|||||..|   ..|.|.|.||||.|.|....||.||.|||||.:.....:|.
  Fly   549 EKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQ 613

Human   605 DKFVSELWKDVDRIIGLDQVAGMS---ETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNP 666
            :|.:.|::.|         .||.|   |.|..|..| :.|.|.||...|||||..||.|||:|.|
  Fly   614 NKLLIEIFAD---------HAGQSGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQP 668

Human   667 NFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPK 731
            :||||||||..|:.|.:|.|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :
  Fly   669 HFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-Q 732

Human   732 GFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLAR 796
            |....|:|..::||.::|..:.||:|.:|||||||||..:||.||.::..::...||..||||:|
  Fly   733 GVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSR 797

Human   797 KAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQ 861
            |.|.|.|:|..|:||:|||...||:||.|.|::|:.||||||.|||.|:|:...||:..|..|..
  Fly   798 KGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELH 862

Human   862 LAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926
            .|......|:|.|.::|:|||..|.:.|..|.....:.:|..|:|||:|.:||....|::.|:.:
  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ 927

Human   927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991
            ||:....|..:|||..|.|..|::.:|:.|...||.:.:|.|.:.:::.|.:|....::...||.
  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLN 992

Human   992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
            ||||:..:...:....|...|:|...|.|:|.|.|..:.:||:.|.||:|.|.::||::||:|||
  Fly   993 KEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057

Human  1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121
            .....:.:|:|:....||:..:.:|::||.:..|::|:|........::|:||:::|.||:|::|
  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVE 1122

Human  1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
            :||.:|.|||||:.||..|||.|...||:...:|:||.||..|||.|::.|::.|||....||:.
  Fly  1123 AERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHEST 1187

Human  1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251
            :..:|:||:.||.|:|||::|..::||..||.|.....:..:|...|..:...|...|...|:::
  Fly  1188 LANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQ 1252

Human  1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316
            ..|.|:|.|.:|..|...:......||.:|..::...|.:::|:.|:|:|...:|.:||:||:.|
  Fly  1253 HTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRL 1317

Human  1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME-DSVGCL 1380
            ..||:|::.:|..|.:.:|.:.::.|||:|||.|.|.:|::|::..:|:....:.|.| |.|...
  Fly  1318 ADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARS 1382

Human  1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDK----LEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
            |..||.|||||..|    ...||.:.:.::    |||||.||..|::||.:::|.....|...||
  Fly  1383 EELEEAKRKLQARL----AEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEK 1443

Human  1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
            |||.||:::.|.|......|.|.|.::.|.|...|:...|..|.||..||...:.|.||....|:
  Fly  1444 KQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEV 1508

Human  1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
            :||:....:.|:::||:||:::.||.:.:|::..|||.|..|:..|:..||.::.|..::.:.:|
  Fly  1509 KDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR 1573

Human  1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
            .:|.::|:.|..:|...|.:..|:|.||.|.|.::.|:..:||||.|:.:||..:|.|||...||
  Fly  1574 RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEA 1638

Human  1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701
            .|.:::.|.|:||....|::.:.:|::...|...:|::..:::.|:.:.:..|..|:|.:|||:|
  Fly  1639 QKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ 1703

Human  1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQIN 1763
            |..:..:::...|.:.|.....||:||:.:..|..:|:|   |..|:|   ::.|||.:...::.
  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLA 1765

Human  1764 TDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828
            .:|..|:.|||..|..|:.||:|.|||:|:|.|.|.......|.:|..||.::.:||.:||.|.:
  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830

Human  1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASR 1893
            ....|.|.:|::|:::|::..|.:::|:|.|:.:|..||...::|..|||:|||||.|....|..
  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895

Human  1894 RKLQRELEDATETADAMNREVSSLKNKLR-----RGDLPFVVPRRMARKGAGDG 1942
            ||.|:|||:|.|.||...:.:|..:.|.|     ||..|  .||..:.:...||
  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASP--APRATSVRPQFDG 1947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		413/820 (50%)
		Myosin_N	27..72	CDD:460670	13/43 (30%)
		Motor_domain	95..764	CDD:473979	348/679 (51%)
		Actin-binding	654..676		15/21 (71%)
		Myosin_tail_1	841..1921	CDD:460256	370/1087 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		11/21 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960		29/71 (41%)
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	11/41 (27%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	348/679 (51%)
		Myosin_tail_1	842..1922	CDD:460256	370/1086 (34%)